The furosemide stress test: Perspectives for acute kidney injury diagnosis

López-Hernández, Francisco J.

doi:10.1590/2175-8239-jbn-2021-e010

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Recently standardized to study tubular function integrity in humans [ 130 , 131 ], and more recently in rats [ 52 , 103 ], the FST consists of the measurement of the acute, timed diuretic and kaliuretic response to a single administration of furosemide. This response is dependent on intact secretion of furosemide to the lumen of the proximal tubule from peritubular capillaries, and the binding and inhibition of the NKCC transporter in the loop of Henle [ 132 ]. Tubular alterations causing impaired proximal secretion of furosemide or action at the loop of Henle result in reductions in the diuretic and kaliuretic response.…”

Section: Pre-emptive Assessment Of Risk: Perspectives Of a New Diagno...mentioning

confidence: 99%

Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives

Casanova

Sancho-Martínez

Vicente-Vicente

et al. 2022

JCM

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Diagnosis of cardiac surgery-associated acute kidney injury (CSA-AKI), a syndrome of sudden renal dysfunction occurring in the immediate post-operative period, is still sub-optimal. Standard CSA-AKI diagnosis is performed according to the international criteria for AKI diagnosis, afflicted with insufficient sensitivity, specificity, and prognostic capacity. In this article, we describe the limitations of current diagnostic procedures and of the so-called injury biomarkers and analyze new strategies under development for a conceptually enhanced diagnosis of CSA-AKI. Specifically, early pathophysiological diagnosis and patient stratification based on the underlying mechanisms of disease are presented as ongoing developments. This new approach should be underpinned by process-specific biomarkers including, but not limited to, glomerular filtration rate (GFR) to other functions of renal excretion causing GFR-independent hydro-electrolytic and acid-based disorders. In addition, biomarker-based strategies for the assessment of AKI evolution and prognosis are also discussed. Finally, special focus is devoted to the novel concept of pre-emptive diagnosis of acquired risk of AKI, a premorbid condition of renal frailty providing interesting prophylactic opportunities to prevent disease through diagnosis-guided personalized patient handling. Indeed, a new strategy of risk assessment complementing the traditional scores based on the computing of risk factors is advanced. The new strategy pinpoints the assessment of the status of the primary mechanisms of renal function regulation on which the impact of risk factors converges, namely renal hemodynamics and tubular competence, to generate a composite and personalized estimation of individual risk.

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Section: Pre-emptive Assessment Of Risk: Perspectives Of a New Diagno...mentioning

confidence: 99%

Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives

Casanova

Sancho-Martínez

Vicente-Vicente

et al. 2022

JCM

Self Cite

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Pathophysiology of Acute Kidney Frailty

Sancho-Martínez,

López-Hernández

2023

Physiology

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Acute kidney frailty is a premorbid condition of diminished renal functional reserve that predisposes to acute kidney injury; this condition results from subclinical wear or distortion of renal homeostatic responses that protect the renal excretory function. Knowledge of its pathophysiological basis is critical for the development of diagnostic and therapeutic strategies that allow for prophylactic intervention and disease prevention.

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Covid-19-induced acute kidney injury in critical patients: what does the literature say / Lesão aguda induzida pela covid-19 em pacientes críticos: o que diz a literatura?

Costa

Muniz

Ribeiro

2023

RPCF

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Objetivo: identificar por meio da literatura a relação entre lesão renal aguda (LRA) e COVID-19, no paciente crítico. Método: revisão integrativa da literatura, com seleção dos artigos publicados entre 2020 e 2021 nas bases de dados da Biblioteca Virtual da Saúde: LILACS, SCIELO, PUBMED. Por meio dos descritores “Lesão Renal Aguda” AND “Coronavírus-19” AND “Unidade de Terapia Intensiva”. Resultados: o estudo foi composto por um recorte de 12 publicações. Os estudos em geral apontam que a LRA no contexto da COVID-19, é de causa multifatorial, entretanto não há consenso sobre essa afirmativa, uma vez que alguns estudos apontam que a COVID-19 contribui diretamente para novos casos de LRA em pacientes críticos devido à cascata de citocinas presente na patologia, o que não foi confirmado por todos os estudos. Conclusão: esta revisão evidenciou que a LRA é uma complicação presente em pacientes críticos com Covid-19. Os estudos encontrados demonstram que o assunto ainda precisa melhor explorado para que a relação entre o COVID-19 e a LRA seja definitivamente esclarecida.

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The furosemide stress test: Perspectives for acute kidney injury diagnosis

Cited by 3 publications

References 17 publications

Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives

Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives

Pathophysiology of Acute Kidney Frailty

Covid-19-induced acute kidney injury in critical patients: what does the literature say / Lesão aguda induzida pela covid-19 em pacientes críticos: o que diz a literatura?

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