Synchronous jawbone diseases: a multicenter retrospective study

Abstract

The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type. Seventy-two synchronous jawbone diseases were included in this study. Florid osseous dysplasia, Gorlin-Goltz syndrome, and cherubism were the most frequent disorders reported in this case series. In addition, the posterior mandible area was the main site of manifestation. Florid osseous dysplasia and Gorlin-Goltz syndrome represented two-thirds of our samples. With the utilization of adequate demographic, clinical, and radiologic information, it is possible to diagnose most of the synchronous lesions of jawbones. Sometimes, however, we need complementary exams, such as histopathologic and biochemical analysis or dosing of calcium, phosphorus, and alkaline phosphatase.

Nonfamilial cherubism in a 6-month-old infant: a case report

“…Cherubism (OMIM #118,400) is classified by the World Health Organization (WHO) as a non-neoplastic bone lesion that exclusively affects the jaws [ 11 ] followed by an autosomal dominant mutation pattern with variable expressions of a gene on chromosome 4 that encodes SH3-domain binding protein 2, also known as SH3BP2 [ 4 ]. 20% of patients might not have this recognizable gene mutation pattern [ 12 ] and according to Rezende et al, male children are more prone to this mutation [ 13 ].…”

“…Regarding laboratory test findings, while most biochemical markers have been reported to be typically within a normal range, alkaline phosphatase, TNF-α urine calcium/creatinine, and other bone remodeling markers might be elevated [ 4 , 13 , 20 ]. Similarly, in our case, except for an elevated LDH and PLT, other laboratory findings were in the normal range.…”