Language in corticobasal syndrome: a systematic review

Almeida, Isabel Junqueira de; Silagi, Marcela Lima; Parmera, Jacy Bezerra; Brucki, Sônia Maria Dozzi; Schochat, Eliane

doi:10.1590/1980-57642021dn15-010002

Cited by 4 publications

(5 citation statements)

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“…Besides motor symptoms, cognitive and behavioral disturbances are common and often recognized as the first presentation in CBS ( 13 , 14 ). Additionally, prominent language dysfunction is usually present from the early stages or during the disease course ( 1 , 15 , 16 ) and incorporated into previous diagnostic criteria ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study

et al. 2021

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Introduction: Corticobasal syndrome (CBS) is a progressive neurological disorder related to multiple underlying pathologies, including four-repeat tauopathies, such as corticobasal degeneration and progressive supranuclear palsy, and Alzheimer's disease (AD). Speech and language are commonly impaired, encompassing a broad spectrum of deficits. We aimed to investigate CBS speech and language impairment patterns in light of a multimodal imaging approach.Materials and Methods: Thirty-one patients with probable CBS were prospectively evaluated concerning their speech–language, cognitive, and motor profiles. They underwent positron emission tomography with [18F]fluorodeoxyglucose (FDG-PET) and [11C]Pittsburgh Compound-B (PIB-PET) on a hybrid PET-MRI machine to assess their amyloid status. PIB-PET images were classified based on visual and semi-quantitative analyses. Quantitative group analyses were performed on FDG-PET data, and atrophy patterns on MRI were investigated using voxel-based morphometry (VBM). Thirty healthy participants were recruited as imaging controls.Results: Aphasia was the second most prominent cognitive impairment, presented in 67.7% of the cases, following apraxia (96.8%). We identified a wide linguistic profile, ranging from nonfluent variant-primary progressive aphasia to lexical–semantic deficits, mostly with impaired verbal fluency. PIB-PET was classified as negative (CBS-A– group) in 18/31 (58%) and positive (CBS-A+ group) in 13/31 (42%) patients. The frequency of dysarthria was significantly higher in the CBS-A– group than in the CBS-A+ group (55.6 vs. 7.7%, p = 0.008). CBS patients with dysarthria had a left-sided hypometabolism at frontal regions, with a major cluster at the left inferior frontal gyrus and premotor cortex. They showed brain atrophy mainly at the opercular frontal gyrus and putamen. There was a positive correlation between [18F]FDG uptake and semantic verbal fluency at the left inferior (p = 0.006, R2 = 0.2326), middle (0.0054, R2 = 0.2376), and superior temporal gyri (p = 0.0066, R2 = 0.2276). Relative to the phonemic verbal fluency, we found a positive correlation at the left frontal opercular gyrus (p = 0.0003, R2 = 0.3685), the inferior (p = 0.0004, R2 = 0.3537), and the middle temporal gyri (p = 0.0001, R2 = 0.3993).Discussion: In the spectrum of language impairment profile, dysarthria might be helpful to distinguish CBS patients not related to AD. Metabolic and structural signatures depicted from this feature provide further insights into the motor speech production network and are also helpful to differentiate CBS variants.

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Section: Introductionmentioning

confidence: 99%

Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study

et al. 2021

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“…To facilitate treatment planning and evaluation of progress in clinical, research, or community settings, stroke populations need to be comprehensively evaluated. Facing the increasing demand for stroke rehabilitation 3 , the Research Outcome Measurement in Aphasia (ROMA) consensus statement suggested WAB-Revised as the measurement of clinical outcomes 4 , and the WAB of the linguistic deficit is the most widely used assessment to measure PSA in the research context 5 , 6 . The WAB-AQ score has been used as an inclusion criterion and as an outcome measure for clinical trials 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia

Yan

Wei

Zhang

et al. 2022

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The aphasia quotient of Western Aphasia Battery (WAB-AQ) has been used as an inclusion criterion and as an outcome measure in clinical, research, or community settings. The WAB-AQ is also commonly used to measure recovery. This study aimed to quantitatively determine levels of the linguistic deficit by using a cluster analysis of the WAB-AQ in post-stroke aphasia (PSA). 308 patients were extracted from the database. Cutoff scores are defined by mean overlap WAB-AQ scores of clusters by systematic cluster analysis, the method of which is the farthest neighbor element, and the metrics are square Euclidean distance and Pearson correlation, performed on the full sample of WAB-AQ individual subitem scores. A 1-way analysis of variance, with post hoc comparisons conducted, was used to determine whether clusters had significant differences. Three clusters were identified. The scores for severe, moderate, and mild linguistic deficit levels ranged from 0 to 30, 30.1 to 50.3, and 50.4 to 93.7, respectively. For PSA, the cluster analysis of WAB-AQ supports a 3-impairment level classification scheme.

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“…Additionally, we aim at investigating whether discursive measures can contribute on the differentiation between CBS patients with and without AD underlying pathology, based on a brain metabolic dichotomized analysis using positron emission tomography with [ 18 F]fluorodeoxyglucose (FDG-PET) and in the presence or absence of amyloid deposition using amyloid-PET. Previous studies have described the heterogeneity of language disorders in CBS patients [ 14 , 15 ]; therefore, we hypothesize that, as a group, CBS patients will present deficits in all language levels. Concerning the differentiation of CBS clinical profiles associated or not with AD underlying pathology, based on previous studies (e.g., [ 11 ]), we hypothesize that CBS patients with AD pathology will present a clinical profile similar to the lvPPA, with more lexical retrieval deficits, while CBS not related to AD pathology (i.e., tauopathology) will have a clinical profile similar to the nfvPPA, with more motor speech and morphosyntactic deficits.…”

Section: Introductionmentioning

confidence: 96%

“…CBS may cause impairments in all language processing levels, and previous research could not identify a unique pattern of change [ 14 , 15 ]. Most studies reported a phenotype similar to the non-fluent variant of primary progressive aphasia (nfvPPA) [ 16 , 17 , 18 ], whereas others reported a wide variety of phenotypes: Broca’s aphasia, anomic aphasia, fluent aphasia, mixed aphasia and logopenic variant of PPA (lvPPA) [ 2 , 10 , 15 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Differences in connected speech measures have been evidenced between typical and pathological cognitive aging, and between distinct neurodegenerative syndromes [ 25 ]. However, most studies with CBS patients have not included discourse analysis, restricting their assessment to decontextualized language production tasks, such as confrontation naming, verbal fluency, and repetition [ 14 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach

et al. 2022

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The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS probably due to Alzheimer’s disease (CBS-AD) pathology and CBS not related to AD (CBS-non-AD) in the same measures, based on the brain metabolic status (FDG-PET) and in the presence of amyloid deposition (amyloid-PET). Results showed that CBS patients were significantly different from controls in speech rate, lexical level, informativeness, and syntactic complexity. Discursive measures did not differentiate CBS-AD from CBS-non-AD. However, CBS-AD displayed more lexical-semantic impairments than controls, a profile that is frequently reported in patients with clinical AD and the logopenic variant of primary progressive aphasia (lvPPA). CBS-non-AD presented mainly with impairments related to motor speech disorders and syntactic complexity, as seen in the non-fluent variant of PPA.

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Language in corticobasal syndrome: a systematic review

Cited by 4 publications

References 54 publications

Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study

Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study

Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia

The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach

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