Multimodality Imaging Approach in Alzheimer disease. Part I: Structural MRI, Functional MRI, Diffusion Tensor Imaging and Magnetization Transfer Imaging

Promteangtrong, Chetsadaporn; Kolber, Marcus; Ramchandra, Priya; Moghbel, Mateen; Houshmand, Sina; Schöll, Michael; Bai, Halbert; Werner, Thomas; Alavi, Abass; Buchpiguel, Carlos Alberto

doi:10.1590/1980-57642015dn94000318

Cited by 14 publications

(8 citation statements)

References 114 publications

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“…This would involve two novel processes that remain to be demonstrated: that qMT parameters, and PSR in particular, do not follow a monotonic course as PD progresses; and that changes in PSR differs from those of MTR under some circumstances. The proposed progression of PSR and MTR would be consistent with reports of increases in PSR [51, 52] and reductions in MTR [53] for brain regions altered by Alzheimer disease, another disease characterized by macromolecule accumulation even prior to onset of neuronal death. Notably, qMT parameters other than PSR, including exchange rate and relaxation time ratios that did not show significant differences between HC and PD patients in our cohort, have been seen to be correlate with Alzheimer disease progression [62, 63].…”

Section: Discussionsupporting

confidence: 87%

Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches

et al. 2017

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Purpose We sought to measure quantitative magnetization transfer (qMT) properties of the substantia nigra pars compacta (SNc) in patients with Parkinson’s disease (PD) and healthy controls (HCs) using a full qMT analysis and determine whether a rapid single-point measurement yields equivalent results for pool size ratio (PSR). Methods Sixteen different MT-prepared MRI scans were obtained at 3T from sixteen PD patients and eight HCs, along with B1, B0 and relaxation time maps. Maps of PSR, free and macromolecular pool transverse relaxation times ( T2f, T2m) and rate of MT exchange between pools ( kmf) were generated using a full qMT model. PSR maps were also generated using a single-point qMT model requiring just two MT-prepared images. qMT parameter values of the SNc, red nucleus, cerebral crus and grey matter were compared between groups and methods. Results PSR of the SNc was the only qMT parameter to differ significantly between groups (p<0.05). PSR measured via single-point analysis was less variable than with the full MT model, provided slightly better differentiation of PD patients from HCs (area under curve 0.77 vs. 0.75) with sensitivity and specificity of 0.87, and was better than transverse relaxation time in distinguishing PD patients from HCs (area under curve 0.71, sensitivity 0.87 and specificity 0.50). Conclusions The increased PSR observed in the SNc of PD patients may provide a novel biomarker of PD, possibly associated with an increased macromolecular content. Single-point PSR mapping with reduced variability and shorter scan times relative to the full qMT model appears clinically feasible.

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Section: Discussionsupporting

confidence: 87%

Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches

et al. 2017

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“…Magnetic resonance imaging (MRI) is essential for early diagnosis of AD (Matsuda, 2017), including conventional MRI, diffusion tension imaging (DTI) (Promteangtrong et al, 2015), proton magnetic resonance spectroscopy (MRS) (Zhang N. et al, 2014). The accuracy of AD diagnosis may be increased using advanced MRI techniques.…”

Section: Introductionmentioning

confidence: 99%

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Wang

Chen

Shen

et al. 2019

Front. Aging Neurosci.

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Amyloid-β (Aβ) deposits and some proteins play essential roles in the pathogenesis of Alzheimer's disease (AD). Amide proton transfer (APT) imaging, as an imaging modality to detect tissue protein, has shown promising features for the diagnosis of AD disease. In this study, we chose 10 AD model rats as the experimental group and 10 sham-operated rats as the control group. All the rats underwent a Y-maze test before APT image acquisition, using saturation with frequency alternating RF irradiation (APT SAFARI) method on a 7.0 T animal MRI scanner. Compared with the control group, APT (3.5 ppm) values of brain were significantly reduced in AD models (p < 0.002). The APT SAFARI imaging is more significant than APT imaging (p < 0.0001). AD model mice showed spatial learning and memory loss in the Y-maze experiment. In addition, there was significant neuronal loss in the hippocampal CA1 region and cortex compared with sham-operated rats. In conclusion, we demonstrated that APT imaging could potentially provide molecular biomarkers for the non-invasive diagnosis of AD. APT SAFARI MRI could be used as an effective tool to improve the accuracy of diagnosis of AD compared with conventional APT imaging.

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“…Due to severe overlap in symptoms and findings of individual imaging modalities of the neurodegenerative diseases, it is difficult to identify the biomarkers that could be used to differentiate the types of these diseases and/or to stage the progress of a disease. Therefore, multimodal neuroimaging techniques are used to overcome the challenges [110] . As pointed out in [111] , individual modalities of MRI and EEG lack precision in AD diagnosis and staging.…”

Section: Multimodal Imaging Data Fusion: Diseasesmentioning

confidence: 99%

Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

et al. 2020

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Highlights We analysed over 450 references from all well-famed databases. We provided a comprehensive survey on multimodal data fusion in neuroimaging. This review encompassed current challenges & applications, strengths &limitations. Fundamental fusion rules, and fusion quality assessment methods were reviewed. Atlas-based fusion segmentation, quantification, & applications were reviewed.

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Multimodality Imaging Approach in Alzheimer disease. Part I: Structural MRI, Functional MRI, Diffusion Tensor Imaging and Magnetization Transfer Imaging

Cited by 14 publications

References 114 publications

Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches

Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

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