DEC1: a potential biomarker of malignant transformation in oral leukoplakia

Mao, Ting; Xiong, Haofeng; Hu, Xin; Hu, Yue; Wang, Can; Yang, Luting; Huang, Danni; Xia, Kun; Su, Tian

doi:10.1590/1807-3107bor-2020.vol34.0052

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…In our previous studies, DEC1 had been initially confirmed involving in the development and prognosis of OSCC, 10 and could promote OSCC cells migration induced by hypoxia‐inducible factor‐1α 11 . Moreover, our study in oral leukoplakia (OLK) supported that DEC1 may play important role in the malignant transformation of oral mucosa 12 . However, the mechanism of DEC1 in the progression of OSF and whether DEC1 is involved in the malignant transformation of OSF remain unknown.…”

Section: Introductionsupporting

confidence: 60%

“…11 Moreover, our study in oral leukoplakia (OLK) supported that DEC1 may play important role in the malignant transformation of oral mucosa. 12 However, the mechanism of DEC1 in the progression of OSF and whether DEC1 is involved in the malignant transformation of OSF remain unknown. Therefore, we speculate that studying DEC1 in OSF may help us understand the mechanism of OSF carcinogenesis.…”

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confidence: 99%

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Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

Wang

et al. 2022

J Oral Pathology Medicine

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Background: Previous studies on oral submucous fibrosis (OSF) mostly focused on the activation of fibroblasts and collagen metabolism, while little involved in the epithelium. As we have reported the role of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in oral cancer and other precancerous lesions, this research aimed to explore its role in the OSF epithelium.Methods: Expression of DEC1 and other proteins were investigated in tissue array constructed with 33 OSF and 14 normal oral mucosa (NOM) tissues. Human oral keratinocytes treated with arecoline and/or hypoxia were used to simulate OSF epithelium and detected for morphological and protein alterations. Inhibition of DEC1 was used to explore its mediating role. Finally, animal models of OSF constructed by locally arecoline injecting in buccal mucosa were used to verify our findings.Results: DEC1 overexpression could be detected in the epithelium of OSF compared with that in NOM followed by phosphorylated FAK and Akt, and DEC1 showed a significant positive correlation with them. Cytology experiment revealed that OSF-like treatment could upregulate DEC1 expression followed by phosphorylated FAK, Akt, but inhibit E-cadherin, while knockdown of DEC1 could suppress the effects. In addition, OSF mice revealed higher expression of DEC1 in the epithelium of buccal mucosa, along with synchronized alterations of phosphorylated FAK and Akt. Conclusion: In the epithelium of OSF, overexpression of DEC1 induced activation of FAK/Akt signal axis, caused mesenchymal transition in epithelial cells, and may promote malignant transformation of OSF. Targeting DEC1 in OSF could be promising a new target for the diagnosis and treatment of this process. K E Y W O R D S arecoline, differentiated embryo-chondrocyte expressed gene 1, focal adhesion kinase, malignant, oral submucous fibrosis 1 | INTRODUCTION Oral submucous fibrosis (OSF) is a chronic mucosal disease that mainly occurs in the buccal and gingival areas of the oral mucosa, and has attracted attention due to causing progressive restriction of Xin Hu and Weiming Wang contributed equally to this study and should be identified as cofirst authors.

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Section: Introductionsupporting

confidence: 60%

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confidence: 99%

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

Wang

et al. 2022

J Oral Pathology Medicine

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“…3 C–I) [23 , 24] . Likewise, the expression of survivin, a major antiapoptotic protein [14] , is significantly higher in DEC1 +/+ than DEC1 −/− CRC mice ( Fig. 3 C, F).…”

Section: Discussionmentioning

confidence: 86%

“…Differentiated embryonic chondrocyte expressed gene 1 (DEC1, BHLHE40) belongs to the superfamily of the basic helix-loop-helix (bHLH) transcription factors [13] . This transcription factor has a broad tissue distribution and is involved in diverse cellular events such as differentiation, proliferation and apoptosis [14] . Physiologically, DEC1 is a clock gene and regulates circadian rhythmicity and metabolic functions [14 , 15] .…”

Section: Introductionmentioning

confidence: 99%

“…This transcription factor has a broad tissue distribution and is involved in diverse cellular events such as differentiation, proliferation and apoptosis [14] . Physiologically, DEC1 is a clock gene and regulates circadian rhythmicity and metabolic functions [14 , 15] . Pathologically, DEC1 expression is positively associated with tumor development and invasiveness in such malignancies as breast cancer [16] , gastric carcinomas [17] and colon cancer [18] .…”

Section: Introductionmentioning

confidence: 99%

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Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling

et al. 2022

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Oral verrucous leukoplakia progression to malignancy: a case report with review of literature

2022

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<p>Oral leukoplakia is one of most prevalent oral potential malignant disorders caused due to smoking. Non homogenous forms of leukoplakia have the higher rates of malignant transformation. Clinical diagnosis of these lesions is essential to avoid the fatality. Hereby, we report a case of verrucous leukoplakia which was histo-pathologically diagnosed as verrucous leukoplakia with moderate dysplasia and managed with surgical excision.</p>

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DEC1: a potential biomarker of malignant transformation in oral leukoplakia

Abstract: Haofeng XIONG (b) Xin HU (a) Yue HU (a) Can WANG (a) Liudi YANG (a) Danni HUANG (a) Kun XIA (b) Tong SU (a)

Cited by 8 publications

References 21 publications

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis

Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling

Oral verrucous leukoplakia progression to malignancy: a case report with review of literature

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