Introduction: Chronic Renal Disease (CKD) is an insidious, asymptomatic, progressive and irreversible renal damage. Added to hemodialysis treatment triggers negative effects on the cardiorespiratory, musculoskeletal system and quality of life (QOL). Therefore, we sought to evaluate functionality, quality of life and respiratory muscle strength and peak expiratory flow in patients with chronic renal failure on hemodialysis. Materials and methods: A cross-sectional and descriptive study, with a convenience sample of 30 individuals. An individual identification form, the Kidney Disease and Quality-of-Life Short-Form (KDQOL- SF) quality of life assessment instrument and the Functional Independence Measure (FIM) instrument were used. Also, specific tests for evaluation of respiratory muscle strength (RMS) and peak expiratory flow (PEF). Results: A homogeneous sample characterized as old adults with low schooling, and mostly hypertensive and diabetic. Individuals with complete functional independence (FIM: 118.13±17.1). There was a great decline in respiratory muscle strength and peak expiratory flow, about 40-50% of predicted values. With significant impact on the situation of work and sexual function, 25±42.9 and 45.5±44.3, respectively. Positive values were obtained on social interaction and stimulation by the dialysis team. Conclusion: It was concluded that there are no impacts on its functionality. However, there is a significant decline in respiratory functional parameters, such as respiratory muscle strength and peak expiratory flow, as well as in the health-related quality of life of chronic renal patients undergoing hemodialysis treatment.