Implicações da imunossenescência na vacinação de idosos

Malafaia, Guilherme

doi:10.1590/1809-9823.2008.110311

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…This finding is in line with those reported in other studies conducted for different countries [ 14 , 38 , 39 , 40 ], and it can be interpreted due to the influence of immunosenescence (immune aging), which negatively contributes to a low immune response to vaccination of the elderly. Notice that this immunological fact is not unique to anti-COVID-19 vaccines, occurring with influenza, pneumonia, tetanus, and hepatitis B vaccines as well [ 41 ]. In addition, there is also reduced immunological memory generation in individuals with advantageous age, as well as the loss of antibodies, making this particular group more susceptible to infection [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Notice that this immunological fact is not unique to anti-COVID-19 vaccines, occurring with influenza, pneumonia, tetanus, and hepatitis B vaccines as well [ 41 ]. In addition, there is also reduced immunological memory generation in individuals with advantageous age, as well as the loss of antibodies, making this particular group more susceptible to infection [ 41 ]. The above-discussed issues together with the results presented in Section 3 further reinforce the importance of periodic immunization campaigns prioritizing specific groups of people, such as the elderly population.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

et al. 2022

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Considering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand the impact of the disease on the most vulnerable groups and those at risk of death from the disease. To this end, the odds ratio (OR) for mortality and hospitalization was calculated for different groups of patients by applying an adjusted logistic regression model based on the following variables of interest: gender, booster vaccination, age group, and comorbidity occurrence. A massive number of data were extracted and compiled from official Brazilian government resources, which include all reported cases of hospitalizations and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Brazil during the “wave” of the Omicron variant (BA.1 substrain). Males (1.242; 95% CI 1.196–1.290) aged 60–79 (3.348; 95% CI 3.050–3.674) and 80 years or older (5.453; 95% CI 4.966–5.989), and hospitalized patients with comorbidities (1.418; 95% CI 1.355–1.483), were more likely to die. There was a reduction in the risk of death (0.907; 95% CI 0.866–0.951) among patients who had received the third dose of the anti-SARS-CoV-2 vaccine (booster). Additionally, this big data investigation has found statistical evidence that vaccination can support mitigation plans concerning the current scenario of COVID-19 in Brazil since the Omicron variant and its substrains are now prevalent across the entire country.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

et al. 2022

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“…Serology for sporotrichosis is based on antibody detection (mainly IgG) tests and provides a presumptive diagnosis of this mycotic disease [ 38 ]. In this study, this test showed an excellent sensitivity (97.1%) with respect to the study population, although in cases of immunosenescence, there may be a reduction in the number of B cells with a decrease in antibody production, as seen, for example, in the decrease in the immune response to many vaccines [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil

Gomes,

do Valle,

Freitas

et al. 2023

JoF

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Generally, older people tend to suffer from more severe infections than younger adults. In addition, there are accumulations of comorbidities and immune senescence in some cases. This cohort study evaluated the clinical and epidemiological characteristics of older adults (≥60 years old) with sporotrichosis. The cohort consisted of 911 patients with a median age of 67 years, most of whom were female (72.6%), white (62.1%), and afflicted with comorbidities (64.5%). The lymphocutaneous form occurred in 62% of the patients, followed by the fixed form (25.7%), cutaneous disseminated form (8.9%), and extracutaneous/disseminated forms (3.3%). In this study, we draw attention to the frequency of osteoarticular involvement (2.1%) secondary to skin lesions such as osteomyelitis and/or tenosynovitis. A clinical cure was achieved in 87.3% of cases. Itraconazole was used in 81.1% of cases, while terbinafine was used in 22.7% of cases, usually in low doses. Survival analysis showed that the median treatment time was 119 days, and the multiple Cox model demonstrated that the presentation of a black coloration and diabetes was associated with a longer treatment time required to establish a cure. Therefore, these subgroups should be monitored more closely to reduce possible difficulties during treatment. It would be interesting to conduct more studies analyzing older adults with sporotrichosis from different geographic areas to better comprehend the disease in this group.

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“…Todas essas modificações podem estabelecer a perda de conseguir se adaptar às condições do meio (GUILLEN et al, 2009). Desta forma, a vacinação é a forma mais eficaz contra gripes entre outras doenças que podem acometer essa população específica que possui certo grau de vulnerabilidade, visando prevenir complicações evitáveis nos idosos (MALAFAIA, 2008).…”

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Análise da cobertura vacinal do município de Maringá e da 15ª região de saúde do Paraná

Carvalho¹,

Giacometti²

2023

Medicina Em Foco Explorando Os Avanços E as Fronteiras Do Conhecimento

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A imunização é compreendida como um processo de intervenção no estado de saúde-doença, tendo grande importância para a promoção da saúde na população. Posto isto, é considerada uma das formas mais seguras e eficientes quando se trata de prevenção e redução de diversas doenças. Atualmente, há movimentos contra a vacinação da população que prejudicam o objetivo proposto pelo Programa Nacional de Imunização (PNI). Diante de toda conjuntura vivenciada e debatida por muitos, a pesquisa tem como objetivo, analisar a cobertura vacinal do município de Maringá-PR e da 15ª Região de Saúde do Paraná, no período de 2016 a 2022, e colaborar com a disseminação do conhecimento e atualização acerca do programa vacinal. Com isso, optou-se por utilizar uma metodologia de estudo descritivo como forma de expor os dados da pesquisa. Por fim, com os resultados encontrados, foi possível observar que há necessidade de maior divulgação e promoção sobre a vacinação. Assim, incentiva-se a criação de movimentos de fortalecimento das políticas de saúde no âmbito municipal e regional.

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Implicações da imunossenescência na vacinação de idosos

Cited by 4 publications

References 33 publications

Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil

Análise da cobertura vacinal do município de Maringá e da 15ª região de saúde do Paraná

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