Atividade De Quitosanas Com Diferentes Pesos Moleculares Sobre Alternaria Solani

Coqueiro, Danila Souza Oliveira; Piero, Robson Marcelo Di

doi:10.1590/1808-1657v78p4592011

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…It is believed that chitosan's cationic nature and high molecular mass helps in its antifungal action, since it interferes with negatively charged residues of macromolecules on the fungal cell surface, thus causing changes in cell membrane permeability [17,18]. It can also prevent DNA transcription to RNA [15].…”

Section: Discussionmentioning

confidence: 99%

Application of Chitosan in the Control of Fungal Infections by Dermatophytes

Lopes¹,

Tavaria²,

Pintado³

2017

Ann Appl Microbiol Biotechnol J

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Dermatophytes are a group of fungi that can invade keratinized tissues of humans and other animals and produce an infection called Dermatophytosis. As chitosan possesses antimicrobial activity, it can potentially be used to treat dermatophytic infections. The main objective of this work was therefore, to evaluate the antifungal activity of chitosan upon some dermatophytes, namely Microsporum canis and Trychophyton rubrum. In view of this, Minimum Inhibitory (MICs) and Minimum Fungicidal Concentrations (MFCs) of chitosans upon the fungi were determined. Moreover, in order to understand the effect of chitosan on fungal activity, hair was infected with these fungi in the presence and absence of chitosan and Scanning Electron Microscopy (SEM) images were obtained and analyzed. Lastly, keratin-azure was used as substrate to evaluate the effect of chitosan on keratin degradation by M. canis and T. rubrum. The results showed that chitosan possesses antifungal activity against T. rubrum and M. canis, presenting MICs and MFCs ranging from 1.1 to 2.2 mg/mL. The antifungal activity of chitosan is concentration dependent. The analysis of SEM images of hair infected with these dermatophytes revealed that chitosan seems to have a protective effect on the hair, reducing the extent of damage when compared to the control. Chitosan also displayed important activity in preventing proteases' action and in preventing hair damage. Based on the obtained results, it's possible to conclude that chitosan showed relevant antifungal activity against dermatophytes, which opens good prospects to the use of chitosan as an alternative for the conventional fungal treatments.

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Section: Discussionmentioning

confidence: 99%

Application of Chitosan in the Control of Fungal Infections by Dermatophytes

Lopes¹,

Tavaria²,

Pintado³

2017

Ann Appl Microbiol Biotechnol J

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“…70 Mechanisms of action of chitosan: It is believed that chitosan's cationic nature and high molecular weight helps in its antifungal action, since it interferes with negatively charged residues of macromolecules on the fungal cell surface, thus causing changes in cell membrane permeability. 71,72 It can also prevent DNA transcription to RNA 73 and inhibit the RNA and protein synthesis by permeation into the cell nucleus. 68 Some authors 73 mentioned that antifungal activity of chitosan is molecular weight dependent and that the smaller the molecular weight is, the stronger the antifungal activity.…”

Section: Chitosanmentioning

confidence: 99%

Conventional and natural compounds for the treatment of dermatophytosis

2019

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Dermatophytes are a group of pathogenic fungi that exclusively infect the stratum corneum of the skin, nails, and hair, causing dermatophytosis. Superficial skin infections caused by dermatophytes have increased in the last decades. There are conventional antifungals that treat these infections, such as terbinafine, fluconazole, and others. However, the limitations of these treatments (resistance, side effects and toxicity) along with the increasing over-prescription, the misuse of these antifungals and the high treatment costs led to the search for new, alternative, natural-based antifungal drugs. These have multiple mechanisms of action, which works to their advantage, making it difficult for a fungus to create resistance mechanisms against all of them at the same time. The main objective of this work is to provide a state-of-the-art review on dermatophytes, dermatophytosis, and the existing treatments, both conventional and natural, such as chitosan and essential oils.

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