Non-lupus full-house nephropathy: a case series

Silva, Márcia de Oliveira; Oliveira, Patrick Vanttinny Vieira de; Vale, Pedro Henrique Cavalcante; Cunha, Rinadja; Lages, Joyce Santos; Brito, Dyego José de Araújo; Filho, Natalino Salgado; Guedes, Felipe Leite; Silva, Gyl Eanes Barros; Santos, Ricardo Ferreira

doi:10.1590/2175-8239-jbn-2019-0242

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…3 However, it has been reported that the prevalence of no-lupus full-house nephropathy was 20%-30%. [12][13][14][15] Pathologies of full-house nephropathy should also be considered in the differential diagnosis of SLE, including primary glomerular diseases (membranous nephropathy, C1q nephropathy, IgA nephropathy), infections (endocarditis, HIV, HBV, HCV, BK, and CMV virus), diabetes mellitus, and liver diseases. [12][13][14] This patient had none any evidence of these disease.…”

Section: Case Reportmentioning

confidence: 99%

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

Li,

Bian

2023

Clinical Case Reports

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Key Clinical MessageSystemic lupus erythematosus is difficult to diagnose in patients who are antinuclear antibody (ANA) negative and lack typical clinical manifestations. For such patient who presented ANA‐negative severe lupus‐like manifestations, the diagnosis and treatment are a huge challenge. Histological findings may provide clues to diagnosis.AbstractSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by formation of autoantibodies to nuclear and cytoplasmic antigens. It was reported that a small subset of patients had typical clinical features of SLE with consistently negative antinuclear antibody (ANA), but such disease is usually mild and rarely involves multisystem. At present, there are no reports about severe lupus with ANA continued negative. Our report describes a 34‐year‐old Chinese woman who presented renal failure, multiple serous cavity effusion, and epilepsy, without malar rash, photosensitivity, lymphopenia, and arthritis. Further renal biopsy pathology revealed lupus‐like nephritis. Autoantibodies, including ANA, antibodies against Smith and against double stranded DNA, were negative. Such a ANA negative and lack of typical clinical symptoms of SLE patient, but with severe lupus‐like manifestations, whether it was lupus or not is worth discussing.

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Section: Case Reportmentioning

confidence: 99%

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

Li,

Bian

2023

Clinical Case Reports

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Immunosuppressants

2022

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Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition

et al. 2022

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Background Bartonella endocarditis is often a diagnostic challenge due to its variable clinical manifestations, especially when it is first presented with involvement of organs other than skin and lymph nodes, such as the kidney. Case presentation This was a 13-year-old girl presenting with fever, chest and abdominal pain, acute kidney injury, nephrotic-range proteinuria and low complement levels. Her kidney biopsy showed diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition shown by immunofluorescence, which was initially considered consistent with systemic lupus erythematous-associated glomerulonephritis (lupus nephritis). After extensive workup, Bartonella endocarditis was diagnosed. Antibiotic treatment and valvular replacement surgery were undertaken with subsequent return of kidney function to normal range. Conclusion This case demonstrates the importance of considering the full clinical picture when interpreting clinical, laboratory and biopsy findings, because the treatment strategy for infective endocarditis versus lupus nephritis is drastically different.

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Non-lupus full-house nephropathy: a case series

Cited by 3 publications

References 15 publications

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

Immunosuppressants

Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition

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