2018
DOI: 10.1590/1981-22562018021.170141
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Antidepressant use and the components of the frailty syndrome

Abstract: Objective: to evaluate the effects of antidepressant use on components of frailty. Methods: a cross-sectional and analytical study comparing groups of users and non-users of antidepressants was carried out in a municipal region in the south of Brazil. The research was linked to the matrix study "Health of Elderly Persons in Primary Care". The sample was selected through access to the database of the matrix study from which two groups were extracted: users (n=87) and non-users (n=114) of antidepressants. After… Show more

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Cited by 7 publications
(6 citation statements)
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“…Participants were recruited from community (67.9%) (23-41), primary care services (21.4%) (42)(43)(44)(45)(46)(47), outpatient clinics (7.1%) (48,49) and Universities of the Third Age (3.6%) (50). The number of participants ranged between 53 to 5,532 (total N = 17,604 older adults) and the mean age ranged from 65.6 to 85.5 years old.…”
Section: Overall Study Characteristicsmentioning
confidence: 99%
“…Participants were recruited from community (67.9%) (23-41), primary care services (21.4%) (42)(43)(44)(45)(46)(47), outpatient clinics (7.1%) (48,49) and Universities of the Third Age (3.6%) (50). The number of participants ranged between 53 to 5,532 (total N = 17,604 older adults) and the mean age ranged from 65.6 to 85.5 years old.…”
Section: Overall Study Characteristicsmentioning
confidence: 99%
“…E a classe dos antagonistas dos receptores alfa 2 agem bloqueando a recaptação aumentando a noradrenalina e seus efeitos são, aumento do apetite, sedação porque bloqueia HI. Esse grupo causa menos efeitos colaterais que os compostos tricíclicos (BANDEIRA, et al, 2018).…”
Section: Resultsunclassified
“…There are still gaps in relation to the usefulness of pharmacological and non-pharmacological interventions to improve the quality of life of older adults with the depressive frail phenotype, as well as to avoid a greater impact of depression in frail individuals, and vice versa. Nonetheless, the use of antidepressants could have serious adverse effects in frail and comorbid populations, such as an increased risk of hyponatremia, bleeding, vision disturbances, memory loss, delirium, and falls [ 49 , 50 ]. This situation highlights the need for more intervention studies including patients with the depressed frail phenotype due to the high risk of mortality.…”
Section: Discussionmentioning
confidence: 99%