Potential impact of the COVID-19 in HIV-infected individuals: a systematic review Impact of the COVID-19 in HIV-Infected Individuals

Medeiros, Kleyton Santos de; Silva, Luís Antônio Soares da; Macêdo, Luíza Thomé de Araújo; Sarmento, Ayane Cristine Alves; Costa, Ana Paula Ferreira; Eleutério, José; Gonçalves, Ana Katherine

doi:10.1590/1806-9282.67.suppl1.20200754

Cited by 12 publications

(3 citation statements)

References 45 publications

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“…Several reviews have attempted to synthesise outcome information for HIV patients with COVID-19 [12][13][14][15][16][17]50]. However, these studies have either included preprints and therefore unpublished articles in peerreviewed journals, or they have meta-analysed unadjusted estimators, ignoring the potential difference in the composition of the study populations and, more importantly, the presence of factors such as co-morbidities other than HIV that could influence outcomes in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, patients with hypertension, obesity and diabetes are more likely to die, be admitted to intensive care units and have severe forms of the infection [9][10][11]. For some other diseases such HIV, the information on their association with adverse outcomes in patients with COVID-19 are conflicting [12][13][14][15][16][17]. However, some regions of the world like sub-Saharan Africa are at risk of having a burden of COVID-19 drive by the proportion of HIV patients.…”

Section: Introductionmentioning

confidence: 99%

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Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis

et al. 2022

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Background Data on the association of human immunodeficiency virus (HIV) infection with adverse outcomes in patients with COVID-19 are conflicting. This systematic review and meta-analysis aimed to summarize the available information on the risk of hospitalization, severe disease, and death attributable to HIV in patients with COVID-19. Methods PubMed, EMBASE, Web of Science, and SCOPUS were searched through October 25, 2021, to identify relevant studies, without language restriction. A random-effects model was used to pool estimates. Results We included 44 studies reporting information from 38,971,065 patients with COVID-19. The pooled prevalence of HIV among COVID-19 patients was 26.9 ‰ (95% CI 22.7–31.3) and was significantly higher in studies conducted in Africa compared to those conducted elsewhere (118.5‰ [95% CI 84.8–156.9, 11 studies] vs 10.9‰ [95% CI 8.8–13.2, 27 studies]). In pooled analyses of unadjusted odds ratio, HIV-positive individuals were more likely to be admitted to hospital (OR: 1.49; 95% CI 1.01–2.21, 6 studies) compared to HIV-negative individuals. In the adjusted (for age and sex) analyses, HIV was associated with an increased risk of death (hazard ratio: 1.76, 95% CI 1.31–2.35, 2 studies). However, HIV was not associated with the severity of the disease (OR: 1.28; 95% CI 0.77–2.13, 13 studies), or death (OR: 0.81; 95% CI 0.47; 1.41, 23 studies) in patients with COVID-19 in the meta-analysis of unadjusted odds ratio. Conclusion Our findings suggest that patients with HIV have an increased risk of hospital admission for COVID-19. HIV seems to be independently associated with increased risk of mortality in COVID-19 patient in adjusted analysis. However, this evidence was derived from only two studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis

et al. 2022

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“…Tem sido também investigado o papel do interferon na coinfecção de HIV e covid-19, onde o interferon tipo I parece ajudar a conter a infecção por SARS-CoV-2 (Medeiros et al, 2021). Além disso, há estudos sugerindo que o uso regular de medicamento antirretroviral no tratamento do HIV pode desempenhar papel protetor contra a covid-19, estando, inclusive, associado o uso de antirretroviral com um melhor prognóstico para o curso da covid-19 (Huang et al, 2022) e a um menor risco de internação (Del Amo et al, 2020).…”

Section: Resultsunclassified

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

De Santana,

Pinheiro,

Montarroyos

2024

CLCS

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A doença covid-19 tem amplo espectro de apresentação clínica, que vai desde indivíduos que não manifestam sintomas aos pacientes com doença respiratória grave que podem progredir para o óbito. Pessoas que vivem com HIV são particularmente mais vulneráveis a contrair o SARS-CoV-2 e a desenvolver formas graves da doença, tendo, inclusive, maior risco de hospitalização e morte. Ainda há muito a ser investigado sobre o HIV e a covid-19, então o objetivo deste estudo foi explorar os principais aspectos clínicos e biológicos da coinfecção. Assim sendo, este estudo se trata de uma revisão sistemática sobre a coinfecção de HIV e covid-19 elaborada a partir de um levantamento de artigos publicados de março de 2020 a dezembro de 2023 nas bases de dados SCIELO, BVS e Pubmed. Os descritores utilizados foram covid-19, vírus SARS-CoV-2, HIV, coinfecção, sintomas e biologia, sendo feita a combinação entre estes descritores através do operador booleano ‘’and’’. Após aplicação dos critérios de inclusão e exclusão, 28 artigos foram selecionados para a construção da revisão sistemática. Em relação aos achados clínicos da coinfecção de covid-19 e HIV, observou-se que os sintomas mais comumente encontrados foram semelhantes aos de pacientes com covid-19 e sem HIV e, dentre eles, os mais frequentes foram febre, tosse, dispneia e mialgia. No que diz respeito aos aspectos biológicos da coinfecção de HIV e covid-19, ambas as doenças provocam desregulação do sistema imune do hospedeiro, o que justifica a alta morbimortalidade decorrente da coinfecção.

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HIV Testing Disruptions and Service Adaptations During the COVID-19 Pandemic: A Systematic Literature Review

Mude,

Mwenyango,

Preston

et al. 2023

AIDS Behav

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Access to treatment and care in safe clinical settings improves people’s lives with HIV. The COVID-19 pandemic disrupted vital HIV programs and services, increasing the risk of adverse health outcomes for people with HIV and HIV transmission rates in the community. This systematic literature review provides a meta-analysis of HIV testing disruptions and a synthesis of HIV/AIDS services adapted during COVID-19. We searched scholarly databases from 01 January 2020 to 30 June 2022 using key terms on HIV testing rates and services during the COVID-19 pandemic. The process of how the included articles were identified, selected, appraised, and synthesised was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included 17 articles that reported changes in HIV testing during the COVID-19 pandemic and 22 that reported adaptations in HIV/AIDS services. We found that HIV testing decreased by 37% during the search period because of the COVID-19 pandemic. Service providers adopted novel strategies to support remote service delivery by expanding community antiretroviral therapy dispensing, setting up primary care outreach points, and instituting multi-month dispensing services to sustain client care. Therefore, service providers and policymakers should explore alternative strategies to increase HIV testing rates impacted by COVID-19 and leverage funding to continue providing the identified adapted services.

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Potential impact of the COVID-19 in HIV-infected individuals: a systematic review Impact of the COVID-19 in HIV-Infected Individuals

Cited by 12 publications

References 45 publications

Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis

Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

HIV Testing Disruptions and Service Adaptations During the COVID-19 Pandemic: A Systematic Literature Review

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