Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease

Toledo, André Oliveira Naufel de; Couto, Aline Maria do; Madeira, Mila Fernandes Moreira; Caldeira, Patrícia Carlos; Queiroz-Junior, Celso Martins; Aguiar, Maria Cássia Ferreira de

doi:10.1590/1807-3107bor-2019.vol33.0093

Cited by 12 publications

(10 citation statements)

References 37 publications

(55 reference statements)

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“…The functions of the T lymphocyte family, including Th1, Th2, Th17, and regulatory T (Treg) cells, have been extensively described. Recent studies have focused on Th17 and Treg cells, which have opposite roles in the immune response in periapical lesions (Toledo et al, 2019). Treg and Th17 cells are thought to be important junctions between the immune system and bone (Zhang et al, 2021).…”

Section: T Cellsmentioning

confidence: 99%

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Xu-tao

Wan

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Chronic periapical periodontitis (CAP) is a typical oral disease in which periodontal inflammation caused by an odontogenic infection eventually leads to bone loss. Uncontrolled infections often lead to extensive bone loss around the root tip, which ultimately leads to tooth loss. The main clinical issue in the treatment of periapical periodontitis is the repair of jawbone defects, and infection control is the first priority. However, the oral cavity is an open environment, and the distribution of microorganisms through the mouth in jawbone defects is inevitable. The subversion of host cell metabolism by oral microorganisms initiates disease. The presence of microorganisms stimulates a series of immune responses, which in turn stimulates bone healing. Given the above background, we intended to examine the paradoxes and connections between microorganisms and jaw defect repair in anticipation of new ideas for jaw defect repair. To this end, we reviewed the microbial factors, human signaling pathways, immune cells, and cytokines involved in the development of CAP, as well as concentrated growth factor (CGF) and stem cells in bone defect repair, with the aim of understanding the impact of microbial factors on host cell metabolism to inform the etiology and clinical management of CAP.

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Section: T Cellsmentioning

confidence: 99%

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Xu-tao

Wan

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Studies showed the importance of cytokines in pulp and periapical diseases (23,24). One of the most important cytokines involved in the pulp and periapical inflammatory response is IL-1β (24,25). This cytokine is secreted from a wide variety of cells (24).…”

Section: Resultsmentioning

confidence: 99%

Comparison of curative effect between different retrograde filling materials in young permanent molar root canal therapy

Zhang

Zheng

2022

Cell Mol Biol (Noisy-le-grand)

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The first mandible and maxilla permanent molars are the first permanent teeth that grow next to the deciduous teeth and may decay due to carelessness. Their caries can spread to the pulpal tentacles and cause pulpal and periapical diseases. In the current study, we tried to compare the curative effect of different retrograde filling materials, i.e. white MTA, gray MTA, Portland cement, and IRM, in young permanent molar root canal therapy. Because IL-1β stimulates bone degradation by osteoclasts, IL-1β gene expression was also measured for further evaluation. For this purpose, 400 students (240 boys and 160 girls) aged 8 to 11 years referred to the Pediatric Dental Center for first permanent molar root canal therapy were selected during two years. After recording the demographic characteristics of each patient, the first permanent molar teeth were examined by a general dentist with Abslang and decayed teeth were considered to have both discolorations in their grooves and apparent opacity. The patients, who need root canal therapy, were divided into four groups. The first group was treated with gray MTA. The second group was treated with white MTA. The third group received Portland cement for root canal therapy. The fourth group was treated with IRM. Also, IL-1β gene expression was evaluated by the real-time PCR technique. Relative changes in gene expression in PBMC cells were performed using One Way ANOVA. SPSS 18 software was used to determine the correlation of gene expression in PBMCs. The results showed that there was no significant difference between the groups in terms of age (p = 0.12) and gender (p = 0.24). Also, the need for endodontic treatment in the mandible (n = 278) was higher than the maxilla (n = 85) and both jaws (n = 37). But there was no significant difference between the groups in terms of the need for endodontic treatment (p = 0.32). The results of Pearson correlation coefficients between studied groups in terms of IL-1β gene expression showed that gray MTA and white MTA were not statistically different, but MTAs were generally different from Portland cement and IRM, with higher IL-1β gene expression. In general, the results showed that the teeth in the vicinity of gray MTA and white MTA showed a more appropriate response than Portland cement and IRM, so the use of MTA and its preference over other materials is recommended. In the case of Portland cement, more studies are needed to reach a conclusion comparing this material with MTA.

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“…An analysis of chemokines in the necrotic pulp tissue did not show any difference in comparison with healthy tissues (41). Otherwise, another study reported higher levels of CCL4 in the AP lesion when compared with the controls (42). In our study, the variations of CCL3 and CCL4 contents in serum did not appear to correlate with T2DM and AP.…”

Section: Discussionmentioning

confidence: 95%

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

et al. 2021

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This pilot study assessed the glycaemic control and the serum levels of inflammatory mediators in type 2 diabetes (T2DM) patients with apical periodontitis (AP). Thirty individuals were divided into four groups: Healthy (H); with AP (AP); with T2DM (T2DM); and with T2DM and AP (T2DM-AP). Demographic and pharmacological data were registered. The body mass index (BMI) and the levels of glycated haemoglobin (HbA1c) and IL-1b, IL-6, IL-10, CCL3 and CCL4 were evaluated. AP areas were determined radiographically. Mean age was 64 AE 12 years, with 63% females. Most T2DM patients were under treatment with metformin and antihypertensives. BMI and H1bAc were significantly higher in T2DM patients in relation to H and AP groups. The AP areas were larger in the T2DM-AP group, compared with the AP group. These preliminary findings suggest no influence of AP on glycaemic control or inflammatory levels amongst T2DM patients, although T2DM increased the AP severity.

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Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease

Cited by 12 publications

References 37 publications

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Comparison of curative effect between different retrograde filling materials in young permanent molar root canal therapy

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

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