Third molars: To extract or not to extract?

Normando, David

doi:10.1590/2176-9451.20.4.017-018.edt

Cited by 37 publications

(39 citation statements)

References 9 publications

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“…Extracted teeth are merely disposed as medical waste. 70 It is thus under minimal ethical concerns to utilize these cells and future translational application with donor matching or autogenic usage can be supported through "dental cell banking" concept. 19 Our study highlighted the plasticity and differential capacity of PDL cells to generate CSKs.…”

Section: Discussionmentioning

confidence: 99%

Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy

Yam

Teo

Setiawan

et al. 2018

J Cellular Molecular Medi

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Corneal opacities are a leading cause of global blindness. They are conventionally treated by the transplantation of donor corneal tissue, which is, restricted by a worldwide donor material shortage and allograft rejection. Autologous adult stem cells with a potential to differentiate into corneal stromal keratocytes (CSKs) could offer a suitable choice of cells for regenerative cell therapy. Postnatal periodontal ligament (PDL) contains a population of adult stem cells, which has a similar embryological origin as CSK, that is cranial neural crest. We harvested PDL cells from young adult teeth extracted because of non‐functional or orthodontic reason and differentiated them towards CSK phenotype using a two‐step protocol with spheroid formation followed by growth factor and cytokine induction in a stromal environment (human amnion stroma and porcine corneal stroma). Our results showed that the PDL‐differentiated CSK‐like cells expressed CSK markers (CD34, ALDH3A1, keratocan, lumican, CHST6, B3GNT7 and Col8A2) and had minimal expression of genes related to fibrosis and other lineages (vasculogenesis, adipogenesis, myogenesis, epitheliogenesis, neurogenesis and hematogenesis). Introduction of PDL spheroids into the stroma of porcine corneas resulted in extensive migration of cells inside the host stroma after 14‐day organ culture. Their quiescent nature and uniform cell distribution resembled to that of mature CSKs inside the native stroma. Our results demonstrated the potential translation of PDL cells for regenerative corneal cell therapy for corneal opacities.

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Section: Discussionmentioning

confidence: 99%

Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy

Yam

Teo

Setiawan

et al. 2018

J Cellular Molecular Medi

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“…30 Despite the fact that the role of third molars has been the subject of research, clinical interest, and debate for years, there is still a lack of scientific evidence from high-quality clinical studies on this subject. 42 However, Normando et al 43 suggest that, in general, the best clinical conduct is not to proceed with the prophylactic extraction of third molars, except in situations where removal of a third molar is mandatory from the beginning of treatment.…”

Section: Discussionmentioning

confidence: 99%

Remoção profilática de terceiros molares assintomáticos não irrompidos: é justificável?

Pedrosa

Silva

Cordeiro

et al. 2017

Rev. Bras. Odontol.

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Objective: to review the literature currently available on the evidence that does or does not justify the prophylactic extraction of unerupted asymptomatic third molars. Material and Methods: the electronic databases PubMed, Capes Periodicals, Web of Science and Scopus were searched from November to December 2016 by two authors, simultaneously, using as search terms: Terceiro Molar/Molar, Third AND Extração Profilática/Prophylatic Removal OR Prophylatic Extraction. We included articles from original research and clinical trials published in English and Portuguese. No limits were applied to the date of publication. Review articles and clinical case reports were removed. Results: we identified 13 studies that addressed, at some aspect, the prophylactic removal of unerupted asymptomatic third molars. The results of this literature review which alluded to the potential for the formation of pathological alterations in asymptomatic third molars are conflicting; While some justifies the prophylactic procedure based on the possible formation of associated lesions, other scientific evidence does not support such practice. Conclusion: in view of the conflicting viewpoints found in the literature, the prophylactic removal of asymptomatic third molars requires case-by-case evaluation of each patient, and the decision-making process, regarding the retention versus the prophylactic removal of these teeth should be based on scientific evidence combined with the clinical experience of the professional.

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“…The prophylactic removal of third molars is considered hazardous (Friedman 2007) and it is difficult to support or refute this procedure unambiguously (Costa et al 2013;Normando 2015). The prediction of the biological condition of an erupted third molar with any degree of reliability is difficult to estimate.…”

Section: Introductionmentioning

confidence: 99%

“…Literature review reveals that third molar extraction, as a surgical interference, may result in complications. Complication rates related to third molar may vary between 2.6 and 30.9%, and depends on various factors, including age, gender, tooth position and impact level, the surgeon's experience, smoking, oral hygiene, surgical technique and a few others (Chiapasco et al 1993;Boloux et al 2007;Normando 2015;Deliverska and Petkova 2016). Schwartz-Arad et al (2017) revealed that overall prevalence of postsurgical complications was 17%.…”

Section: Introductionmentioning

confidence: 99%

The incidence and extraction causes of third molars among young adults in Poland

Tomaszewska

Sikora

2019

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Despite many years of observation, the issue of third molars is still open for discussion. Among human teeth, third molars vary the most in number and morphology, which results from genetic changes and environmental factors affecting the evolution of the human dentition. This research aims to study various aspects of third molars in the population of young Poles, such as the incidence, time of eruption and causes of extraction in men and women. The analyses consider the socio-economic status of the respondents, including the frequency of visits to the dentist. Eight hundred students, aged 19–25 (14.4% of men and 85.6% of women) of the universities located in Wroclaw, Poland, took part in an online questionnaire survey. The incidence of third molars was smaller in the women (32.4–34.9%) than in men (47.8–56.5%) (p<0.001). For both sexes, the most frequent causes of extraction were abnormal tooth position (29.6–54.5%) and orthodontic treatment (15.5–27.3%). Both incidence and causes of extraction were related for all the examined pairs of teeth (upper–lower teeth and right–left teeth). The men (17.94–18.49 year) and women (18.42–18.83 year) did not differ in the mean age of their third molars’ eruption. The men visited the dentist less often than the women did (p<0.001). The study presents original research and confronts it with published results. Despite the limitations of an online survey, the results can contribute to more advanced research conducted on a larger scale. In particular, more detailed research is recommended for the Polish population, for which such studies are scarce.

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Third molars: To extract or not to extract?

Cited by 37 publications

References 9 publications

Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy

Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy

Remoção profilática de terceiros molares assintomáticos não irrompidos: é justificável?

The incidence and extraction causes of third molars among young adults in Poland

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