Correlation between venous blood gas indices and radiological involvements of COVID-19 patients at first admission to emergency department

Dheir, Hamad; Karacan, Alper; Sipahi, Savaş; Yaylacı, Selçuk; Toçoğlu, Aysel; Demirci, Taner; Çetin, Esma Seda; Güneysu, Fatih; Fırat, Necattin; Varım, Ceyhun; Karabay, Oğuz

doi:10.1590/1806-9282.67.suppl1.20200715

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Arterial blood gases are reliable tests to evaluate mortality in COVID-19, as described in previous studies (19)(20)(21)(22). In a study by Bruno et diastolic pressure, neutrophils, lymphocytes, CRP, procalcitonin, lactate dehydrogenase, and D-dimer were significantly correlated with death events.…”

Section: Resultsmentioning

confidence: 75%

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

Saruhan

ÖZDEMİR

Acar

2022

Anatolian Current Medical Journal

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Aim: It is critical to categorize the risk factors that could disclose the severity of COVID-19. This study aimed to determine the effects of arterial blood gases on hospital mortality by examining the results retrospectively measured at the first admission to the emergency department of cases diagnosed with COVID-19. Material and Method: In this retrospective study, arterial blood gases of patients with COVID-19 were analyzed using univariate analysis to identify factors linked to 28-day all-cause in-hospital mortality. The patients were divided into two groups survivors and nonsurvivors. Results: The study included 159 survivors and 33 nonsurvivors with COVID-19. Serum levels of lactate, D-dimer, troponin, and CRP were higher and serum levels of base excess, bicarbonate, and albumin to creatinine ratio were lower in nonsurvivor patients than in survivors. The highest AUC was found for lactate and base excess. Conclusion: The arterial blood gases performed during the first admission to the emergency department are linked with disease severity and can be used to predict disease progression and mortality. Furthermore, patients with higher levels of lactate and lower levels of base excess and bicarbonate should be monitored closely and treated early.

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Section: Resultsmentioning

confidence: 75%

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

Saruhan

ÖZDEMİR

Acar

2022

Anatolian Current Medical Journal

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“…Moreover, higher PCO 2 levels might be associated with a lower risk of long COVID as COPD patients with chronic hypercapnia are accustomed to lower oxygen levels in the blood, possibly resulting in less respiratory complaints. Previous research has demonstrated that decreased PCO 2 levels are associated with more severe involvement on chest CT, need for intubation, and risk of mortality during acute COVID-19 [42‒44].…”

Section: Discussionmentioning

confidence: 99%

Predictors for Long COVID and Differences in Long COVID Symptoms, Findings on Chest Imaging and Pulmonary Function between Hospitalized COVID-19 Patients with versus without Intensive Care Unit Admission

van Wincoop,

Moeniralam,

Schramel

2024

Respiration

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Introduction Many COVID-19 survivors suffer from persisting sequelae after acute disease. This is referred to as Long COVID. The objective of this study was to assess factors associated with Long COVID and to analyze differences in persistent symptoms, findings on chest imaging and pulmonary function between intensive care unit (ICU) and non-ICU hospitalized patients. Methods We conducted a retrospective study including patients hospitalized with COVID-19. Patients were stratified into ICU patients and non-ICU patients. We analyzed the outcomes of patients who were in clinical follow-up six months after discharge with persistent symptoms, radiological and/or functional abnormalities.. Logistic regression was used to examine the association between Long COVID and patient characteristics. Results A total of 549 patients were included. Eighty-one ICU patients (66%) and 146 (34%) non-ICU patients had persistent symptoms or abnormalities on chest imaging or lung function test minimally six months after discharge. Significantly more ICU patients had residual fibrotic abnormalities on chest-CT and functional impairment. Female gender, myocardial infarction, OSAS, low PCO2 at admission and longer hospital stay were associated with a higher risk of developing Long COVID. Diabetes and treatment with tociluzimab were associated with a lower risk of developing Long COVID. Conclusion Of the patients hospitalized for COVID-19 34-66 percent suffered from persistent symptoms, residual abnormalities on chest imaging or reduced lung function at around six months after discharge. While persistent sequelae were more frequent in ICU patients, admission to the ICU was not found to be an independent risk factor for developing Long COVID.

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Carbon dioxide and MAPK signalling: towards therapy for inflammation

Gałgańska,

Jarmuszkiewicz,

Gałgański

2023

Cell Commun Signal

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Inflammation, although necessary to fight infections, becomes a threat when it exceeds the capability of the immune system to control it. In addition, inflammation is a cause and/or symptom of many different disorders, including metabolic, neurodegenerative, autoimmune and cardiovascular diseases. Comorbidities and advanced age are typical predictors of more severe cases of seasonal viral infection, with COVID-19 a clear example. The primary importance of mitogen-activated protein kinases (MAPKs) in the course of COVID-19 is evident in the mechanisms by which cells are infected with SARS-CoV-2; the cytokine storm that profoundly worsens a patient’s condition; the pathogenesis of diseases, such as diabetes, obesity, and hypertension, that contribute to a worsened prognosis; and post-COVID-19 complications, such as brain fog and thrombosis. An increasing number of reports have revealed that MAPKs are regulated by carbon dioxide (CO2); hence, we reviewed the literature to identify associations between CO2 and MAPKs and possible therapeutic benefits resulting from the elevation of CO2 levels. CO2 regulates key processes leading to and resulting from inflammation, and the therapeutic effects of CO2 (or bicarbonate, HCO3−) have been documented in all of the abovementioned comorbidities and complications of COVID-19 in which MAPKs play roles. The overlapping MAPK and CO2 signalling pathways in the contexts of allergy, apoptosis and cell survival, pulmonary oedema (alveolar fluid resorption), and mechanical ventilation–induced responses in lungs and related to mitochondria are also discussed.

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Correlation between venous blood gas indices and radiological involvements of COVID-19 patients at first admission to emergency department

Cited by 3 publications

References 18 publications

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

Predictors for Long COVID and Differences in Long COVID Symptoms, Findings on Chest Imaging and Pulmonary Function between Hospitalized COVID-19 Patients with versus without Intensive Care Unit Admission

Carbon dioxide and MAPK signalling: towards therapy for inflammation

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