Expression of inflammatory mediators in periodontitis and T2D patients: a systematic review and meta-analysis

Mattos, Mariana Caldas de Oliveira; Chagas, Laís Garreto Alves de Almeida; Stefani, Cristine Miron; Damé‐Teixeira, Nailê; Grisi, Daniela Corrêa; Salles, Loise Pedrosa; Oliveira, Laudimar Alves de; Carneiro, Valéria Martins de Araújo; Guimarães, Maria do Carmo Machado

doi:10.1590/1807-3107bor-2022.vol36.0098

Cited by 1 publication

(1 citation statement)

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“…Poor glycemic control leads to the deterioration of periodontal health and the promotion of periodontal disease as a risk factor for diabetes, while diabetes increases the prevalence and severity of gingivitis and periodontitis. Developed studies have concluded that periodontal treatment can improve glycemic control by restricting inflammation, probably by improving insulin sensitivity [7,8]. Moreover, patients with DM2 and periodontitis show elevated levels of interleukin (IL)-10, while the concentration of IL-4 in diabetic subjects with periodontitis is low compared to non-diabetic patients with periodontitis, showing that there is a correlation between the level of these markers and the impairment of the immune response of patients with periodontitis and DM2.…”

Section: Two-way Relationship Between Type 2 Diabetes and Periodontitismentioning

confidence: 99%

Oral Health Education in Patients with Diabetes: A Systematic Review

Petropoulou,

Kalemikerakis,

Dokoutsidou

et al. 2024

Healthcare

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Diabetes is known as a “silent epidemic” and is a public health problem that accounts for 9% of all deaths worldwide. The prevention of diabetes is a significant challenge, as its prevalence and incidence are both increasing rapidly. According to the World Health Organization (WHO), education is the cornerstone of diabetes treatment. Since the severity of oral diseases is significantly higher in diabetic patients, this systematic review aims to highlight the oral care of diabetic patients as a priority for glycemic control and the importance of education for diabetic patients’ oral health. We evaluated 20 clinical studies and 15 meta-analyses from PubMed and Google Scholar over the last five years. Their main themes are the direct relationship between diabetes and oral health, especially periodontitis, and the necessity of education and behaviors that can lead to a better quality of life. Our analysis indicated that good oral health is a critical factor of glycemic control in diabetic patients and can be enhanced by targeted educational programs, backed by long-term medical and dental follow-up. Healthcare personnel should be encouraged to develop their knowledge of oral health in relation to the disease so that behaviors can be adopted to improve patients’ quality of life. Telemedicine could also contribute to patient education and self-management of the disease.

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Section: Two-way Relationship Between Type 2 Diabetes and Periodontitismentioning

confidence: 99%