Background: Prosthetic rehabilitation for children and juvenile patients with congenital or acquired craniofacial disorders is the area of activity of many clinicians and is a major diagnostic and therapeutic challenge for dentists. Methods: Studies were carried out on a group of 30 patients (10 female and 20 male) aged 2.5 to 30 years who were treated prosthetically due to congenital and acquired craniofacial disorders. The aim of this study was to assess the quality of life using the CPQ 11-14 (Child Perception Questionnaire 11-14), OQLQ (Orthognathic Quality of Life Questionnaire), and PIDAQ (Psychosocial Impact of Dental Aesthetics Questionnaire). Results: Before the prosthetic treatments, the mean values in the individual questionnaires were, respectively, CPQ 11-14—54 points; OQLQ—44.4 points; and PIDAQ—47.6 points. The following values were obtained after the treatments: CPQ 11-14—12.43 points; OQLQ—22.27 points; and PIDAQ—34.03 points. All obtained differences were statistically significant. Conclusions: The total numerical results obtained in all questionnaires decreased, which means that prosthetic rehabilitation had a positive impact on the assessment of the quality of life based on individual categories.