Associação Do Estado Nutricional Com Função Pulmonar E Morbidade Em Crianças E Adolescentes Com Fibrose Cística: Coorte De 36 Meses

Abstract

Objective: To evaluate the association between nutritional status, lung function and morbidity in a 36-month cohort in children and adolescents with cystic fibrosis.Methods: Prospective cohort of children and adolescents with cystic fibrosis aged 1-15 years. At the baseline, the nutritional status was determined by weight-for-height and body mass index-for-age for children <2 years and ≥2 years, respectively, and classified as: nutritional failure, nutritional risk and acceptable; and by the 50th percentile, according to the World Health Organization (WHO) growth charts. Lung function was assessed by forced expiratory volume in one second (FEV1). Morbidity was determined by the presence of infection and hospitalization by pulmonary exacerbation. Risk ratio and 95% confidence interval (95%CI) were calculated, being significant when p<0.05.Results: We evaluated 38 children and adolescents (median age 3.8 years). Patients that were classified as having nutritional failure at baseline had a RR of 5.00 (95%CI 1.49; 16.76) to present impaired lung function after 36 months. Those classified bellow the 50th percentile had a RR of 4.61 (95%CI 0.89; 23.81) to present the same outcome. Nutritional status was not a risk factor for morbidity in this cohort.Conclusions: Nutritional deficit was associated with impaired lung function, but not with morbidity in children and adolescents with cystic fibrosis.

Prevalence and factors associated with overweight and obesity in adults with cystic fibrosis: A single-center analysis

“…Individuals with CF are classically at risk for malnutrition, which is related to inadequate intake, increased energy expenditure, and malabsorption [3] . Malnutrition is well-known to be associated with declining pulmonary function and high morbidity and mortality in this population [4][5][6][7] , and multiple studies have demonstrated that achieving an adequate weight is associated with improved pulmonary function and survival [8][9] . This has long been a focus of CF management, and European and North American CF guidelines recommend maintaining a BMI above 22 kg/m 2 in females and 23 kg/m 2 in males [10][11] .…”

Quality of anthropometric data measured in children and adolescents with cystic fibrosis: a scoping review

“…The most commonly cited reference populations were those of the Centers for Disease Control and Prevention (CDC) 14,[19][20][21]27,29,31,33,[40][41][42] and of the World Health Organization (WHO); 18,[22][23][24][25][26]37 however, references were also made to specific populations such as Italian, 11 Greek, 15 Egyptian, 16 Dutch, 35,38 and British. 39 The cutoff points adopted by the…”

“…Dual-energy X-ray absorptiometry authors 17,18,22,24,39,42 were mainly derived from consensuses or specific recommendations for CF subjects. 5,6,43,44…”

Fibrose Cística em uma análise genética, molecular e biológica / Cystic Fibrosis in a Genetic, Molecular and Biological Analysis

“…Nos pulmões e vias aéreas, a fibrose cística se manifesta por consequência da redução na absorção de cloro e o aumento na absorção de sódio, processo que resulta em espessamento e aumento da viscosidade do muco, acarretando prejuízo do clearance mucociliar e propicia ambiente favorável à colonização bacteriana. Além dessa suscetibilidade à infecção bacteriana, a retenção nos bronquíolos do muco de forma secundária gera manifestações de hipersecreção, tosse crônica e dispneia e, de forma mais grave, broquiectasia e insuficiência pulmonar (SANTOS et al, 2017;HAUSCHILD et al, 2018).…”