[18F]FDG-PET in a case of right temporal lobe variant of frontotemporal dementia

Brito, Marcelo Houat de; Teixeira, Thiago Bezerra Moraes; Zampieri, Poliana Fonseca; Coutinho, Artur Martins; Brucki, Sônia Maria Dozzi

doi:10.1590/1980-57642018dn13-030013

Cited by 2 publications

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“…Case report rtvFTD should be considered in elderly patients with altered behavioral and problems with interpersonal relationships, even if dementia is not suspected Brito et al 36 1 Case report rtvFTD patient presenting slowly progressive amnestic and topographical disorientation symptoms, followed by an early onset of apathy, hyperorality, ritualistic behaviors, prosopagnosia, and phonagnosia evaluation process, 41 articles were selected, published between 1993 and 2021. We found that rtvFTD presents with severe and progressive prosopagnosia (related to anterior temporal lobe injury) associated with behavioral symptoms-desinibition (51%), apathy (39%), obsessive-compulsive symptoms (37%), changes in eating habits (33%), and depression (28%), which is different from semantic dementia.…”

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Right Temporal Lobe Variant of Frontotemporal Dementia

Campos

Rocca

Caixeta

2022

Alzheimer Disease &Amp; Associated Disorders

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Frontotemporal dementia corresponds to a heterogenous group of syndromes characterized by progressive changes in behavior and/or language. Approximately 30% of patients with primary progressive aphasia, semantic variant (semantic dementia), present with atrophy in the right cerebral hemisphere, in a rare clinical condition called right temporal variant of frontotemporal dementia (rtvFTD). The objective of the study is to present the main demographic, clinical, neuropsychological, neuroimaging, and pathologic characteristics of rtvFTD patients. A systematic review of the literature was carried out in the PubMed, LILACS, and SCIELO databases between January and March 2022. After the evaluation process, 41 articles were selected, published between 1993 and 2021. We found that rtvFTD presents with severe and progressive prosopagnosia (related to anterior temporal lobe injury) associated with behavioral symptoms—desinibition (51%), apathy (39%), obsessive-compulsive symptoms (37%), changes in eating habits (33%), and depression (28%), which is different from semantic dementia. The most common pathologic pattern is TDP-43, type C. This field of knowledge has few studies (mainly reports and case series) and heterogenous nomenclature, which is a limitation. A multinational longitudinal registry of people with rtvFTD, with standardized assessment and description of symptoms, is necessary to elucidate the characteristics of this entity.

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confidence: 99%