Mortality trend and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso

Abstract

Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil.

Dual Inhibition of PI3K/Akt/mTOR Signaling Pathway in Leukemic Cell Lines Upregulates Long Non-Coding RNAs RNCR3 UCA1 and HULC

“…Leukemias are a group of malignant cancers of hematological stem cells involving bone marrow and other hematopoietic organs yielding high number of immature or abnormal leukocytes [1,2] . In total of around 12 types of malignant neoplasms, leukocytes are grouped under leukemias, where the most common types are Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) that accumulate cancerous cells in the bone marrow [3] . As per the recent 2021 report of Global Cancer Observatory (GLOBOCAN), it is estimated that leukemias are the 15 th most diagnosed neoplasms worldwide, where the total of 311 594 death cases were reported out of 474 519 diagnosed cases [4] .…”