The kidney: function, cells and biomarkers

Younes-Ibrahim, Maurício

doi:10.1590/2175-8239-jbn-2020-0215

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Nos últimos anos, tem sido intensa a busca por marcadores mais específicos para o diagnóstico de lesão celular aguda no tecido renal (11). Surgiram vários candidatos a novos biomarcadores na IRA, originados em diferentes partes do néfron (12).…”

Section: Novos Biomarcadores Na Iraunclassified

Injúria Renal Aguda

Younes-Ibrahim¹

2022

Anais da ANM

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Esta apresentação foi preparada para alunos de graduação, médicos recém-formados e iniciantes em atividades nas salas de emergência, contendo tópicos elementares da nefrologia, como parte do Curso de Emergências Clínicas da ANM em 2021. Por questões conceituais, historicamente, o termo clássico “insuficiência renal aguda” foi substituído por “injúria renal aguda” (IRA) e as justificativas para esta mudança serão tratadas mais adiante no texto.

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Section: Novos Biomarcadores Na Iraunclassified

Injúria Renal Aguda

Younes-Ibrahim¹

2022

Anais da ANM

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“…Currently, many markers of kidney function are known. Among the biomarkers of kidney function, we can distinguish serum creatinine, urine output, and urine microscopy [13,14]. However, creatinine, as a marker for glomerular filtration rate (EGFR), is not sensitive, as it does not increase until a significant drop in EGFR or substantial parenchymal injury has occurred, nor does it represent any specific process that leads to the EGFR decline [15,16].…”

Section: Introductionmentioning

confidence: 99%

Association between Leukocyte Cell-Derived Chemotaxin 2 and Metabolic and Renal Diseases in a Geriatric Population: A Pilot Study

Kuzan,

Maksymowicz,

Królewicz

et al. 2023

JCM

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LECT2 is not a routine diagnostic marker for any disease, but it has been associated with many pathologies, including systemic amyloidosis, rheumatoid arthritis, diabetes, atherosclerosis, and metabolic syndrome. With human aortic sections (n = 22) and sera from geriatric subjects (n = 79), we analyzed the relationships that could be observed between this protein and other parameters related to metabolic diseases. As a result, we observed a relatively high (r~0.8, p < 0.05) positive correlation between SRA and LECT2 and a negative correlation between EGFR and LECT2 (r~−0.4, p < 0.05). We observed LECT2 expression in macrophages, myocytes, and other aortic cells, with a tendency to be overexpressed in developed atherosclerotic plaques. We conclude that LECT2 exerts its chemotactic effects not only as a protein synthesized in the liver and secreted and circulating in the blood but also as a locally expressed protein within atherosclerotic plaque development. The LECT2-EGFR correlation suggests an association of this protein with loss of normal renal function. This fact can be associated with LECT2 amyloidosis, although it should be verified whether in the geriatric population there is indeed a widespread accumulation of LECT2 with the progression of aging or whether it is rather a marker of general deterioration of renal function.

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The kidney: function, cells and biomarkers

Cited by 2 publications

References 8 publications

Injúria Renal Aguda

Injúria Renal Aguda

Association between Leukocyte Cell-Derived Chemotaxin 2 and Metabolic and Renal Diseases in a Geriatric Population: A Pilot Study

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