Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?

Moreira, Carla Leal; Cunha, Liliana; Correia, Sofia; Silva, Filipa; Castro, Ana; Tavares, Joana; Carvalho, Maria João; Oliveira, José Carlos; Santos, Olívia; Cabrita, António; Rodrigues, Anabela

doi:10.1590/2175-8239-jbn-2019-0007

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…Cystatin C plays role in many biological processes, GFR is based on the same logic similar to that for blood urea nitrogen and creatinine. But because it is neither reabsorbed nor secreted by renal tubules, it is suggested to be closer to the ideal endogenous marker (7) .…”

Section: Discussionmentioning

confidence: 99%

Measurement of Some non-routine Markers in Patients with Chronic Kidney Disease

Laibi¹,

Jawad²

2021

Indian Journal of Forensic Medicine & Toxicology

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Chronic kidney disease has an indirect effect on global disorder and death by raising the risks of morbidity and mortality . This study included (60) patient diagnosed chronic renal failure; it also included (25) healthy subjects as control . In study population age ranged from (14-65 years) old who visited Al-Basrah Teaching Hospital in Basrah throughout the period from October 2020 to February 2021. Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure human serum soluble alpha klotho proteins , irisin and cystatin C . The results showed that there is a high significant difference (P value < 0.01) in the levels between CKD patients and control for the following : Soluble-a-klotho protein; Irisin (ng/ml) ; Cystatin-C (ng/ml). There was also a high significant decrease in the levels of irisin (ng/ml)among different stages of chronic kidney . The same table revealed a high significant increase (P value <0.01) in the levels of Cystatin-C (ng/ ml) and Soluble-a-klotho protein (ng/ml) among different stages of chronic kidney and respectively) . The study concluded that there is a remarkable decrease in the level of serum soluble alpha klotho proteins and irisin and increase in serum cystatin C in patients with chronic kidney disease ; and these differences are positively correlated with the glomerular filtration rate .

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Section: Discussionmentioning

confidence: 99%

Measurement of Some non-routine Markers in Patients with Chronic Kidney Disease

Laibi¹,

Jawad²

2021

Indian Journal of Forensic Medicine & Toxicology

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“…Loss of RRF was defined as an average clearance of urea and creatinine (CrUCL) lower than 2 ml/min/1.73 m 2 . [ 20 ] Loss of diuresis was defined as a urinary output of less than 400 ml per day, as described elsewhere [ 21 ]. Lastly, follow-up data included transport status 12 months after sampling measured by D/P for creatinine using the modified PET.…”

Section: Methodsmentioning

confidence: 99%

“…According to their 1-year transport status, sCD59 PDF levels were significantly higher in the high-average/high group (Fig. 3a, 46 [43-50] versus 26 [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]; P < 0.001). PDF sCD59 levels correlated with D/P after 1 year (Fig.…”

Section: Scd59 Predicts Pmf and Loss Of Rrf During Follow-upmentioning

confidence: 99%

Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function

et al. 2020

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Introduction Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its assessment, however, is limited in clinical practice due to the lack of easy access to the peritoneal membrane. Recently, a soluble form of the complement regulatory protein CD59 (sCD59) has been described. We therefore aimed to investigate the role of sCD59 in PD. Methods Plasma sCD59 was measured in 48 PD patients, 41 hemodialysis patients, 15 non-dialysis patients with chronic kidney disease and 14 healthy controls by ELISA (Hycult; HK374-02). Additionally, sCD59 and sC5b-9 were assessed in the peritoneal dialysate. Results sCD59 and sC5b-9 were detectable in the peritoneal dialysate of all patients, and marginally correlated (r = 0.27, P = 0.06). Plasma sCD59 levels were significantly higher in PD patients than in patients with chronic kidney disease and healthy controls, but did not differ from hemodialysis patients. During follow-up, 19% of PD patients developed peritoneal membrane failure and 27% of PD patients developed loss of residual renal function. In adjusted models, increased sCD59 levels in the dialysate (HR 3.44, 95% CI 1.04–11.40, P = 0.04) and in plasma (HR 1.08, 95% CI 1.01–1.17, P = 0.04) were independently associated with the occurrence of peritoneal membrane failure. Higher plasma levels of sCD59 were also associated with loss of residual renal function (HR 1.10, 95% CI 1.04–1.17, P < 0.001). Conclusions Our study suggests that sCD59 has potential as a biomarker to predict peritoneal membrane function and loss of residual renal function in PD, thereby offering a tool to improve patient management. Graphic abstract

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“…Contrastingly, a study done by Moreira et al further investigated how CysC is associated with CVD in patients on peritoneal dialysis [28]. The study focused on 52 stable peritoneal dialysis patients with adequate residual renal function (RRF); minimal RRF was described as > 2mL/min/1.73m 2 .…”

Section: Other Roles Of Cystatin Cmentioning

confidence: 99%

Cystatin C as A Prognostic Biomarker to Monitor Renal Function in Liver Cirrhosis: A Narrative Review

Ismail,

Ali

et al. 2023

International Journal of Scientific Advances

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Cystatin C (CysC) is a serum protein that has been accepted as an early and precise biomarker of chronic kidney disease (CKD) that is especially useful in patients for whom creatinine (Cr) is deemed an inadequate marker. Estimates of the glomerular filtration rate using serum CysC are proposed as good predictors of renal function. This narrative review was done to review the use of CysC and its estimated glomerular filtration rate as a prognostic marker for renal function in patients diagnosed with liver cirrhosis. A review of the literature was conducted using databases including PubMed, Google Scholar, Science Direct, and Medline. Twenty-eight studies were included in the review. The discovery of CysC has revolutionized early detection and potential reversal of kidney damage in cirrhotic patients, improving outcomes significantly. Unlike Cr-based equations, CysC offers a promising alternative for detecting decreased glomerular filtration rate (GFR) and shows significant associations with various factors, supporting its reliability as a biomarker. Its role extends beyond renal function, showing potential in cardiovascular disease (CVD), mortality, kidney transplant function, and transplant failure.

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Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?

Cited by 4 publications

References 23 publications

Measurement of Some non-routine Markers in Patients with Chronic Kidney Disease

Measurement of Some non-routine Markers in Patients with Chronic Kidney Disease

Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function

Cystatin C as A Prognostic Biomarker to Monitor Renal Function in Liver Cirrhosis: A Narrative Review

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