Investigation of rs1800469 and rs1800468 Polymorphisms of the TGF-β1 Gene in Women with Pre-eclampsia

Abstract

Objectives: to verify the contribution of polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and the risk factors for the pre-eclampsia development.Methods: this is a case-control study with 257 women from the Uberaba region of Minas Gerais were selected, 88 of them were in the pre-eclampsia group and 169 in the control group. Genotyping was performed by allelic discrimination using the real-time PCR technique. The odds ratio and the 95% confidence interval were used to evaluate the probability of the polymorphisms studied contributing for the pre-eclampsia development. The logistic regression analysis was performed to evaluate the relation among family recurrence, smoking, primiparity and the presence of polymorphic alleles and susceptibility of preeclampsia.Results: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 gene and pre-eclampsia. The logistic regression analysis was statistically significant for family recurrence, showing that women with a family history of pre-eclampsia and primiparity are at an increased risk of developing the disease.Conclusions: no association was found between polymorphisms rs1800469 and rs1800468 of the TGF-β1 and pre-eclampsia gene. Factors such as family history and primiparity were associated to the risk of developing pre-eclampsia. 184Cancian-Hortolani AC et al.

Gene polymorphism associated with TGF‐β1 and susceptibility to preeclampsia: A meta‐analysis and trial sequential analysis

“…After application of the criteria, 14 studies were kept (Figure 1). Characteristics of the 11 studies are shown in Table 1 13–26 . The published year ranged from 2006 to 2019.…”