Chronic kidney disease patients who smoke have higher serum phosphorus

Santos, Geuza Dutra dos; Elias, Rosilene Motta; Dalboni, Maria Aparecida; Silva, Giovânio Vieira da; Moysés, Rosa Maria Affonso

doi:10.1590/2175-8239-jbn-2018-0156

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…An abnormal increase in IP content in serum is an essential indicator for detecting chronic kidney disease 27 , 28 . This study found that after injection of different doses of curcumin, the content of Ur, UA, and IP in the serum of the curcumin treatments decreased significantly, indicating that the curcumin drug had played a role in protecting renal function.…”

Section: Discussionmentioning

confidence: 99%

Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats

et al. 2023

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Purpose: To explore the role and mechanism of curcumin (Cur) in reducing oxidative stress damage in rats with nephrolithiasis induced by ethylene glycol (EG). Methods: Thirty male rats were divided into normal control, model, positive (10% potassium citrate), Cur-10 (10 mg/kg curcumin) and Cur-20 (20 mg/kg curcumin) groups. Results: The results of kidney tissue section stained by hematoxylin-eosin and von Kossa showed that curcumin treatment can inhibit the formation of kidney stones. The biochemical test results showed that the urea (Ur), creatinine (Cr), uric acid (UA), inorganic phosphorus and Ca 2+ concentrations in urine decreased after being treated with curcumin. There were significant differences between different doses of curcumin (P < 0.05). Compared with the Cur-10 group, Cur-20 had a more significant inhibitory effect on malondialdehyde (MDA) (P < 0.05). In addition, reverse transcription polymerase chain reaction (PCR) detection and immunohistochemical results indicated that the osteopontin (OPN) in the kidney was significantly reduced after curcumin treatment. Conclusions: Curcumin could reduce the oxidative stress damage caused by EG-induced kidney stones.

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Section: Discussionmentioning

confidence: 99%

Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats

et al. 2023

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“…Diammonium phosphate is added to tobacco products to improve flavor, 78 and tobacco plants are often grown with triple superphosphate fertilizer 79 . Coincidently, among patients with CKD, smokers had higher serum phosphate levels compared to non‐smokers, even after researchers adjusted for renal function, 80 inferring that tobacco smoking might increase phosphate exposure through inhalation. Hypothetically, as a potential risk factor for SERCA2a dysfunction, excessive inhalation of Pi from tobacco smoke could explain why a meta‐analysis found a threefold increased risk of sudden cardiac death in current smokers compared to never smokers 81 .…”

Section: Other Areas For Future Researchmentioning

confidence: 99%

Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest

Brown

2023

The FASEB Journal

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Almost half of the people who die from sudden cardiac arrest have no detectable heart disease. Among children and young adults, the cause of approximately one-third of deaths from sudden cardiac arrest remains unexplained after thorough examination. Sudden cardiac arrest and related sudden cardiac death are attributed to dysfunctional cardiac ion-channels. The present perspective paper proposes a pathophysiological mechanism by which phosphate toxicity from cellular accumulation of dysregulated inorganic phosphate interferes with normal calcium handling in the heart, leading to sudden cardiac arrest. During cardiac muscle relaxation following contraction, SERCA2a pumps actively transport calcium ions into the sarcoplasmic reticulum, powered by ATP hydrolysis that produces ADP and inorganic phosphate end products. Reviewed evidence supports the proposal that end-product inhibition of SERCA2a occurs as increasing levels of inorganic phosphate drive up phosphate toxicity and bring cardiac function to a sudden and unexpected halt. The paper concludes that end-product inhibition from ATP hydrolysis is the mediating factor in the association of sudden cardiac arrest with phosphate toxicity. However, current technology lacks the ability to directly measure this pathophysiological mechanism in active myocardium, and further research is needed to confirm phosphate toxicity as a risk factor in individuals with sudden cardiac arrest. Moreover, phosphate toxicity may be reduced through modification of dietary phosphate intake, with potential for employing low-phosphate dietary interventions to reduce the risk of sudden cardiac arrest.

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“…Smoking negatively affects bone health by inducing more bone resorption and mineralization defect [ 8 ]. In addition, predialysis CKD patients, who are smokers have higher phosphate levels independent of FGF23 and renal function [ 9 ]. Concerning the acute detrimental effects of excess alcohol consumption, Asadipooya and Graves reported that excess alcohol consumption caused transient osteoporosis.…”

Section: Nonpharmacological Approachmentioning

confidence: 99%

Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II

et al. 2021

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Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality. The pharmacological and nonpharmacological interventions detailed, herein, are potential approaches to improve bone health in CKD patients. Various medications build up bone mass but also affect bone tissue quality. Antiresorptive therapies strikingly reduce bone turnover; however, they can impair bone mineralization and negatively affect the ability to repair bone microdamage and cause an increase in bone brittleness. On the other hand, some osteoporosis therapies may cause a redistribution of bone structure that may improve bone strength without noticeable effect on BMD. This may explain why some drugs can affect fracture risk disproportionately to changes in BMD. Summary: An accurate detection of the underlying bone abnormalities in CKD patients, including bone quantity and quality abnormalities, helps in institution of appropriate management strategies. Here in this part II, we are focusing on advancements in bone therapeutics that are anticipated to improve bone health and decrease mortality in CKD patients. Key Messages: Therapeutic interventions to improve bone health can potentially advance life span. Emphasis should be given to the impact of various therapeutic interventions on bone quality.

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Chronic kidney disease patients who smoke have higher serum phosphorus

Cited by 6 publications

References 17 publications

Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats

Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats

Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest

Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II

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