Drug-induced nephrotoxicity

Sales, Gabriel Teixeira Montezuma; Foresto, Renato Demarchi

doi:10.1590/1806-9282.66.s1.82

Cited by 82 publications

(69 citation statements)

References 18 publications

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“…Drug-induced AKI accounts for up to 60% of all cases, resulting in a severe threat to hospitalized patients [4].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Traditional Herbal Formulas on Cisplatin-Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Dachuri

Song

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Acute kidney injury (AKI) is characterized by a rapid loss of renal function. Drug-induced AKI accounts for up to 60% of all cases, resulting in a severe threat particularly to hospitalized patients, but there are no effective treatments. Four polyherbal formulas, Bojungikki-tang (BJ), Palmijihwang-tang (PJ), Oryeong-san (OR), and Wiryeong-tang (WR), have long been used for treatments of symptoms of kidney disease in traditional Korean medicine. Even though they are commercially available, evidences supporting the efficacy on AKI are still lacking. Therefore, the effectiveness of polyherbs on AKI and the underlying mechanisms were examined. Renal cell damage was induced by cisplatin at 20 μM and 16 μM in proximal tubular epithelial cell lines of rat NRK-52E and human HK-2, respectively. The cells were treated with the polyherbal formals for 3 days, and the cell viability, antioxidant activities, and apoptosis were examined. In addition, the proliferative effects were assessed under serum-free conditions. The results were compared with those of the vehicle-treated cells as a control. Three polyherbs BJ, PJ, and WR but not OR showed strong free radical scavenging activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The treatments of BJ, PJ, OR, and WR significantly increased the cell viabilities under cisplatin-induced nephrotoxicity. Consistent with the results of the DPPH assay, superoxide dismutase and catalase activities were increased in the cisplatin-induced cell model treated with BJ, PJ, and WR but not with OR. However, annexin-V-positive cells and cleaved caspase 3 expression were significantly reduced in the cell model treated with all of the polyherbs. Cell proliferation was observed in treatment with all of the polyherbs, which was particularly evident in the OR-treated cells. This provides effective complementary evidences to promote the development of traditional herbal formulas to treat AKI.

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“…Drug-induced AKI accounts for up to 60% of all cases, resulting in a severe threat to hospitalized patients [4].…”

Section: Introductionmentioning

confidence: 99%

“…Drug-induced AKI accounts for up to 60% of all cases, resulting in a severe threat to hospitalized patients [ 4 ]. Cisplatin is one of the most efficient and widely used antineoplastic drugs; however, its application is restricted due to the side effects, including nephrotoxicity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Traditional Herbal Formulas on Cisplatin-Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Dachuri

Song

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…D-AKI was found to be associated with 46 drugs, and the incidence was calculated, significantly improving the efficacy in determining the ADR occurrence in a large sample population in a multidrug environment. Currently, AKI is still a common complication that is associated with a high mortality rate and prolonged hospital stay [ 26 , 27 ]. Accordingly, studying D-AKI to determine specific risk factors is of major importance.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study

Guo

Yan

et al. 2020

BioMed Research International

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Background. Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. Results. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alcohol abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). Conclusions. The occurrence of D-AKI in hospitalized patients had significant associations with alcohol abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics.

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“…Safety of psychotropic drugs is nowadays one of the most ambiguous research problems. Concerns regarding the possible detrimental effect of psychotropic medications on kidney function are supported by a recent meta-analysis [3], [4]. Recently, several independent researchers have reported that psychotropic remedies exhibit a cytotoxic effect in human cell cultures, increasing oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 20% of nephrotoxicity is induced by drugs [2], [3]. Medicinal lesions of the kidneys are one of the common causes of both acute and chronic nephropathy, endangering the patient's life.…”

Section: Introductionmentioning

confidence: 99%

Drug-induced Nephropathy and Molecular Patterns of Oxidative Stress

Lee¹,

Bakirova²,

Muravlyova³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Drug-induced kidney disorder is a frequent adverse event which contributes to morbidity and even incapacitation. Our current knowledge of drug-induced kidney disease is limited due to varying definitions of kidney injury, incomplete assessment of concurrent risk factors, and lack of long term outcome reporting. AIM: The discovery and development of novel biomarkers and local (renal) response mechanisms, which can diagnose kidney damage earlier and more accurately, are needed for effective prevention of drug-induced nephrotoxicity. METHODS: Forty patients from 22 to 50 years old with drug-induced nephropathy (43 females, 27 males) were included in the study. The determination of oxidative stress modifications as advanced oxidation protein products (AOPPs), protein reactive carbonyl derivatives (PRCD), methylglyoxal, and catalase (CAT) level were assayed. AOPP was rated in blood plasma through the Witko-Sarsat (1996) method, PRCD by Levine (2000) method, methylglyoxal through the Racker (1963) method, CAT was evaluated with Koroljuk (1988) and Aebi (1984) methods. Conditionally, 30 healthy-matched persons were included in the control group. RESULTS: In psychotropic and nonsteroidal anti-inflammatory drugs (NSAID) drug-induced nephropathy patients, there was a tendency to increase the concentration of AOPP in blood plasma, PRCD, and methylglyoxal in erythrocytes relative to the upper limits of normal ranges. Moreover, there was a significant decrease of the CAT level in blood plasma relative to the upper limits of normal ranges. CONCLUSION: Thus, the results of the present study permit us to draw the following conclusions. The patients with psychotropic and NSAIDs drug-induced nephropathy have increased level of oxidative stress products and increased neutrophil gelatinase-associated lipocalin level even in normal eGFR. The mechanisms that lead to the development of oxidative stress and the production of modified proteins are different in patients treated with different drugs.

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Drug-induced nephrotoxicity

Cited by 82 publications

References 18 publications

Protective Effects of Traditional Herbal Formulas on Cisplatin-Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Protective Effects of Traditional Herbal Formulas on Cisplatin-Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study

Drug-induced Nephropathy and Molecular Patterns of Oxidative Stress

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