A comparison of different bone graft materials in peri-implant guided bone regeneration

Artaş, Gökhan; Gul, Mehmet; Acıkan, İzzet; Kırtay, Mustafa; Bozoğlan, Alihan; Simsek, Serkan; Yaman, Ferhan; Dündar, Serkan

doi:10.1590/1807-3107bor-2018.vol32.0059

Cited by 21 publications

(23 citation statements)

References 27 publications

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“…In the present study, the staining intensity of TG2 and VEGF, commonly accepted as markers for angiogenesis (Buemi et al., 2004), were comparable between the test and positive control groups at 8 and 16 weeks. These result are in agreement with previous studies also not reporting difference in VEGF expression when different bone substitutes were evaluated during the healing of peri‐implant defects in rats at 3 months (Artas et al., 2018). When evaluating the angiogenesis at the level of the barrier membrane, the pattern of transmembranous angiogenesis based on the VEGF and TG2 positive cells were different between the cross‐linked and non‐crosslinked membrane groups, being delayed in the cross‐linked group.…”

Section: Discussionsupporting

confidence: 93%

Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects: An experimental in vivo study

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Vignoletti

et al. 2021

Clinical Oral Implants Res

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Aim To investigate the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross‐linked collagen membrane for guided bone regeneration. Methods Three experimental groups were randomly allocated at chronic peri‐implant dehiscence defect in 8 beagle dogs: (i) biphasic calcium phosphate covered by a cross‐linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control) and (iii) no treatment (negative control). After 8 and 16 weeks of submerged healing, dissected tissue blocks were processed for immunohistochemical analysis. Seven antibodies were used to detect the remaining osteogenic and angiogenic potential, and quantitative immunohistochemical analysis was done by software. Results The antigen reactivity of alkaline phosphatase was significantly higher in the test group compared to the positive and negative controls, and it maintained till 16 weeks. The intensity of osteocalcin was significantly higher in the positive control at 8 weeks than the other groups, but significantly decreased at 16 weeks and no difference was found between the groups. A significant large number of TRAP‐positive cells were observed in the test group mainly around the remaining particles at 16 weeks. The angiogenic potential was comparable between the groups showing no difference in the expression of transglutaminase II and vascular endothelial growth factor. Conclusion Guided bone regeneration combining a highly porous biphasic calcium phosphate synthetic biomaterial with a crosslinked collagen membrane, resulted in extended osteogenic potential when compared to the combination of deproteinized bovine bone mineral and a native collagen membrane.

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Section: Discussionsupporting

confidence: 93%

Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects: An experimental in vivo study

Kook

Plá

Vignoletti

et al. 2021

Clinical Oral Implants Res

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“…On the other hand, radiological and mechanical techniques have been used for structural and functional evaluations (50)(51)(52). Different bone graft materials are currently available for regeneration of bone defects in oral and maxillofacial surgery, such as the closure of osteotomy openings and alveolar increment (53)(54)(55)(56)(57). Synthetic bone graft materials are available in intra-bone defects, orthognathic surgery, facial bone defects, and maxillary sinus ground (54,(58)(59)(60)(61)(62)(63).…”

Section: Discussionmentioning

confidence: 99%

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

et al. 2020

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Background:The present study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage. Materials and methods:Wistar male rats (n = 56) were divided into four groups: a control group (n = 14), defect and ozone group (n = 14), defect and graft group (n = 14), and defect, graft, and ozone group (n = 14). Under anaesthesia, a circular full-thickness bone defect was created in all groups, and the experimental groups were further divided into two sub-groups, with seven rats in each group sacrificed at the end of the 4 th and 8 th weeks. Bone samples were dissected, fixed in 10% formalin solution, and decalcified with 5% ethylene-diaminetetraacetic acid (EDTA). After the routine follow-up on tissues, immunostaining of osteopontin and osteonectin antibodies was applied to sections and observed under a light microscope. Results:The control group exhibited osteopontin and osteonectin expression in fibroblasts and inflammatory cells at the end of the 4 th week with an acceleration at the 8 th week. Ozone administration elucidated new trabecular bone formation by increasing osteoblastic activity.Lastly, our observations underscore that a combination of allograft and ozone application increased the osteoblast, osteocyte, and bone matrix development at the 4 th and 8 th weeks. Conclusions:Exposure to an ozone application with an alloplastic bone graft on calvarial bone damage may induce osteoblastic activity, matrix development, mature bone cell formation, and new bone formation in rats.

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“…The necessity of having to harvest bone grafts is the major shortcoming of this procedure. Moreover, a possible risk of donor site morbidity and other adverse events in neighboring anatomical structures may be encountered [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study

et al. 2021

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The aim of this study was to evaluate the influence of additional hydroxyapatite (HA) in collagen-based matrices (CM) and membrane placement on bone formation in calvarial defects. Critical size defects in the calvaria of 16 New Zealand White Rabbits were randomly treated with CM or mineralized collagen-based matrices (mCM). Half of the sites were covered with a collagen membrane. Animals were euthanized after 12 weeks of healing. The samples were studied by micro-CT and histology. Newly formed lamellar bone was observed in all samples at the periphery of the defect. In the central areas, however, new bone composed of both woven and lamellar bone was embedded in the soft tissue. Samples treated with mCM showed more residual biomaterial and induced more small bony islands in the central areas of the defects than samples with CM. Nevertheless, a complete defect closure was not observed in any of the samples at 12 weeks. Membrane placement resulted in a decrease in bone density and height. Significant differences between the groups were revealed only between CM groups with and without membrane coverage for bone height in the central area of the defect. Neither mineralization of CM nor membrane placement improved the osteogenic capacity in this particular defect. Nevertheless, mineralisation influenced bone density without a membrane placement and bone volume underneath a membrane. CM may be used as a scaffold in bone regeneration procedures, without the need of a membrane coverage. Further preclinical studies are warrant to optimise the potential of mCM.

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A comparison of different bone graft materials in peri-implant guided bone regeneration

Cited by 21 publications

References 27 publications

Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects: An experimental in vivo study

Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects: An experimental in vivo study

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study

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