“…Due to the limited access to updated databases at the time of the project, this work stands as a proof-of-concept study demonstrating that matrix-compatible SPME devices with porous extraction phases are a viable option for peptide and protein analysis. The logistics of personal protective equipment (PPE) for frontline healthcare professionals has improved drastically since the pandemic, , enabling significant improvements to the reproducibility and reliability of sample collection under clinical settings. Variabilities accrued during the self-collection, transportation, storage, and treatment of biofluids can, therefore, be greatly reduced in future studies.…”