Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

Jacinto, Rogério de Castilho; Linhares-Farina, Giane; Sposito, Otávio da Silva; Zanchi, César Henrique; Cenci, Maximiliano Sérgio

doi:10.1590/1807-3107bor-2015.vol29.0036

Cited by 12 publications

(12 citation statements)

References 29 publications

(23 reference statements)

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“…For this reason, laboratory studies assessing the setting times and the solubility of endodontic cements may be of interest to clinicians. In our study, the final setting time of conventional MTA was about 84 min, in agreement with previous studies 21 , 25 . MTA Repair HP showed a similar final setting time (85 min), without statistical differences when compared with conventional MTA.…”

Section: Discussionsupporting

confidence: 92%

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem

et al. 2018

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ObjectiveThis study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials.Material and methodsWe tested MTA Repair HP and MTA Vitalcem in comparison with conventional MTA, analyzing radiopacity and final setting time. Water absorption, interconnected pores and apparent porosity were measured after 24-h immersion in deionized water at 37°C. Calcium and pH were tested up to 28 d in deionized water. We analyzed data using two-way ANOVA with Student-Newman-Keuls tests (p<0.05). We performed morphological and chemical analyses of the material surfaces using ESEM/EDX after 28 d in HBSS.ResultsMTA Repair HP showed similar radiopacity to that of conventional MTA. All materials showed a marked alkalinizing activity within 3 h, which continued for 28 d. MTA Repair HP showed the highest calcium release at 28 d (p<0.05). MTA Vitalcem showed statistically higher water sorption and solubility values (p<0.05). All materials showed the ability to nucleate calcium phosphate on their surface after 28 d in HBSS.ConclusionsMTA Repair HP and MTA Vitalcem had extended alkalinizing activity and calcium release that favored calcium phosphate nucleation. The presence of the plasticizer in MTA HP might increase its solubility and porosity. The radiopacifier calcium tungstate can be used to replace bismuth oxide.

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Section: Discussionsupporting

confidence: 92%

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem

et al. 2018

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“…Therefore, using intracanal medicament is necessary to protect the root canal system during root canal treatment. 35,36 Several additives have been combined with MTA to enhance the working properties of the cement. It has been demonstrated that NaOCl gel may reduce the setting time and improve the handling characteristics of the mixture.…”

Section: Discussionmentioning

confidence: 99%

<p>Calcium Silicate-Based Cements as Root Canal Medicament</p>

Mahmoud

Al-Meeri

Farook

et al. 2020

CCIDE

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Purpose: This study aims to retard the setting reaction of CSC by mixing it with 2% chlorhexidine gel (CHX) which will be used as an intracanal medicament, and to evaluate the removal of the experimental medicaments from the root canal. Materials and Methods: White Portland cement, white ProRoot MTA and Biodentine were mixed with 2% CHX. The setting time, flowability and film thickness of the CSC/CHX mixture (experimental medicaments) were assessed and measured following the standards of ISO specification. Calcium ion release was measured using ICP-OES, while pH was tested using a pH meter. Moreover, twenty single-rooted teeth were filled with the experimental medicaments for seven days, then the medicaments were removed and the samples analyzed using SEM. Calcium hydroxide paste was used as a control. Results: The setting time of the experimental medicaments was inhibited until 84 days. The calcium ion release of the experimental medicaments was significantly higher compared to the control over the period of 14 days (P<0.001). The mean pH value was above 11.45 for all tested materials over a period of 14 days, with no significant difference between them (P<0.05). There was no significant difference in film thickness of the experimental medicaments compared to the control (P> 0.05). However, the flowability of the experimental medicaments was significantly higher than the control (P<0.05). SEM showed no significant differences in the removal of the intracanal medicaments between all the tested groups. Conclusion: The addition of 2% CHX to CSCs retarded or inhibited its setting reaction over a period of 84 days. The calcium ion release and flowability of these experimental medicaments was found to be better than calcium hydroxide. Removal of the intracanal medicaments from the root canal was successfully achieved in all groups. Therefore, these experimental medicaments have the potential to be used as an enhanced root canal medicament.

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“…Its mechanisms of action have been described based on its composition. Structural characteristics of MTA allow a continuous hydration reaction, forming calcium hydroxide, which dissociates and releases calcium ions into the medium (15). When the released calcium ions come into contact with fluid tissues, they produce hydroxyapatite (16).…”

Section: Discussionmentioning

confidence: 99%

“…Although MTA has many favorable properties that support its clinical use, there are also negative points, like its difficult manipulation, absence of antimicrobial activity and also its extended setting time (15). Recent studies have addressed different formulations (25) or manipulations of MTA (15), aiming at having a better MTA on the market. Finally, little difference was observed between control and MTA groups.…”

Section: Discussionmentioning

confidence: 99%

Experimental Furcal Perforation Treated with MTA: Analysis of the Cytokine Expression

et al. 2015

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The aim of this study was to evaluate mineral trioxide aggregate (MTA)-induced cytokine expression in mice after experimental furcal perforation. BALB/c mice (n=5) were subjected to induced furcal drilling of the maxillary first molar followed by MTA sealing in the left side (experimental group) and paraffin sealing in the right side (control group). Animals were euthanized at 7, 14 and 21 days after sealing the perforations. The expression levels of the IFN-γ, TNF-α, IL-10, IL-4, TGF-β and RANKL genes were investigated by real time polymerase chain reaction (PCR) in the teeth and surrounding tissues. In the experimental groups, after the 7th day, there was a down-regulation of the mRNA levels of TNF-α and IL-4 compared to the 14th day (p<0.05). In these groups, the mRNA levels of RANKL, IFN-γ and TNF-α were statistically higher after 14 days compared to 21 days post-MTA sealing (p<0.05). The level of IL-10 mRNA was increased at the 21st day (p<0.05). The mRNA expression of TGF-β did not exhibit any statistically relevant results. There was a statistical down-regulation of IL-4 gene expressions when control and experimental groups were compared at days 7 and 21. In conclusion, MTA sealing favored the expression of pro-inflammatory cytokines in the intermediate phase of the immuno-inflammatory response (14th day). The reduction of these cytokines in later phase of the response was probably due to immunoregulation by IL-10.

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Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

Cited by 12 publications

References 29 publications

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem

<p>Calcium Silicate-Based Cements as Root Canal Medicament</p>

Experimental Furcal Perforation Treated with MTA: Analysis of the Cytokine Expression

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