Association between diabetes and causes of dementia: Evidence from a clinicopathological study

Matioli, Maria Niures Pimentel dos Santos; Suemoto, Cláudia Kimie; Rodriguez, Roberta Diehl; Farias, Daniela Souza; Silva, Magnólia Moreira da; Leite, Renata Elaine Paraízo; Ferretti-Rebustini, Renata Eloah de Lucena; Pasqualucci, Carlos Augusto; Grinberg, Lea T.; Nitrini, Ricardo

doi:10.1590/1980-57642016dn11-040010

Cited by 16 publications

(24 citation statements)

References 48 publications

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“…This agrees with some studies that have not only shown a different pattern between T2D-MCI and ND-MCI, but also a different trend over time: while T2D-MCI usually remains stable, ND-MCI tends to get worse especially in the amnesic components [ 45 , 46 ]. However, different neuropathological studies showed inconclusive results, not finding an increased frequency of any particular type of dementia in diabetic patients submitted to autopsy [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

Valenza

Paciaroni

Paolini

et al. 2020

JCM

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Background: Type 2 diabetes (T2D) is correlated to amnestic mild cognitive impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This study evaluated whether the T2D variable characterizes a peculiar cognitive profile in elderly patients. Moreover, it explores the association between glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic agent treatment, and cognition in elderly diabetic patients. Methods: Detailed neuropsychological battery was used to diagnose MCI subtypes. A total of 39 MCI subjects with T2D (T2D-MCI) and 37 MCI subjects without T2D (ND-MCI), matched for age, educational level, and Mini-Mental State Examination score, were included. Results: ND-MCI performed worse in memory and language domains than T2D-MCI. The amnestic subtype is more frequent among ND-MCI and non-amnestic subtype in T2D-MCI. In T2D-MCI, high HbA1c levels correlate with episodic memory (immediate recall) and T2D duration. Some indexes of episodic memory (immediate recall), attention, and visual-spatial ability correlate with insulin treatment. Conclusions: An association between T2D and non-amnestic MCI is suggested. In the T2D-MCI group, significant associations between insulin treatment and memory (immediate recall), complex figure copy, and attention were found.

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Section: Discussionmentioning

confidence: 99%

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

Valenza

Paciaroni

Paolini

et al. 2020

JCM

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“…The large majority of autopsy (neuropathologic) studies report no association between T2DM and amyloid plaques or NFTs (3,11,14,36,73,82,114,115,127,141,176). A recent multi-center study evaluated 2365 autopsied patients with >1300 patients having available cognitive data (2).…”

Section: T2dm Association With Clinically- and Pathologically-defined Admentioning

confidence: 99%

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

et al. 2018

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Alzheimer's disease (AD) and type-2 diabetes mellitus (T2DM) are highly prevalent aging-related diseases associated with significant morbidity and mortality. Some findings in human and animal models have linked T2DM to AD-type dementia. Despite epidemiological associations between the T2DM and cognitive impairment, the interrelational mechanisms are unclear. The preponderance of evidence in longitudinal studies with autopsy confirmation have indicated that vascular mechanisms, rather than classic AD-type pathologies, underlie the cognitive decline often seen in self-reported T2DM. T2DM is associated with cardiovascular and cerebrovascular disease (CVD), and is associated with increased risk of infarcts and small vessel disease in the brain and other organs. Neuropathological examinations of post-mortem brains demonstrated evidence of cerebrovascular disease and little to no correlation between T2DM and β-amyloid deposits or neurofibrillary tangles. Nevertheless, the mechanisms upstream of early AD-specific pathology remain obscure. In this regard, there may indeed be overlap between the pathologic mechanisms of T2DM/"metabolic syndrome," and AD. More specifically, cerebral insulin processing, glucose metabolism, mitochondrial function, and/or lipid metabolism could be altered in patients in early AD and directly influence symptomatology and/or neuropathology.

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“…Diabetes mellitus type 2 (DM2) in midlife is a risk factor for dementia, and this association is stronger in persons of African ancestry [2–4]. Occurrence of DM2 in midlife and other factors listed previously are known to accelerate development of dementia in Africa Americans [2,5] compared with Caucasians [2–4,6–8]. It is worrisome that the prevalence of DM2 will increase astronomically in the next few years; with 75% of the cases living in low‐to‐middle–income countries (LMICs), including Nigeria [1].…”

Section: Introductionmentioning

confidence: 99%

Short height and poor education increase the risk of dementia in Nigerian type 2 diabetic women

Oghagbon

2019

Alz & Dem Diag Ass & Dis Mo

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Introduction There is urgent need to investigate type 2 diabetes and dementia crosstalk in sub-Saharan African countries with special attention to women who have higher vulnerability. Nigeria which has the highest number of diabetics on the African continent is a good location for the investigation. Methods Biophysical parameters, occupation, education, burden of diabetes mellitus, cardiovascular health, and cognition were evaluated in 102 type 2 diabetics and 99 controls. Results Short physical stature and lower level of education were hallmarks of diabetes in females. Two dementia scales (Mini–Mental State Examination and six-item Cognitive Impairment Test) showed cognitive impairment status, with the six-item Cognitive Impairment Test scale being more specific and sensitive. Both scales showed correlations with age, education, weight, height, and disease onset, whereas fasten blood glucose was negatively correlated with height and their blood pressure was normal. Discussion Height, an easy-to-measure parameter in Nigeria, may reveal increased risk of dementia in poorly educated female Nigerian diabetics, thus helping to improve preventive and therapeutic interventions.

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Association between diabetes and causes of dementia: Evidence from a clinicopathological study

Cited by 16 publications

References 48 publications

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Short height and poor education increase the risk of dementia in Nigerian type 2 diabetic women

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