Avaliação da toxicidade aguda pré-clínica do extrato metanólico das cascas do caule de Parahancornia amapa (Apocynaceae)

Silva, Simoni Lobato da; Nascimento, Alessandra Azevedo do; Ribeiro, Edson Fábio Brito; Ribeiro, Renata Barbosa; Alves, Cleiziane Melo; Santos, André Mendonça dos; Burmann, Aurélio Pinheiro Rodrigues; Neto, Raimundo de Almeida Mira

doi:10.1590/1809-4392201501746

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…Segundo Sharley et al (2008) [25] tomar uma colher de sobremesa (5 mL) em um copo de água (250 mL) em jejum uma vez ao dia durante 30 dias em casos como bronquite, asma, pneumonia, gastrite, úlcera, inflamações do útero e fortificante, mas no tratamento de tuberculose tomar por 90 dias. Avaliação de toxidade do leite de amapá em humanos faz-se necessária, porém em condições laboratoriais, usando camarões de salmoura (Artemia salina) e ratos Wistar, os resultados sugeriram que o extrato de P. fasciculata teve um efeito geral não-tóxico [26].…”

Section: Discussionunclassified

Etnobotânica de Parahancornia fasciculata (Apocynaceae): extração, usos e comercialização do leite de amapá na comunidade da ilha Trambioca, Barcarena, Pará, Brasil

Sousa

Costa

et al. 2019

Sci. Plena

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A espécie Parahancornia fasciculata produz um exsudato medicinal na forma de látex, denominado leite de amapá amargoso, bastante utilizado na Amazônia brasileira por suas propriedades medicinais. O presente trabalho teve como objetivo estudar as formas de extração, os usos e a comercialização do leite de amapá na comunidade da ilha Trambioca, Barcarena-PA. Os colaboradores foram selecionados por uma abordagem não probabilística “bola de neve”. A extração do leite de amapá pelos moradores da ilha Trambioca é exercida por homens com idade entre 39 a 76 anos e a cadeia de extração, consumo e comercialização do leite de amapá na ilha envolve o extrator, o atravessador e os consumidores local e externo. Os consumidores do exsudato obtido do amapazeiro abrangeram todas as faixas etárias entrevistadas, mais da metade (64%) tinham renda de até dois salários mínimos e tomaram o leite de amapá devido a facilidade de conseguir o produto e por ser natural. O látex de amapá possui propriedades farmacológicas para o tratamento de doenças que afetam o sistema respiratório e fraqueza física.

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Section: Discussionunclassified

Etnobotânica de Parahancornia fasciculata (Apocynaceae): extração, usos e comercialização do leite de amapá na comunidade da ilha Trambioca, Barcarena, Pará, Brasil

Sousa

Costa

et al. 2019

Sci. Plena

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“…The extraction process may facilitate release of chemical components or active principles not released when the in natura plant is subjected to the digestion process (Coêlho et al, 2017). Toxicity and lethality tests are designed to measure the relative toxicity of substances and prevent undesirable effects in biological systems when the plants are used therapeutically (Forbes and Forbes, 1994;Silva et al, 2016). Despite the importance of this procedure, only 18% and 8% of the studies described in this review evaluated toxicity and lethality effects, respectively.…”

Section: Forms Of Plants For Use As Anthelminticsmentioning

confidence: 99%

Efficacy, toxicity, and lethality of plants with potential anthelmintic activity in small ruminants in Brazil

Mottin

Cruz

Neto

et al. 2019

Rev. bras. saúde prod. anim.

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SUMMARY The use of medicinal plants as a therapeutic method in the control of diseases has been increasing in animal production. In the case of small ruminants, the endoparasitic disease is a major concern, since they are considered the greater sanitary problem, especially when considering the phenomenon of parasite resistance to the medicines used. Therefore, the development of alternative methods of endoparasitary control in goats and sheep has become a pressing need. The use of plants to control endoparasites can reduce the use of chemical inputs, making more environmentally sustainable livestock, minimizing the occurrence of parasitic resistance to conventional medicines and contributing to the reduction of production costs. In this sense, several studies have been carried out in order to evaluate the in vitro and in vivo activity of plants with anthelmintic potential. However, despite the potentiality found in many studies, the results are sometimes contradictory or do not replicate in vivo the same efficacy obtained in the in vitro assays. Another relevant aspect is the low utilization of the lethality and toxicity tests, which are indispensable so that the knowledge can be spread and applied by the producers in their herds. Thus, this review aims to provide the results from studies carried out in Brazil with extract of plants with potential for control of parasitic disease in goats and sheep, describing the main evaluated plants species, mechanisms of action, preparation forms and tests of efficacy, toxicity, and lethality.

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“…Numerous plants used in folk medicine as "antidiarrheal" contain chemical substances that aid in the control of diarrhea associated with increased secretion and intestinal motility due to their astringent, antimicrobial or antiparasitic actions. [1][2][3] Inhibition of bacterial growth by a plant extract may be related to the action of secondary metabolites or a group of active compounds, the phytocomplex, present in the plant, which may be responsible for the biological effects of a medicinal plant. 4 The genus Pouteria (Sapotaceae family) has as its main constituents the triterpenoids and flavonoids 5 , and such compounds have proven antiinflammatory, antiviral, analgesic, cardiovascular, antitumor and anti-HIV 6 activity, and are also active against gram-positive and gram-negative bacteria, and fungi.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antidiarrheal Activities of Methanolic Fruit Peel Extract of Pouteria caimito

Mm¹,

A²,

Pf³

et al. 2019

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Introduction: Pouteria caimito is a native Amazonian fruit specie, popularly known as "abiu", that belongs to the Sapotaceae family. It has a wide popular use to relieve diarrhea, cough, fever and inflammation, among other purposes. However, few reports in the scientific literature deal with its phytochemical composition and biological activity. This study aimed to evaluate the antidiarrheal and antimicrobial activity of Pouteria caimito fruit peel extract. Methods: The antidiarrheal activity was evaluated in mice, using modulation models of normal defecation, cathartic agent-induced diarrhea and stimulated intestinal transit. Antimicrobial activity was, in turn, analyzed against strains of gram-positive and gram-negative bacteria (E. coli, S. epidermidis, S. aureus, Klebsiella pneumonie, E. faecalis and Salmonella tiphy) through the determination of the minimum inhibitory concentration (MIC) by the microdilution in broth method. Results: This study showed that there was no antidiarrheal activity in the experimental models analyzed and that the methanolic extract of P. caimito (MEPC) can positively modulate normal defecation. Regarding the antimicrobial activity, the crude extract and the ethyl acetate fraction presented a satisfactory action against most of the strains evaluated except for Enterococcus faecalis and Salmonella tiphy. Conclusions: The MEPC did not present any measurable antidiarrheal activity, but more possibly a laxative effect. The extract and acetate fraction showed antimicrobial activity against strains of gram-positive and gram-negative bacteria. The activity of the crude extract was more potent than the results obtained by the use of acetate fractions; the fractions with lower polarity did not present any relevant antimicrobial activity.

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Avaliação da toxicidade aguda pré-clínica do extrato metanólico das cascas do caule de Parahancornia amapa (Apocynaceae)

Cited by 10 publications

References 15 publications

Etnobotânica de Parahancornia fasciculata (Apocynaceae): extração, usos e comercialização do leite de amapá na comunidade da ilha Trambioca, Barcarena, Pará, Brasil

Etnobotânica de Parahancornia fasciculata (Apocynaceae): extração, usos e comercialização do leite de amapá na comunidade da ilha Trambioca, Barcarena, Pará, Brasil

Efficacy, toxicity, and lethality of plants with potential anthelmintic activity in small ruminants in Brazil

Antimicrobial and Antidiarrheal Activities of Methanolic Fruit Peel Extract of Pouteria caimito

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