Effect of Topical Erythropoietin (EPO) on palatal wound healing subsequent to Free Gingival Grafting (FGG)

Abstract

Free gingival grafting, the most predictable technique to increase the keratinized gingiva, leaves an open wound on the palate and the resulting discomfort during the healing phase is a significant concern. This study was intended to evaluate the effect of topical erythropoietin on healing of the donor site. Twelve patients lacking an attached gingiva at two sites in the mandible were included. In the test group, 1 mL of gel containing erythropoietin at a concentration of 4,000 IU mL-1 was applied to the donor site, whereas the control group was treated with 2 mL of the gel alone. On the second day after surgery, the same procedure was repeated. H2O2 was used to evaluate the amount of epithelialization. Clinical healing was compared using photographs and direct examination. The EPO group showed significantly better keratinization only on day 21. Comparison of clinical healing based on direct examination revealed significantly better healing in the test group on day 28. Furthermore, inflammation in the test group was lower than in the control group on the same day. Topical application of EPO improves palatal wound healing during the third and fourth weeks after free gingival graft procedures.

Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial

“…Clinical trials have applied laser 8,9,37 and growth factors therapies, 39 with a wide variety of protocols, to accelerate wound healing after palatal graft harvest. Little or non‐difference was shown when RWA evaluation was performed after laser therapy on palatal wounds 8,9,37 .…”

“…reported that laser photobiomodulation improved tissue repair after FGG harvesting, re‐epithelialization rates presented a delay when compared with the present study. Yaghobee et al 39 . applied erythropoietin (EPO) on FGG donor sites.…”

Photobiomodulation- Yes or No?. following laser gingival depigmentation: A case report

“…Wound healing is a complex process comprising parallel overlapping events: the hemostatic phase leads to sealing of the wound by a clot formed by extravasated platelets and other blood-derived cells in a network composed of fibrin, fibronectin, and vitronectin. 8 Numerous animal models and human clinical studies have addressed the effects of PBM and their positive impact during the inflammation, proliferation, and remodeling phases for acceleration of reepithelialization. [9][10][11][12] Particularly, after PBM applications, TGF-b pathway has been reported to have a central role in mediating a diverse range of biological functions, such as inflammatory response, vascularization, extracellular matrix synthesis and deposition, and collagen expression.…”

Regenerative properties of recombinant human erythropoetin in wound healing

“…В РКИ S. Yaghobee, при пересадке лоскутов десны, после местного применения ЭПО отмечалось значительное улучшение эпителизации тканей [36].…”