Structural Characterization of Calcium Sulfate Bone Graft Substitute Cements

Favvas, Evangelos P.; Stefanopoulos, K.L.; Vordos, N.; Drosos, George; Mitropoulos, A.Ch.

doi:10.1590/1980-5373-mr-2015-0670

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…18 Nevertheless, the advantages of the antibiotic elution properties of absorbable ceramic bone cements over those of PMMA remain to be proven. 18,19 Orsini et al 20 and Favvas et al 21 demonstrated that in the form of cement and/or microspheres, calcium sulfate is effectively absorbed by the body and acts directly as a calcium supplier at the affected site, favoring osteogenesis. In addition to being used as a bone void filler, calcium sulfate may also work as an antimicrobial carrier in the body.…”

Section: Introductionmentioning

confidence: 99%

In vitro elution characteristics of antibiotic‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections

et al. 2023

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Polymethylmethacrylate (PMMA) remains the gold standard antibiotic carrier in the management of osteomyelitis. However, biodegradable ceramic carriers may exhibit more efficient antibiotic elution properties. Through zone of inhibition (ZOI) testing and biofilm killing assays, we assessed the in vitro elution efficacy of vancomycin released from calcium sulfate (PG-CSH) and PMMA beads as carriers on clinical strains of Staphylococcus aureus and Staphylococcus epidermidis, which were isolated from sonication fluid of orthopedic implant-associated infections. Overall, vancomycin-loaded PMMA and PG-CSH beads showed potency (ZOI above 4 cm 2 ) for up to 14 days against ATCC and clinical strains. Vancomycin-loaded PG-CSH beads displayed higher rates, exhibited a more stable antibiotic elution, had greater impacts on bacterial colony-forming unit counts and produced higher ZOIs; additionally, statistically significant differences (Student's t test) were observed in different time sets during the experiment. In the biofilm killing assay, PG-CSH loaded with vancomycin resulted in more bacterial deaths. In conclusion, in the present study, both PG-CSH and PMMA beads acted as good carriers, but greater antimicrobial elution and biofilm bacterial killing were observed with PG-CSH than PMMA. Future in vitro research should focus on testing other difficult-to-treat clinical strains, including multidrug resistant coagulase-negative staphylococci and Gram-negative bacilli.

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Section: Introductionmentioning

confidence: 99%

In vitro elution characteristics of antibiotic‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections

et al. 2023

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“…Calcium sulfate (CS) is a widely used artificial bioceramic material, and the CS used for bone repair materials is, generally, calcium sulfate hemihydrate (CSH) [3,4]. However, the rate of CS degradation in vivo is too fast and does not match the rate of new bone formation, while the degradation products of CS are acidic, which is detrimental to cell growth and proliferation [5,6]. There are many additions that can be used to improve the bioactivity of CS, which further stabilized the pH of the surrounding environment and regulated the degradation rate, such as calcium carbonate [7], bioactive glass [8,9], and calcium silicate [10,11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Platelet-Rich Plasma Addition on the Chemical Properties and Biological Activity of Calcium Sulfate Hemihydrate Bone Cement

et al. 2023

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Currently, platelet-rich plasma (PRP) is an attractive additive for bone repair materials. PRP could enhance the osteoconductive and osteoinductive of bone cement, as well as modulate the degradation rate of calcium sulfate hemihydrate (CSH). The focus of this study was to investigate the effect of different PRP ratios (P1: 20 vol%, P2: 40 vol%, and P3: 60 vol%) on the chemical properties and biological activity of bone cement. The injectability and compressive strength of the experimental group were significantly higher than those of the control. On the other hand, the addition of PRP decreased the crystal size of CSH and prolonged the degradation time. More importantly, the cell proliferation of L929 and MC3T3-E1 cells was promoted. Furthermore, qRT-PCR, alizarin red staining, and western blot analyses showed that the expressions of osteocalcin (OCN) and Runt-related transcription factor 2 (Runx2) genes and β-catenin protein were up-regulated, and mineralization of extracellular matrix was enhanced. Overall, this study provided insight into how to improve the biological activity of bone cement through PRP incorporation.

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“…Calcium sulfate dihydrate (CaSO 4 ·2H 2 O), known as gypsum, has been approved by the U.S. Food and Drug Administration for clinical use to reconstruct bone defects [ 3 ]. Gypsum has the ability to undergo in situ setting after filling the defect, has good biocompatibility, and promotes bone healing [ 4 ]. In addition, gypsum can be produced by mixing CaSO 4 ·0.5H 2 O powder and water.…”

Section: Introductionmentioning

confidence: 99%

Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats

et al. 2018

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The purpose of this study was to evaluate the feasibility of using apatite blocks fabricated by a dissolution–precipitation reaction of preset gypsum, with or without statin, to enhance bone formation during socket healing after tooth extraction. Preset gypsum blocks were immersed in a Na3PO4 aqueous solution to make hydroxyapatite (HA) low crystalline and HA containing statin (HAFS), or in a mixed solution of Na2HPO4 and NaHCO3 to make carbonate apatite (CO) and CO containing statin (COFS). The right mandibular incisors of four-week-old male Wistar rats were extracted and the sockets were filled with one of the bone substitutes or left untreated as a control (C). The animals were sacrificed at two and four weeks. Areas in the healing socket were evaluated by micro-computed tomography (micro-CT) and histological analyses. The bone volume, trabecular thickness, and trabecular separation were greatest in the COFS group, followed by the CO, HAFS, HA, and C groups. The bone mineral density of the COFS group was greater than that of the other groups when evaluated in the vertical plane. The results of this study suggest that COFS not only allowed, but also promoted, bone healing in the socket. This finding could be applicable for alveolar bone preservation after tooth extraction.

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Structural Characterization of Calcium Sulfate Bone Graft Substitute Cements

Cited by 10 publications

References 23 publications

In vitro elution characteristics of antibiotic‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections

In vitro elution characteristics of antibiotic‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections

Effect of Platelet-Rich Plasma Addition on the Chemical Properties and Biological Activity of Calcium Sulfate Hemihydrate Bone Cement

Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats

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