Sequence Analysis of the Arcelin-Phytohaemagglutinin-α-Amylase Inhibitor (APA) Locus in Three Phylogenetically Arrayed Phaseolus vulgaris Clones

Ferreira, Juliano Lino; Kami, James; Borém, Aluízio; Gepts, Paul

doi:10.1590/1984-70332022v22n4a50

Cited by 2 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arcelins are isolated seed proteins in wild bean accessions ( P. vulgaris L.). The arcelin sequence belong to the arcelin/phytohemagglutinin/a-amylase inhibitor (APA) family, that are all encoded in a single locus known as the APA locus [ 126 ]. Arcelins and α-amylase inhibitors share a similar three-dimensional structure as well as a high degree of sequence similarity with lectins, but lack carbohydrate binding sites.…”

Section: Plant Toxic Proteinsmentioning

confidence: 99%

Plant Toxic Proteins: Their Biological Activities, Mechanism of Action and Removal Strategies

Koçyiğit

Kocaadam-Bozkurt

Bozkurt

et al. 2023

Toxins

View full text Add to dashboard Cite

Plants evolve to synthesize various natural metabolites to protect themselves against threats, such as insects, predators, microorganisms, and environmental conditions (such as temperature, pH, humidity, salt, and drought). Plant-derived toxic proteins are often secondary metabolites generated by plants. These proteins, including ribosome-inactivating proteins, lectins, protease inhibitors, α-amylase inhibitors, canatoxin-like proteins and ureases, arcelins, antimicrobial peptides, and pore-forming toxins, are found in different plant parts, such as the roots, tubers, stems, fruits, buds, and foliage. Several investigations have been conducted to explore the potential applications of these plant proteins by analyzing their toxic effects and modes of action. In biomedical applications, such as crop protection, drug development, cancer therapy, and genetic engineering, toxic plant proteins have been utilized as potentially useful instruments due to their biological activities. However, these noxious metabolites can be detrimental to human health and cause problems when consumed in high amounts. This review focuses on different plant toxic proteins, their biological activities, and their mechanisms of action. Furthermore, possible usage and removal strategies for these proteins are discussed.

show abstract

Section: Plant Toxic Proteinsmentioning

confidence: 99%