Reserva Ecológica do IBGE (Brasília - DF): Flacourtiaceae

Marquete, Ronaldo

doi:10.1590/2175-78602001528001

Cited by 8 publications

(2 citation statements)

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“…Casearia sylvestris Swartz (Salicaceae), known as "guaçatonga" or "erva-de-bugre", is a plant species distributed throughout South America that occurs in 22 states of Brazil, especially within the Atlantic and Amazon forests and the Cerrado biomes (Marquete 2001, Sleumer 1980. The plant has been widely used in traditional medicine for the treatment of snake bites and in wound healing, and also as an antiulcer and topical antiseptic (Hoehne 1939, Lorenzi andMatos 2002 antiulcerogenic, anti-inflammatory, antivenom, and cytotoxic (tumor cell lines) activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

Claudino

Sacramento

Koch

et al. 2013

An. Acad. Bras. Ciênc.

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Casearia sylvestris Swartz (Salicaceae) has been used in traditional medicine and its leaf extracts have been exhibited important pharmacological activities. The species presents morphological, chemical and genetic variation. Two varieties are considered due external morphological differences: C. sylvestris var. sylvestris and var. lingua. There are difficulties in definition of these varieties. The objective of this work is to evaluate chemical and morpho-anatomical differences between C. sylvestris varieties that can be applied in their distinction for pharmaceutical or botanical purposes. Transverse and paradermic sections of leaves were prepared for morphoanatomical, histochemical and quantitative microscopy (stomatal and palisade index) analyses. Diterpene profiles of the specimens were obtained by HPLC-DAD and TLC. Morpho-anatomical analyses demonstrated significant differences between the varieties only in paradermic sections: var. sylvestris -polygonal epidermic cell walls and hypostomatic; var. lingua -rounded epidermic cell walls and amphistomatic. No differences were observed for stomatal index; palisade index was found 2.8 for var. lingua and 3.9 for var. sylvestris. Chromatographic analyses confirmed previous results demonstrating that diterpene profile in varieties differs, with predominance of these metabolites in var. sylvestris. In conclusion, this work indicates that chromatographic analysis besides morphoanatomical analysis can be applied in distinction of C. sylvestris varieties.

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Section: Introductionmentioning

confidence: 99%

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

Claudino

Sacramento

Koch

et al. 2013

An. Acad. Bras. Ciênc.

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“…

Casearia sylvestris Swartz, Salicaceae, is a native plant from Brazilian flora known as guaçatonga [1]. Herbal preparations of C. sylvestris leaves have been used as antiseptic, anti-inflammatory, antiulcer, febrifuge, depurative, antidiarrheal, and antivenom drugs in Brazilian folk medicine.

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confidence: 99%

Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F

et al. 2023

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Oral preparations of Casearia sylvestris (guacatonga) are used as antacid, analgesic, anti-inflammatory and antiulcerogenic activities. The clerodane diterpenes casearin B (cas B) and caseargrewiin F (casg F) are major active compounds in vitro and in vivo. The oral bioavailability and metabolism of cas B and casg F were not previously investigated. We aimed to assess the stability of cas B and casg F in physiological conditions and their metabolism in human liver microsomes (HLM). The compounds were identified by UHPLC-QTOF-MS/MS and quantified by validated LC-MS methods. The stability of cas B and casg F in physiological conditions was assessed in vitro. Both diterpenes showed a fast degradation (p < 0.05) in simulated gastric fluid. Their metabolism is not mediated by cytochrome P-450 enzymes, but the depletion was inhibited by the esterase inhibitor NaF. Both diterpenes and their dialdehydes showed log P in the range of 3.6 to 4.0, suggesting high permeability. Metabolism kinetic data were fitted to the Michaelis-Menten profile with KM values of 61.4 μM and 66.4 μM and Vmax values of 327 and 648 nmol/min/mg of protein for cas B and casg F, respectively. Metabolism parameters in HLM were extrapolated to predict human hepatic clearance and suggest that casg F and cas B have a high hepatic extraction ratio. In conclusion, our data suggest that casg F and cas B present low oral bioavailability due to extensive gastric degradation and high hepatic extraction.

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Chemical variability and evaluation of physical parameters of the essential oil of the leaves of Casearia sylvestris varieties and morphoanatomical characterization of the leaves

et al. 2023

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Reserva Ecológica do IBGE (Brasília - DF): Flacourtiaceae

Cited by 8 publications

References 0 publications

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F

Chemical variability and evaluation of physical parameters of the essential oil of the leaves of Casearia sylvestris varieties and morphoanatomical characterization of the leaves

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