Effect of different factors on patient perception of surgical discomfort in third molar surgery

Reis, Giselle Emilãine da Silva; Calixto, Robson Diego; Petinati, Maria Fernanda Pivetta; Souza, Juliana Feltrin de; Küchler, Érika Calvano; Costa, Delson João da; Bonotto, Daniel; Rebellato, Nelson Luís Barbosa; Scariot, Rafaela

doi:10.1590/1807-3107bor-2021.vol35.0007

Cited by 5 publications

(1 citation statement)

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“…The product encoded by FKBP5 affects glucocorticoid receptor sensitivity and the biological effects of stress and anxiety [ 19 ]. Polymorphic variants in FKBP5 have been associated with a greater risk of depression [ 24 , 25 ], anxiety [ 25 ] and post-traumatic stress disorder [ 24 ] as well as greater surgical discomfort in third molar extractions [ 54 ]. Although we did not find an association between HTR2A and FKBP5 with anxiety, depression and chronic pain in this study, it is important to remember that we evaluated only two polymorphisms within the genes, so it is possible that there are associations in other polymorphisms in these genes with mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Baldiotti

Amaral-Freitas

Barbosa

et al. 2023

IJERPH

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Adolescence is marked by changes and vulnerability to the emergence of psychological problems. This study aimed to investigate associations between anxiety/depression/chronic pain and oral health-related quality of life (OHRQoL)/happiness/polymorphisms in the COMT, HTR2A and FKBP5 genes in Brazilian adolescents. A cross-sectional study was conducted with ninety adolescents 13 to 18 years. Anxiety, depression and chronic pain were evaluated using the RDC/TMD. The Oral Health Impact Profile was used to assess oral OHRQoL. The Subjective Happiness Scale was used to assess happiness. Single-nucleotide polymorphisms in COMT (rs165656, rs174675), HTR2A (rs6313, rs4941573) and FKBP5 (rs1360780, rs3800373) were genotyped using the Taqman® method. Bivariate and multivariate logistic regression analyses were performed (p < 0.05). Chronic pain and depression were associated with feelings of happiness (p < 0.05). A significant inverse association was found between anxiety and OHRQoL (p = 0.004). The presence of minor allele C of COMT rs174675 was significantly associated with depression (p = 0.040). Brazilian adolescents with depression and chronic pain considers themselves to be less happy than others and those with anxiety are more likely to have a negative impact on OHRQoL. Moreover, the rs174675 variant allele in the COMT gene was associated with depressive symptoms in Brazilian adolescents.

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