Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

Abstract

Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging.

Relationship between muscle mass and muscle strength with physical performance in older adults: A systematic review

“…According to Macedo et al, 57 high levels of inflammatory mediators are predictors of a decline in functional capacity in older adults. This suggests that inflammation may play a role in the functional capacity of older adults, independent of muscle mass.…”

Estágio E a Formação Docente: A Importância Do Professor De Educação Física Na Educação Infantil

“…As diversas funções corporais, como manter o equilíbrio, depende do nível de força muscular (CHEN, CHOU, 2016). Quando esse se faz em nível alto, o indivíduo consegue manter a estabilização corporal, garantindo a capacidade de locomoção e mobilidade, que influenciam diretamente na competência de realização de diferentes funções, incluindo as primárias (MACEDO et al, 2018). Quando um indivíduo tem força muscular adequada para realização das suas demandas diária, diz-se que ele ainda é um indivíduo funcional, ou seja, que consegue manter uma certa independência na realização das funções básicas de autocuidado como locomover-se, tomar banho e comer (SILVA e FARINATTI, 2007).…”