Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

Padilha, Camila S.; Cella, Paola; Salles, L; Deminice, Rafael

doi:10.1590/1980-5918.030.004.ar01

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…Consequently, maintaining or increasing muscle creatine levels during periods of inactivity or recovery from injury may offer benefits [ 93 ]. Indeed, several studies have evaluated the potential effects of CrM supplementation during periods of immobilization [ 94 ] revealing: (i) Maintenance of muscle mass or cross-sectional area, muscle strength, and endurance; (ii) maintenance or increase in total muscle creatine concentration; (iii) maintenance of GLUT-4 concentration [ 95 ]; (iv) increased muscle glycogen; and (v) increased expression of growth factors (IGF-1) and myogenic regulatory factors [ 88 , 93 ]. However, it is difficult to draw definitive conclusions due to heterogeneity in study designs (e.g., duration, immobilized limb, experience level of participants, etc.).…”

Section: Discussionmentioning

confidence: 99%

Nutritional Strategies in the Rehabilitation of Musculoskeletal Injuries in Athletes: A Systematic Integrative Review

et al. 2023

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It is estimated that three to five million sports injuries occur worldwide each year. The highest incidence is reported during competition periods with mainly affectation of the musculoskeletal tissue. For appropriate nutritional management and correct use of nutritional supplements, it is important to individualize based on clinical effects and know the adaptive response during the rehabilitation phase after a sports injury in athletes. Therefore, the aim of this PRISMA in Exercise, Rehabilitation, Sport Medicine and Sports Science PERSiST-based systematic integrative review was to perform an update on nutritional strategies during the rehabilitation phase of musculoskeletal injuries in elite athletes. After searching the following databases: PubMed/Medline, Scopus, PEDro, and Google Scholar, a total of 18 studies met the inclusion criteria (Price Index: 66.6%). The risk of bias assessment for randomized controlled trials was performed using the RoB 2.0 tool while review articles were evaluated using the AMSTAR 2.0 items. Based on the main findings of the selected studies, nutritional strategies that benefit the rehabilitation process in injured athletes include balanced energy intake, and a high-protein and carbohydrate-rich diet. Supportive supervision should be provided to avoid low energy availability. The potential of supplementation with collagen, creatine monohydrate, omega-3 (fish oils), and vitamin D requires further research although the effects are quite promising. It is worth noting the lack of clinical research in injured athletes and the higher number of reviews in the last 10 years. After analyzing the current quantitative and non-quantitative evidence, we encourage researchers to conduct further clinical research studies evaluating doses of the discussed nutrients during the rehabilitation process to confirm findings, but also follow international guidelines at the time to review scientific literature.

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Section: Discussionmentioning

confidence: 99%

Nutritional Strategies in the Rehabilitation of Musculoskeletal Injuries in Athletes: A Systematic Integrative Review

et al. 2023

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“…Creatine consumption (e.g. 20 g/day for 5 days) has been reported to enhance phosphocreatine and muscle free creatine usually by 15 to 40 percent (56). It is indicated that creatine, can bind to the plasma membrane due to amphipathic nature, therewith increasing membrane stability and decrease CK and LDH loss (57).…”

Section: Discussionmentioning

confidence: 99%

Creatine Supplementation Effect on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

Liu

2020

Preprint

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Exercise-induced muscle damage (EIMD) causes to increased soreness, impaired function of muscles, and reductions in muscle force. Accumulating evidence suggests beneficial effects of creatine on EIMD. Nevertheless, outcomes differ substantially across various articles. The main aim of this meta analysis was to evaluate the effect of creatine on recovery following EIMD. Medline, Embase, Cochrane Library, Scopus and Google scholar were systematically searched up to July 2020. The Cochrane Collaboration tool for examining risk of bias was applied for assessing the quality of studies. Weighted mean difference (WMD), 95 percent confidence interval (CI) and random effects model, were applied for estimating the overall effect. Between studies heterogeneity was examined using the chi-squared and I2 statistic. Nine studies met the inclusion criteria. Pooled data showed that creatine significantly reduced CK concentration overall (WMD =-30.94; 95% CI:-53.19,-8.69; P = 0.006) and at three follow-up times 48, 72 and 96 hours) in comparison with placebo. In contrast, effects were not significant in LDH concentration overall (WMD =-5.99; 95% CI:-14.49, 2.50; P= 0.167), but creatine supplementation leaded to a significant reduction in LDH concentrations in trials with 48 hours measurement of LDH. The current data indicates that creatine consumption is better than rest after diverse forms of damaging and exhaustive exercise or passive recovery. The benefits relate to a decrease in muscle damage indices and Improved muscle function because of muscle power loss after exercise.

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“…Human dietary supplementation with GAA helps to increase muscle strength and endurance, and enhance athletic performance and release fatigue ( 5 ). Currently, creatine (Cr) and its precursor GAA have also been used in medical research for the treatment of muscle atrophy and neurodegenerative diseases ( 6 ). Furthermore, with the continuous improvement of people's living standards, the dietary structure has undergone significant changes, and the demand for meat product shifted from being quantity-satisfying to quality-ensuring.…”

Section: Introductionmentioning

confidence: 99%

Regulative Mechanism of Guanidinoacetic Acid on Skeletal Muscle Development and Its Application Prospects in Animal Husbandry: A Review

Yan

Liu

et al. 2021

Front. Nutr.

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Guanidinoacetic acid is the direct precursor of creatine and its phosphorylated derivative phosphocreatine in the body. It is a safe nutritional supplement that can be used to promote muscle growth and development. Improving the growth performance of livestock and poultry and meat quality is the eternal goal of the animal husbandry, and it is also the common demand of today's society and consumers. A large number of experimental studies have shown that guanidinoacetic acid could improve the growth performance of animals, promote muscle development and improve the health of animals. However, the mechanism of how it affects muscle development needs to be further elucidated. This article discusses the physical and chemical properties of guanidinoacetic acid and its synthesis pathway, explores its mechanism of how it promotes muscle development and growth, and also classifies and summarizes the impact of its application in animal husbandry, providing a scientific basis for this application. In addition, this article also proposes future directions for the development of this substance.

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Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

Cited by 5 publications

References 39 publications

Nutritional Strategies in the Rehabilitation of Musculoskeletal Injuries in Athletes: A Systematic Integrative Review

Nutritional Strategies in the Rehabilitation of Musculoskeletal Injuries in Athletes: A Systematic Integrative Review

Creatine Supplementation Effect on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

Regulative Mechanism of Guanidinoacetic Acid on Skeletal Muscle Development and Its Application Prospects in Animal Husbandry: A Review

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