Abstract:(Hansen et al,, 1982), além do custo maior decorrente do processo de purificação.Por outro lado, as sul fon i 1uréi as, drogas que agem preferencialmente liberando insulina (Houssay et al., 1957), têm efeitos terapêuticos limitados, alem de produzirem um nüme-ro considerável de efeitos colaterais (Larner, 1980).
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