Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers

Weckwerth, Paulo Henrique; Lima, Fellipe Lombardo de Souza; Greatti, Vanessa Raquel; Duarte, Marco Antônio Húngaro; Vivan, Rodrigo Ricci

doi:10.1590/1807-3107bor-2015.vol29.0073

Cited by 7 publications

(11 citation statements)

References 25 publications

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“…Most of the studies investigated the antimicrobial efficacy of MTA Fillapex. Nineteen studies used planktonic cells [16,33,34,38,45,46,48,50,52–62] while four studies used either young biofilms [38,49] or mature biofilms [37,40].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

et al. 2019

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BackgroundRecently, a new generation of bioceramic root canal sealers has been introduced onto the market. Many in vitro studies have investigated the antimicrobial properties of these sealers, but their comparative efficacy in antimicrobial activity is still unknown.MethodologyThree electronic databases were searched: MEDLINE and Embase via the OvidSP platform, and Web of Science, up to June 25, 2019. Studies were included irrespective of study design, type of publication and language. Reporting quality was assessed by two authors independently. Meta-analysis was not performed due to studies being highly heterogeneous.ResultsWe included 37 studies that analysed the antimicrobial effects of bioceramic sealers. Most of them used a planktonic cell model, with the exception of nine studies which used biofilms. It was not possible to make direct comparison of results from studies and to give a clear conclusion about the comparative antimicrobial activity of these materials because the studies used heterogeneous sources and ages of microorganisms, setting and contact times of sealers, and antimicrobial tests. Furthermore, some materials showed completely different results when tested with different methods.ConclusionsIn conclusion, multiple in vitro studies have shown that bioceramic sealers may have various degrees of antimicrobial activity. However, it is still impossible to make conclusions about their comparative efficacy and to recommend the use of one over another in clinical practice because the studies available were conducted in different ways, which makes meta-analysis futile. A uniform methodological approach, consistent definitions and studies on humans are urgently needed in this field of research so that recommendations for practice can be made.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

et al. 2019

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“…According to the American National Standards Institute/American Dental Association (ANSI/ADA), the setting time cannot exceed 10% of the time specified by the manufacturer [10, 25]. In this study, the control groups exceeded the recommended setting times, and the incorporation of AgVO 3 decreased the setting time for the modified groups of AH Plus and delayed for the modified groups of Sealer 26 and Endomethasone N. Studies that evaluated the incorporation of antimicrobials (QPEI, benzalkonium chloride, and iodoformium nanoparticles [26, 27]) into endodontic sealers also showed an increase in setting time.…”

Section: Discussionmentioning

confidence: 99%

Endodontic Sealers Modified with Silver Vanadate: Antibacterial, Compositional, and Setting Time Evaluation

Teixeira

Silva

Alves

et al. 2019

BioMed Research International

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The incorporation of nanoparticles into endodontic sealers aims at increasing antimicrobial activity of the original material. Aim. The aim of this study is to incorporate the nanostructured silver vanadate decorated with silver nanoparticles (AgVO3, at 2.5%, 5%, and 10%) into three endodontic sealers and evaluate the antibacterial activity of freshly sealers, surface topography and chemical composition, and setting time. Material and Methods. The AgVO3 was incorporated into AH Plus, Sealer 26, and Endomethasone N at concentrations 0%, 2.5%, 5%, and 10% (in mass). The antibacterial activity of freshly sealers was assessed by direct contact with Enterococcus faecalis and CFU/mL count (n=10), surface topography, and chemical composition were measured by SEM/EDS, and the setting time was measured by Gillmore needle (n=10). The Kruskal-Wallis and Dunn statistical tests were applied (α=0.05). Results. All groups of sealers evaluated inhibited E. faecalis (p>0.05). The incorporation of AgVO3 altered the atomic proportions between components of the endodontic sealers, and the percentage of silver (Ag) and vanadium (V) increased proportionally to the concentrations of AgVO3. Topography analysis showed differences in components distribution on the surface of the specimens. The sealers incorporated with AgVO3 of AH Plus presented a lower setting time than the control group (p<0.05). For Sealer 26 and Endomethasone N, the incorporation of AgVO3 increased the setting time in relation to control group (p<0.05). Conclusions. The modification of endodontic sealers by AgVO3 increased the atomic percentage of Ag and V proportionally to the concentration of the nanomaterial and changed the atomic percentage of the sealer components and setting times. It cannot be affirmed that the AgVO3 promote differences in the antimicrobial activity of freshly sealers, and further investigations of the antimicrobial activity of the set sealers should be carried out.

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“…Classification of the antibacterial additives discussed in the review is shown in Figure 2. Of the 31 papers included, 11 [31,32,36,37,38,39,40,41,42,43,44] evaluated the effect of antiseptic additives, including natural agents (plant extracts) [42,43], two publications tested calcium hydroxide as an additive [45,46], 5 [23,24,25,28,47], and one [48] evaluated the effects of antibiotic and antifungal additives, respectively. Nanoparticles and/or nanoparticles functionalised with antimicrobial agents were studied in 12 papers [21,49,50,51,52,53,54,55,56,57,58,59].…”

Section: Reviewmentioning

confidence: 99%

“…Nanoparticles and/or nanoparticles functionalised with antimicrobial agents were studied in 12 papers [21,49,50,51,52,53,54,55,56,57,58,59]. The epoxy resin-based sealers used in the studies were AH Plus™ (Dentsply DeTrey, Konstanz, Germany) [23,24,25,31,32,38,39,40,41,42,43,45,46,47,48,49,50,51,52,53,54,56,57,58,59], AH 26™ (Dentsply DeTrey, Konstanz, Germany) [24,28,57], Sealer 26™ (Dentsply, Indústria e Comércio Ltda., Petrópolis, RJ, Brazil [48,50,51,52], Dentsply, Maillefer Instruments SA, Ballaigues, Switzerland [44]), ThermaSeal Plus™ (Dentsply Tulsa Dental, Tulsa, OK, USA) [21], MM-Seal ™ (MicroMega, Besançon, France) [36], BJM Root Canal Sealer™ (B.J.M. Laboratories, Or-Yehuda, Israel) [36,37], and RCS™ (B.J.M.…”

Section: Reviewmentioning

confidence: 99%

“…However, the authors also explained the limitations of the technique used, wherein dental materials with better diffusion ability may show bigger inhibition halos. The authors attempted to minimize the risk of diffusion of the chemicals through the agar before incubation by a pre-incubation period by leaving the plates for 2 h at room temperature [48]. Nevertheless, these manipulations may not prevent errors in evaluating the results.…”

Section: Review Of Antimicrobial Effectsmentioning

confidence: 99%

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Antibacterial Additives in Epoxy Resin-Based Root Canal Sealers: A Focused Review

et al. 2019

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Dental materials used in root canal treatment have undergone substantial improvements over the past decade. However, one area that still remains to be addressed is the ability of root canal fillings to effectively entomb, kill bacteria, and prevent the formation of a biofilm, all of which will prevent reinfection of the root canal system. Thus far, no published review has analysed the literature on antimicrobial additives to root canal sealers and their influence on physicochemical properties. The aim of this paper was to systematically review the current literature on antimicrobial additives in root canal sealers, their anti-fouling effects, and influence on physicochemical properties. A systematic search was performed in two databases (PubMed and Scopus) to identify studies that investigated the effect of antimicrobial additives in epoxy resin-based root canal sealers. The nature of additives, their antimicrobial effects, methods of antimicrobial testing are critically discussed. The effects on sealer properties have also been reviewed. A total of 31 research papers were reviewed in this work. A variety of antimicrobial agents have been evaluated as additives to epoxy resin-based sealers, including quaternary ammonium compounds, chlorhexidine, calcium hydroxide, iodoform, natural extracts, antibiotics, antifungal drugs, and antimicrobial agent-functionalised nanoparticles. Antimicrobial additives generally improved the antimicrobial effect of epoxy resin-based sealers mainly without deteriorating the physicochemical properties, which mostly remained in accordance with ISO and ANSI/ADA specifications.

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Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers

Cited by 7 publications

References 25 publications

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

Endodontic Sealers Modified with Silver Vanadate: Antibacterial, Compositional, and Setting Time Evaluation

Antibacterial Additives in Epoxy Resin-Based Root Canal Sealers: A Focused Review

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