Probiotics in the treatment of chronic kidney disease: a systematic review

Fagundes, Raquel Aparecida Bandeira; Soder, Taís Fátima; Castro, Kamila; Benetti, Fábia; Mendes, Roberta Hack

doi:10.1590/2175-8239-jbn-3931

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…12 Also, a mixture of Bidobacterium and Lactobacillus species could alleviate chronic kidney failure by reducing the plasma levels of urea, indoxyl sulfate and p-cresol. 13 More relevant to this study, probiotics were found to inhibit the development of colon cancers through inducing apoptosis and modulating the cellular defensive mechanisms. 14 Prebiotics are bioactive substances, fermented by the normal gut microora to benecial products such as butyrate and propionate which inhibit colon cancer biomarkers.…”

Section: Introductionmentioning

confidence: 92%

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

et al. 2019

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Colon cancer is a complex disease that involves numerous genetic alterations that change the normal colonic mucosa into invasive adenocarcinoma. In the current study, the protective effects of inulin (prebiotic), Lactobacillus casei (L. casei, probiotic) and their combination (synbiotic) on 1,2dimethylhydrazine (DMH)-induced colon cancer in male Swiss mice were evaluated. Animals were divided into: Control group, DMH-treated group, DMH plus inulin, DMH plus L. casei and DMH plus inulin plus L. casei-treated groups. Fecal microbiome analysis, biochemical measurements, histopathological examination of the colon tissues, immunostaining and Western blotting analysis of bcatenin, GSK3b and JNK-1 were performed. The prebiotic-, probiotic-and synbiotic-treated groups showed decreased levels of carcinoembryonic antigen and a lower number of aberrant crypt foci compared to the DMH-treated group with the synbiotic group exhibiting a superior effect. Furthermore, all treatments showed a body weight-reducing effect. Administration of inulin, L. casei or their combination increased the expression level of phospho-JNK-1 while they decreased the expression level of b-catenin and phospho-GSK3b. Remarkably, L. casei treatment resulted in enrichment of certain beneficial bacterial genera i.e. Akkermansia and Turicibacter. Therefore, administration of L. casei and inulin as a synbiotic combination protects against colon cancer in mice.

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Section: Introductionmentioning

confidence: 92%

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

et al. 2019

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“…According to the currently available evidence in a meta-analysis, there is no conclusive rationale for recommending biotic supplements for improving outcomes in renal patients [ 162 ]. Recent studies showed promising effects of probiotics in renal function and reduced levels of urea, blood urea nitrogen, and indoxyl sulfate in CKD patients [ 163 ]. Immunological, biochemical, and hemodynamic mechanisms are involved in the pathogenesis of AKI.…”

Section: Nutrients and Bioactive Compoundsmentioning

confidence: 99%

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Askari

Sanadgol

Azarnezhad

et al. 2021

Heliyon

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Recently, the novel coronavirus disease 2019 , has attracted the attention of scientists where it has a high mortality rate among older adults and individuals suffering from chronic diseases, such as chronic kidney diseases (CKD). It is important to elucidate molecular mechanisms by which COVID-19 affects the kidneys and accordingly develop proper nutritional and pharmacological strategies. Although numerous studies have recently recommended several approaches for the management of COVID-19 in CKD, its impact on patients with renal diseases remains the biggest challenge worldwide. In this paper, we review the most recent evidence regarding causality, potential nutritional supplements, therapeutic options, and management of COVID-19 infection in vulnerable individuals and patients with CKD. To date, there is no effective treatment for COVID-19-induced kidney dysfunction, and current treatments are yet limited to anti-inflammatory (e.g. ibuprofen) and anti-viral medications (e.g. Remdesivir, and Chloroquine/Hydroxychloroquine) that may increase the chance of treatment. In conclusion, the knowledge about kidney damage in COVID-19 is very limited, and this review improves our ability to introduce novel approaches for future clinical trials for this contiguous disease.

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“…Chronic kidney disease (CKD) is a lethal global syndrome, also called “silent disease,” characterized by progressive reduction in renal functions, kidney infection commencement, and premature death. Incidence of diabetes mellitus, obesity, and hypertension largely contributed to the prevalence of CKD ( Fagundes et al, 2018 ). Wang et al (2015) reported prophylactic and therapeutic effects of Lactobacillus and Bifidobacterium spp.…”

Section: Health-boosting Spectrum Of Probioticsmentioning

confidence: 99%

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

2020

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Probiotics are considered as the twenty-first century panpharmacon due to their competent remedial power to cure from gastrointestinal dysbiosis, systematic metabolic diseases, and genetic impairments up to complicated neurodegenerative disorders. They paved the way for an innovative managing of various severe diseases through palatable food products. The probiotics’ role as a “bio-therapy” increased their significance in food and medicine due to many competitive advantages over traditional treatment therapies. Their prophylactic and therapeutic potential has been assessed through hundreds of preclinical and clinical studies. In addition, the food industry employs probiotics as functional and nutraceutical ingredients to enhance the added value of food product in terms of increased health benefits. However, regardless of promising health-boosting effects, the probiotics’ efficacy still needs an in-depth understanding of systematic mechanisms and factors supporting the healthy actions.

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Probiotics in the treatment of chronic kidney disease: a systematic review

Cited by 28 publications

References 27 publications

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

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