Efficacy of a triclosan formula in controlling early subgingival biofilm formation: a randomized trial

Abstract

The aim of this study was to determine the efficacy of rinses with slurries of a dentifrice containing triclosan (TCS), as compared with rinses with slurries from a control dentifrice, in controlling early subgingival biofilm formation. A double-blind, randomized and cross-over clinical trial was designed, and 26 dental students were included. In the first period, participants were randomized to rinse with a TCS slurry or a control slurry, in a 12 h interval, and to refrain from mechanical cleaning. A Plaque Free Zone Index was assessed at 24 h, 48 h, 72 h and 96 h. After a washout period of 10 days, the second experimental period was conducted, following the same protocol as the first period, except that the slurry groups were switched. Use of the TCS slurry resulted in a significantly higher percentage of plaque-free surfaces, both at 24 h and at 72 h (p < 0.01). In the of 48-72 h interval, the triclosan slurry showed a lower percentage of sites converted to a score of 2 (38.1% for the test versus 40% for the control product, p = 0.015).In conclusion, rinsing with slurries of dentifrice containing TCS retards the down growth of bacterial biofilms from the supra-to the subgingival environment.

Conhecimento dos cirurgiões-dentistas da capital de um estado do nordeste brasileiro sobre a utilização de agentes químicos como coadjuvantes na terapia periodontal

“…O objetivo dos agentes anti-biofilme e anti-gengivite é diminuir a inflamação gengival de modo que a doença periodontal destrutiva não se desenvolva ou tenha seu curso interrompido. Vários produtos anti-gengivite e anti-biofilme estão disponíveis comercialmente para os pacientes, e estes produtos são principalmente na forma de dentifrício ou enxaguatório bucal, onde a formulação adequada é importante tanto para manter a biodisponibilidade como para melhorar a substantividade (Andrade, Weidlich, Angst, Gomes & Oppermann, 2015). Alguns agentes estão adicionados nos dentifrícios com funções terapêuticas como anti-biofilme e anti-cálculo.…”

“…O Triclosan (TRI) retarda o crescimento descendente de biofilme do ambiente supra para o subgengival, e tem a vantagem conhecida da adsorção e liberação de agentes químicos no meio oral (Andrade, Weidlich, Angst, Gomes & Oppermann, 2015). A metanálise feita por Gunsolley (2006) demonstrou que o copolímero gantrez é um elemento necessário para que o triclosan funcione de maneira adequada e com uma elevada substantividade Outro agente químico disponível no mercado é o Cloreto de Cetilpiridínio (CCP) que é um agente antimicrobiano (Miranda et al, 2020) e que tem propriedades catiônicas que ajudam a manter sua substantividade, o ensaio randomizado de Amini, Araujo, Mei-miau, Charles e Sharma (2009) utilizando um modelo experimental de gengivite apresentou redução no índice de biofilme quando utiliza-se CCP 2x por dia durante 2 semanas.…”

Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness

“…In children of aggressive periodontitis parents, a TRC toothpaste was demonstrated to be efficient in the management of the periodontal condition through the reduction of bleeding on probing, pocket depth, salivary Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ) and inflammatory markers [ 129 ]. This compound inhibits the subgingival biofilm formation and the overnight plaque [ 130 , 131 ], but its use has been controversial due to possible associations with low neonatal birth weight [ 132 , 133 ].…”

Chlorhexidine with or without alcohol against biofilm formation: efficacy, adverse events and taste preference

“…Maliska et al described an index to evaluate the presence of early subgingival biofilm formation, and found that an alcohol-containing 0.12% chlorhexidine solution reduced the number of dental surfaces bearing subgingival biofilm more than tenfold, compared with placebo 9 . The same index was used to demonstrate that triclosan could postpone early subgingival formation in the interdental area 10 . The potential of an alcohol-free chlorhexidine solution to prevent subgingival biofilm buildup has not been reported in the literature.…”