Abstract:The abnormal increase in proliferation rate of human periodontal ligament stem cells (PDLSCs) is considered to be involved in the pathogenesis of periodontitis, a disease in which the IL-10-mediated anti-inflammatory pathway plays a critical role. This study aimed to investigate the involvement of microRNA-466l in periodontitis and to explore the possible interaction between IL-10 and microRNA-466l. PDLSCs were obtained from periodontitis-affected teeth and healthy control teeth. The expression of microRNA-466… Show more
“…In periodontitis, IL-10 levels can deregulate the synthesis of pro-inflammatory cytokines. 34 IL-10 is an anti-inflammatory mediator, and the main regulator of inflammatory responses; it plays an important role in the pathogenesis of periodontitis. 35 IL-10 levels in patients with periodontitis tend to be lower in comparison with those of healthy patients, and this decrease may cause greater susceptibility of the individual in developing chronic periodontitis.…”
“…In periodontitis, IL-10 levels can deregulate the synthesis of pro-inflammatory cytokines. 34 IL-10 is an anti-inflammatory mediator, and the main regulator of inflammatory responses; it plays an important role in the pathogenesis of periodontitis. 35 IL-10 levels in patients with periodontitis tend to be lower in comparison with those of healthy patients, and this decrease may cause greater susceptibility of the individual in developing chronic periodontitis.…”
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