IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

Görgün, Emine Pirim; Toker, Hülya; Korkmaz, Ertan Mahir; Poyraz, Ömer

doi:10.1590/1807-3107bor-2017.vol31.0012

Cited by 19 publications

(16 citation statements)

References 40 publications

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“…In a meta-analysis including four case-control studies, the IL-6 −174G allele was found to be a risk factor for AgP, but not for CP development [ 24 ]. Although the findings regarding IL-6 −174 C/G (rs1800795) and AgP in the Turkish population are controversial [ 77 , 78 ], no association of this SNP with AgP was found in the Italian population, which is in accordance with results of our previous study on the Czech population [ 64 ]. Interestingly, haplotypes formed by several IL-6 SNPs including IL-6 −174 C/G (rs1800795) displayed significant association with the localized AgP but not with the generalized AgP phenotype in Caucasians [ 79 ].…”

Section: Discussionsupporting

confidence: 87%

Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis

Linhartová

Daněk

Deissová

et al. 2020

IJMS

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Host genetic predispositions to dysregulated immune response can influence the development of the aggressive form of periodontitis (AgP) through susceptibility to oral dysbiosis and subsequent host-microbe interaction. This case-control study aimed to perform a multilocus analysis of functional variants in selected interleukin (IL) genes in patients with the generalized form of AgP in a homogenous population. Twelve polymorphisms in IL-1 gene cluster, IL-6 and its receptor, IL-10, IL-17A, and IL-18 were determined in 91 AgP patients and 210 controls. Analysis of seven selected periodontal bacteria in subgingival sulci/pockets was performed with a commercial DNA-microarray kit in a subgroup of 76 individuals. The pilot in vitro study included stimulation of peripheral blood monocytes (PBMC) from 20 individuals with periodontal bacteria and measurement of IL-10 levels using the Luminex method. Only the unctional polymorphism IL-10 −1087 A/G (rs1800896) and specific IL-10 haplotypes were associated with the development of the disease (p < 0.05, Pcorr > 0.05). Four bacterial species occurred more frequently in AgP than in controls (p < 0.01, Pcorr < 0.05). Elevated IL-10 levels were found in AgP patients, carriers of IL-10 −1087GG genotype, and PBMCs stimulated by periodontal bacteria (p < 0.05, Pcorr > 0.05). We therefore conclude that a combination of genetic predisposition to the altered expression of IL-10 and the presence of specific periodontal bacteria may contribute to Th1/Th2 balance disruption and AgP development.

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Section: Discussionsupporting

confidence: 87%

Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis

Linhartová

Daněk

Deissová

et al. 2020

IJMS

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“…Several researches on the clinical utility of cytokine genotyping for periodontal disease were conducted, but the genetic knowledge of periodontitis pathogenesis and effects on treatment results is still limited. Previously, we reported that IL-6 (-174) GG genotype caused an increase in GCF IL-10 levels without affecting periodontal treatment outcomes and we also found that SNPs in IL-6 (-174) and IL-10 (-597) were associated with generalized aggressive periodontitis (GAgP) 18 . However, there is no information regarding the ratio of inflammatory markers (IL-6/IL-10) in different genotype distribution of IL-10 gene in chronic periodontitis.…”

Section: Introductionmentioning

confidence: 69%

The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis

et al. 2018

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ObjectiveAnti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. The purpose of this study was to evaluate the effect of interleukin-10 (-597) gene polymorphism and genotype distributions on chronic periodontitis (CP) development and IL-6 and IL-10 levels in gingival crevicular fluid (GCF) and serum before and after non-surgical periodontal treatment.Material and MethodsThe study population consisted of 55 severe generalized CP patients as CP group and 50 healthy individuals as control group. Plaque index, gingival index, probing depth and clinical attachment level were recorded and GCF and blood samples were taken at both the baseline and the sixth week after non-surgical periodontal treatment. PCR-RFLP procedure was used for gene analyses and cytokine levels were measured via ELISA.ResultsIL-10 genotype distribution was significantly different between CP and control groups (p=0.000, OR:7, 95%CI, 2.83-60.25). Clinical measurements significantly improved in the CP group after periodontal treatment (p<0.05). Periodontal treatment significantly decreased GCF IL-6 and IL-10 levels. No significant difference was found in clinical parameters between IL-10 AA and AC+CC genotypes at both the baseline and the sixth week (p>0.05). Sixth week GCF IL-10 levels were significantly lower in patients carrying IL-10 AC+CC genotype compared to the patients carrying IL-10 AA genotype (p<0.05). Serum IL-6 and IL-10 levels were lower in patients carrying the IL-10 AA genotype compared to patients with IL-10 AC+CC genotype, but the difference was not significant (p>0.05).ConclusionIL-10 AA genotype carriers had lower IL-6 and IL-6/10 levels in serum; however, GCF IL-6/10 levels were similar in both genotypes. Within the limitations of our study, a possible association between IL-10(-597) gene polymorphism and CP might be considered.

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“…The publication dates of the 23 included studies ranged from 2002 to 2018; 2714 periodontitis patients and 2373 periodontitis-free control subjects from 9 different countries were studied. Six of the included studies reported on Asians, [23,29,31,36–38] 13 studies reported on Caucasians, [15,17,18,19,21,25–28,31,33–35] and the last 4 studies reported on Brazilians. [20,22,24,32] In terms of the type of periodontitis, 13 studies focused on chronic periodontitis (CP), [18,20–22,24,26,27,31,33–35,37,38] 3 studies focused on aggressive periodontitis (AgP), [28,31,36] and 7 studies focused on both CP and AgP.…”

Section: Resultsmentioning

confidence: 99%

“…Six of the included studies reported on Asians, [23,29,31,36–38] 13 studies reported on Caucasians, [15,17,18,19,21,25–28,31,33–35] and the last 4 studies reported on Brazilians. [20,22,24,32] In terms of the type of periodontitis, 13 studies focused on chronic periodontitis (CP), [18,20–22,24,26,27,31,33–35,37,38] 3 studies focused on aggressive periodontitis (AgP), [28,31,36] and 7 studies focused on both CP and AgP. [15,17,19,23,25,29,32] The subjects of 14 studies were nonsmoker, [15,18,19,21,22,24,26–30,31–33] 4 studies included both smokers and nonsmoker (mixed group), [23,25,34,35] and 5 studies did not provide this information.…”

Section: Resultsmentioning

confidence: 99%

Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility

Wang

Zhou

et al. 2019

Medicine

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IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

Cited by 19 publications

References 40 publications

Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis

Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis

The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis

Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility

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