Telomere length: biological marker of cellular vitality, aging, and health-disease process

Teixeira, Marcus Zulian

doi:10.1590/1806-9282.67.02.20200655

Cited by 8 publications

(4 citation statements)

References 77 publications

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“…Composite BoAs have the potential to exceed age and should be investigated more in the future. Considering the entanglement of telomere dysfunction in disease onset, cellular vitality or activity, aging or longevity, measuring the LTL provides a clinical parameter that can be useful for diagnosis and prognosis (8,(164)(165)(166), together with the evaluation of various therapies' efficiency, both conventional (167) and nonconventional (3). Because the level of telomere erosion is so important for the assessment of human health and course of the aging process, TL is by far the most researched biomarker of ARDs.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…This is due to the fact that aging is the leading cause of most pathological conditions that compromise healthspan and promote age-related diseases (ARDs), which constitute a constant and growing burden on healthcare systems around the world (2). The aging process is modulated by many genetic and non-genetic determinants, and it can be defined by chronological and biological age (3). Individuals of the same age show differences in many aspects of health status, implying that chronological age, i.e., the number of years that have passed since birth, does not reflect the functional individual status in the best way, which was the main reason for the development of the concept of biomarkers of aging (BoAs) (4).…”

Section: Introductionmentioning

confidence: 99%

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Telomere length as a biomarker of aging and diseases

Guzonjić¹,

Sopić²,

Ostanek³

et al. 2022

Arhiv za farmaciju

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As research related to healthspan and lifespan has become a hot topic, the necessity for a reliable and practical biomarker of aging (BoA), which can provide information about mortality and morbidity risk, along with remaining life expectancy, has increased. The chromosome terminus non-coding protective structure that prevents genomic instability is called a telomere. The continual shortening of telomeres, which affects their structure as well as function, is a hallmark of agedness. The aforementioned process is a potential cause of age-related diseases (ARDs), leading to a bad prognosis and a low survival rate, which compromise health and longevity. Hence, studies scrutinizing the BoAs often include telomere length (TL) as a prospective candidate. The results of these studies suggest that TL measurement can only provide an approximate appraisal of the aging rate, and its implementation into clinical practice and routine use as a BoA has many limitations and challenges. Nevertheless, measuring TL while determining other biomarkers can be used to assess biological age. This review focuses on the importance of telomeres in health, senescence, and diseases, as well as on summarizing the results and conclusions of previous studies evaluating TL as a potential BoA.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Telomere length as a biomarker of aging and diseases

Guzonjić¹,

Sopić²,

Ostanek³

et al. 2022

Arhiv za farmaciju

View full text Add to dashboard Cite

show abstract

“…Telomeres have been postulated as a universal biological clock that shorten in parallel with the division and aging of cells. The length of telomeres, particularly the abundance of short telomeres, has been proposed as a biomarker of senescence, aging, and general health status [1]. Telomeres are unique structures at the ends of eukaryotic chromosomes that protect them from degradation.…”

Section: Introductionmentioning

confidence: 99%

An Open-Label Clinical Trial Analyzing the Efficacy of a Novel Telomere-Protecting Antiaging Face Cream

et al. 2022

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Telomere length, a hallmark of cellular senescence, decreases with age and is associated with age-related diseases. Environmental factors, including dietary and lifestyle factors, can affect the rate at which telomeres shorten, and telomere protection prevents this from happening. The protection of telomeres by natural molecules has been proposed as an antiaging strategy that may play a role in treating age-related diseases. This study investigated the effect of a cycloartane-type triterpene glycoside (astragaloside IV). Astragaloside IV is one of the primary compounds from the aqueous extract of Astragalus membranaceus, and it provides telomere protection both in vitro and in vivo. In a study cohort with 13 participants, telomere length in human skin samples was analyzed after daily treatment for 4 weeks. A comparison of the average median telomere length between the treatment and control groups (5342 bp vs. 4616 bp p = 0.0168) showed significant results. In the second clinical cohort with 20 participants, skin parameters at baseline and after 4 and 8 weeks were measured in vivo. The results show that the product improved hydration by 95%, the skin appeared brighter by 90%, and wrinkle visibility was reduced by 70%. The combination of biologically active compounds in the cream possesses telomere-protecting properties and notable antioxidant activity in vitro and in vivo.

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“…And this may eventually lead to cellular senescence and apoptosis (3) . Therefore, telomere length can be used as a biomarker of cellular ageing and health-disease processes (4) .…”

mentioning

confidence: 99%

Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population

Zhao,

Jin,

Zhang

et al. 2023

Br J Nutr

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Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length in leukocytes (RTL). This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A generalized linear regression model (GLM) and a restricted cubic spline (RCS) model were used to assess the correlation of DAI and its components with RTL. Generalized linear regression analysis revealed that DAI (β = 0.005, P = 0.002) and the intake of its constituents vitamin C (β = 0.043, P = 0.027), vitamin E (β = 0.088, P < 0.001), selenium (β = 0.075, P = 0.003), and zinc (β = 0.075, P = 0.023) were significantly and positively correlated with RTL. Gender-stratified analysis showed that DAI (β = 0.006, P = 0.005) and its constituents vitamin E (β = 0.083, P = 0.012), selenium (β = 0.093, P = 0.006), and zinc (β = 0.092, P = 0.034) were significantly and positively correlated with RTL among females. Meanwhile, among males, only vitamin E intake (β = 0.089, P = 0.013) was significantly and positively associated with RTL. RCS analysis revealed linear positive associations between DAI and its constituents’ (vitamin E, selenium, and zinc) intake and RTL in the total population. Sex-stratified analysis revealed a linear positive correlation between DAI and its constituents’ (vitamin E, selenium, and zinc) intake and RTL in females. Our study found a significant positive correlation between DAI and RTL, with gender differences.

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Telomere length: biological marker of cellular vitality, aging, and health-disease process

Cited by 8 publications

References 77 publications

Telomere length as a biomarker of aging and diseases

Telomere length as a biomarker of aging and diseases

An Open-Label Clinical Trial Analyzing the Efficacy of a Novel Telomere-Protecting Antiaging Face Cream

Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population

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