Avaliação da atividade moluscicida de extratos vegetais. II

Lopes, João Luís Callegari; Lopes, José Fernando Scarelli; Souza, Cecília Pereira de; Cunha, Wilson Roberto

doi:10.1590/1809-43921988185149

Acta Amaz.

1988

DOI: 10.1590/1809-43921988185149

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Avaliação da atividade moluscicida de extratos vegetais. II

João Luís Callegari Lopes¹,

José Fernando Scarelli Lopes²,

Cecília Pereira de Souza

et al.

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Cited by 2 publications

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“…Biological studies with Brazilian species have demonstrated the high potential of Asteraceae, mainly in controlling great endemies [4–7]. Chemically, the special characteristic of Asteraceae is to produce and to accumulate sesquiterpene lactones (STL) [6,8].…”

mentioning

confidence: 99%

Neuropharmacological Effects in Mice of Lychnophora Species (Vernonieae, Asteraceae) and Anticonvulsant Activity of 4,5‐di‐O‐[E]‐caffeoylquinic Acid Isolated From the Stem of L. rupestris and L. staavioides

Contini

Santos

Mortari

et al. 2008

Basic Clin Pharma Tox

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Aiming at contributing with the search for neuroactive substances from natural sources, we report for the first time antinociceptive and anticonvulsant effects of some Lychnophora species. We verify the protective effects of polar extracts (600 mg/kg, intraperitoneally), and methanolic fractions of L. staavioides and L. rupestris (100 mg/kg, intraperitoneally) in pentylenetetrazole-induced seizures on mice. Previously, a screening was accomplished, evaluating the antinociceptive central activity ( hot plate test), with different extracts of L. rupestris , L. staavioides and L. diamantinana . It was possible to select the possible extracts of Lychnophora with central nervous system activity. Some of the active extracts were submitted to fractionation and purification process and the methanolic fractions of L. rupestris (stem) and L. staavioides (stem), with anticonvulsant properties (100 mg/kg, intraperitoneally), yielded 4,5-di-O-[E]-caffeoylquinic acid. This substance was injected intraperitoneally in mice and showed anticonvulsant effect against pentylenetetrazole-induced seizures at doses of 25 and 50 mg/kg. It has often been shown that seizures induced by pentylenetetrazole are involved in inhibition and/or attenuation of GABAergic neurotransmission. However, other systems of the central nervous system such as adenosinergic and glutamatergic could be involved in the caffeoylquinic acid effects. Further studies should be conducted to verify that the target receptor could be participating in this anticonvulsant property. Although other investigations have reported a series of biological activities from Lychnophora species, this is the first report of central analgesic and anticonvulsant activity in species of this genus.

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mentioning

confidence: 99%

Neuropharmacological Effects in Mice of Lychnophora Species (Vernonieae, Asteraceae) and Anticonvulsant Activity of 4,5‐di‐O‐[E]‐caffeoylquinic Acid Isolated From the Stem of L. rupestris and L. staavioides

Contini

Santos

Mortari

et al. 2008

Basic Clin Pharma Tox

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O uso da casca da castanha do caju, Anacardium occidentale, como moluscicida alternativo

Souza

Mendes

Jannotti-Passos

et al. 1992

Rev. Inst. Med. trop. S. Paulo

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Bioensaios usando extratos hexânicos de cascas da castanha do caju, Anacardium occidentale, coletadas no Ceará em 1972 (amostra 1) e em 1987 (amostra 2) foram feitos sobre moluscos adultos e desovas de Biomphalaria glabrata, B. tenagophila e B. straminea, no laboratório e no campo. As cascas, 18,5 g, sem triturar amostra 1, também foram testadas sobre moluscos adultos e desovas das três espécies. A toxidez do extrato foi testada ainda sobre peixes (Poecilia reticulata) e girinos. As concentrações letais CL90, amostra 1, foram de 2,0 a 2,2 ppm para os moluscos das três espécies. Para B. glabrata adultos, recém-eclodidos e desovas as CL90, amostra 2, foram de 2,0, 0,5 e 30,0 ppm respectivamente. As cascas causaram mortalidade de 40 a 80% dos moluscos e de 22 a 35% dos embriões, ocasionando redução de 40 a 55% na oviposição das três espécies. O extrato hexânico, amostra 2, foi inócuo para girinos e peixes até 2 ppm. No campo, em poços com água parada, tratados com 20 ppm do extrato, amostra 1, ocorreu 97,1% de mortalidade de B. straminea e 100% de B. glabrata e B. tenagophila. Com a niclosamida a 3 ppm ocorreu 100% de mortalidade das três espécies.

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Avaliação da atividade moluscicida de extratos vegetais. II

Cited by 2 publications

References 0 publications

Neuropharmacological Effects in Mice of Lychnophora Species (Vernonieae, Asteraceae) and Anticonvulsant Activity of 4,5‐di‐O‐[E]‐caffeoylquinic Acid Isolated From the Stem of L. rupestris and L. staavioides

Neuropharmacological Effects in Mice of Lychnophora Species (Vernonieae, Asteraceae) and Anticonvulsant Activity of 4,5‐di‐O‐[E]‐caffeoylquinic Acid Isolated From the Stem of L. rupestris and L. staavioides

O uso da casca da castanha do caju, Anacardium occidentale, como moluscicida alternativo

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