The need for endodontic treatment and systemic characteristics of hematopoietic stem cell transplantation patients

Braga-Diniz, Julia Mourão; Santa-Rosa, Caroline Christine; Martins, Renata de Castro; Silva, Maria Elisa Souza e; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1590/1807-3107bor-2017.vol31.0050

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…However, the change was not significant. These findings are supported by a clinical study that reported an increased level of hemoglobin, platelet, and neutrophils in HSCT recipients after the BMT [20]. Another clinical study reported a fast recovery of platelet count and TLC post-HSCT compared to ANC after HSCT in cancer patients [21].…”

Section: Discussionmentioning

confidence: 60%

Short-Term Impact of Hematopoietic Stem Cell Transplantation in Leukemia Patients on Bone Bio Markers, Electrolytes and Blood Profile

Joshi¹,

Khan²,

Garg³

et al. 2023

OBM Transplant

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Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. However, the cure can only be achieved at the price of morbidity and long-term complications such as bone diseases leading to fractures and osteopenia. Several studies have reported the impact of organ transplants on bone metabolism, electrolytes and blood profile. This prospective observational clinical study aims at elucidating the effects of HSCT on bone metabolism, electrolytes and blood profile in leukemia patients. Sixty patients were included in this study. The current study aimed to evaluate the short-term (30 days) impact of HSCT on bone biomarkers [osteoprotegerin (OPG) and alkaline phosphatase], electrolytes (calcium, sodium, potassium, and magnesium), and blood profile [hemoglobin, absolute neutrophil count (ANC), platelet, and total leucocyte count (TLC)] in leukemia patients undergoing HSCT from their record files before HSCT (TP1) and after 30 days of HSCT (TP2). Further, the correlation among various parameters at TP2 was assessed using Spearman correlation analysis. At TP2, the level of OPG, alkaline phosphatase, calcium, magnesium and TLC increased significantly compared to TP1. However, no significant change was observed in other parameters at TP2 compared to TP1. A statistically significant positive correlation of TLC with hemoglobin and sodium; and magnesium with alkaline phosphatase was observed. Furthermore, a significant negative correlation between hemoglobin and calcium was observed. Even though there was a statistically significant increase in the level of OPG, alkaline phosphatase, calcium, magnesium and hemoglobin after 30 days of HSCT, the level of bone biomarkers, electrolytes and blood profile were in the normal physiological range. However, additional studies are required to get a detailed understanding of the changes in parameters after HSCT.

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Section: Discussionmentioning

confidence: 60%

Short-Term Impact of Hematopoietic Stem Cell Transplantation in Leukemia Patients on Bone Bio Markers, Electrolytes and Blood Profile

Joshi¹,

Khan²,

Garg³

et al. 2023

OBM Transplant

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“…Furthermore, two-dimensional imaging (PAN and periapical radiography) is commonly accepted as a method for the diagnosis of AP, while three-dimensional imaging (conebeam computed tomographic (CBCT)) represents a second evaluation step in some cases (26,27). Due to the immunosuppression status of these patients (28), inclusion and exclusion criteria were strictly applied and patients with other malign or hematological diseases were excluded, in order to reduce the effect of covariables. However, the lack of other studies evaluating the presence of AP lesions and endodontic treatments in MM patients must be regarded as the main limitation of this work.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Apical Periodontitis in patients with Multiple Myeloma

Sánchez¹,

Pérez-Díaz²,

Fj³

et al. 2020

Med Oral

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Background: Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. Material and Methods: Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical index (PAI). Data included systemic health, technical quality of root fillings, total number of teeth, quality of restoration, and periapical status. Statistical evaluation of differences between groups used chi-squared tests and Fisher's exact tests. Results: The prevalence of root canal-treated teeth was 10.11% in the MM group and 12.05% in the control group (p=0.90). The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p=0.05). AP in 1 or more teeth was found in 86 % and in 78% of the patients in the MM and the control groups, respectively. When analyzed by subject, there was no statistically significant difference in the prevalence of AP (p>0.72). Similarly there was also no statistically significant difference in the prevalence of PA (p=0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups. Conclusions: The presence of AP and endodontic treatment was not significantly different in individuals with MM compared with control subjects. Future studies are needed to elucidate and confirm the association between MM and AP.

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“…Studies that have evaluated the need for endodontic treatment in different communities have found values that are much less expressive than those observed here. These values were 14%, 10.2%, and 23.2% in HIV-positive patients, 4 in patients with sickle cell disease, 5 and in patients undergoing bone marrow transplantation, 6 respectively. In this study, the Sateré-Mawé ethnic group presented a higher prevalence of endodontic treatment compared to the Tikuna ethnic group, which can be explained by the great difficulty of access to dental health services and the absence of educational and preventive actions to promote oral health.…”

mentioning

confidence: 88%

Epidemiological analysis and need for endodontic treatment among the indigenous Sateré-Mawé and Tikuna

et al. 2018

Self Cite

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The objective of this study was to analyze the epidemiological profile of oral health of Sateré-Mawé indigenous people living in Barreirinha, Amazonas (AM), Brazil, and the Tikuna indigenous people living in the urban area of Manaus (AM), in addition to characterizing the need for endodontic treatment between the two ethnic groups. A total of 138 individuals participated in the study, of whom 98 were Tikuna and 40 were Sateré-Mawé; they were distributed in age groups ranging from seven to 75 years. A very high prevalence of caries was observed in both ethnic groups. For the Sateré-Mawé in the 7-12 age group, the decayed, missing, and filled teeth (DMFT) index presented a mean value of 3.17. Comparing the DMFT index and the need for endodontic treatment in each of the ethnicities, these variables were found to be correlated, because as the DMFT index increases, the chances of needing endodontic treatment increase. The Sateré-Mawé presented a higher prevalence of need for endodontic treatment compared to the Tikuna. The association of comorbidities and the need for endodontic treatment were demonstrated only in the Tikuna, and there was only a correlation of this necessity with the presence of diabetes mellitus (DM) in one case. The need to expand access to oral health in these communities is emphasized, taking into account geographical access and technological, environmental, linguistic, and cultural barriers.

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The need for endodontic treatment and systemic characteristics of hematopoietic stem cell transplantation patients

Cited by 4 publications

References 32 publications

Short-Term Impact of Hematopoietic Stem Cell Transplantation in Leukemia Patients on Bone Bio Markers, Electrolytes and Blood Profile

Short-Term Impact of Hematopoietic Stem Cell Transplantation in Leukemia Patients on Bone Bio Markers, Electrolytes and Blood Profile

Prevalence of Apical Periodontitis in patients with Multiple Myeloma

Epidemiological analysis and need for endodontic treatment among the indigenous Sateré-Mawé and Tikuna

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