Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis

Zamai, Rodrigo Soler; Corrêa, Mônica Grazieli; Ribeiro, Fernanda Vieira; Cirano, Fabiano Ribeiro; Casati, Márcio Zaffalon; Messora, Michel Reis; Pimentel, Suzana Peres

doi:10.1590/1807-3107bor-2023.vol37.0003

Cited by 3 publications

(1 citation statement)

References 41 publications

(79 reference statements)

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“…Micro-CT data were analyzed using CTAn 1.20 (Bruker), a high-resolution microscopic CT quantitative analysis software [ 26 , 27 ]. Orthodontic tooth movement was calculated by measuring the distance between the protruding point of the first molar distal wall and the second molar mesial wall.…”

Section: Methodsmentioning

confidence: 99%

Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy

Sun

Zhao

et al. 2023

Bioengineering

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Strontium ranelate (SR) is a pharmaceutical agent used for the prevention and treatment of osteoporosis and fragility fracture. However, little attention has been paid to the effect of SR on alveolar bone remodeling during orthodontic tooth movement and its underlying mechanism. Here, we investigated the influence of SR on orthodontic tooth movement and tooth resorption in Sprague–Dawley rats and the relationship between the nuclear factor–kappa B (NF-κB) pathway, autophagy, and osteoclastogenesis after the administration of SR in vitro and in vivo. In this study, it was found that SR reduced the expression of autophagy-related proteins at the pressure side of the first molars during orthodontic tooth movement. Similarly, the expression of these autophagy-related proteins and the size and number of autophagosomes were downregulated by SR in vitro. The results also showed that SR reduced the number of osteoclasts and suppressed orthodontic tooth movement and root resorption in rats, which could be partially restored using rapamycin, an autophagy inducer. Autophagy was attenuated after pre-osteoclasts were treated with Bay 11-7082, an NF-κB pathway inhibitor, while SR reduced the expression of the proteins central to the NF-κB pathway. Collectively, this study revealed that SR might suppress osteoclastogenesis through NF-κB-pathway-dependent autophagy, resulting in the inhibition of orthodontic tooth movement and root resorption in rats, which might offer a new insight into the treatment of malocclusion and bone metabolic diseases.

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Section: Methodsmentioning

confidence: 99%

Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy

Sun

Zhao

et al. 2023

Bioengineering

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The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

An,

Luo,

et al. 2024

J Orthop Surg Res

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Background There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. Methods The PubMed, Cochrane Library, Web of Science and Embase databases were searched up to August 2023. The risk of bias was assessed by the SYRCLE RoB tool. Random- or fixed-effects models were used to determine the 90% confidence interval (CI) or standardized mean difference (SMD). Statistical analysis was performed with RevMan 5.4 and Stata 14.0. Results A total of 24 studies containing 714 individuals were included. Compared with those in the control group, the bone mineral density (BMD) (P < 0.00001), bone volume/total volume (BV/TV) (P < 0.001), trabecular thickness (Tb.Th) (P < 0.00001), and trabecular number (Tb.N) (P < 0.00001) were markedly greater, and the trabecular separation (Tb.Sp) (P < 0.00001) was significantly greater. Compared with the control group, the Res group also exhibited marked decreases in alkaline phosphatase (ALP) (P < 0.05), tartrate-resistant acid phosphatase 5b (TRAP5b) (P < 0.01), and type I collagen strong carboxyl peptide (CTX-1) (P < 0.00001) and a marked increase in osteoprotegerin (OPG) (P < 0.00001). Conclusion In summary, we concluded that Res can markedly increase BMD, improve morphometric indices of trabecular microstructure and serum bone turnover markers (BTMs), and exert a protective effect in animal models of primary osteoporosis. This study can supply experimental reference for Res in primary osteoporosis treatment.

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Evaluating the Efficacy of Transresveratrol in Extraction Socket of Impacted Mandibular Third Molar: A Double-blind Study

Prathigudupu,

Gavarraju,

Gunti

et al. 2023

World Journal of Dentistry

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Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis

Cited by 3 publications

References 41 publications

Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy

Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

Evaluating the Efficacy of Transresveratrol in Extraction Socket of Impacted Mandibular Third Molar: A Double-blind Study

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