The objective of this study was to evaluate the production and nutrition of safflower under different densities of soil and nitrogen rates in Oxisol. The experiment followed a randomized complete block design and was performed in a greenhouse in a factorial 5x5 fractionated scheme (5²), involving five soil densities (1.0, 1.2, 1.4, 1.6, and 1.8 Mg m -3 ) and five nitrogen rates (0, 50, 100, 150, and 200 mg dm -3 ), with four replications. The variables analyzed included the chlorophyll index, dry mass of the shoot, dry mass of the head, and concentration of nitrogen accumulation in the shoots and heads. The dry mass and nitrogen accumulation in the shoot and heads of the safflower showed a 50-53% drop as the soil density increased. Nitrogen rate of 149 and 179 mg dm -3 produced a higher chlorophyll index and nitrogen concentration in the safflower plant heads, respectively. The concentration and shoot nitrogen accumulation revealed a 49% and 37% rise, respectively, with increased nitrogen fertilization. As the soil density and nitrogen levels influence the production and nutrition of safflower, they were isolated.