An estimate of the incidence and prevalence of laryngeal papillomatosis in São Paulo State (Brasil)

Mercuri, Gustavo; Rodriguês, Sérgio Augusto; Martins, Regina Helena Garcia

doi:10.1590/1806-9282.66.9.1247

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The cohort studies reported in the literature had relatively small sample sizes of RRP patients. Ximenes Filho et al 20 conducted a ten-year retrospective cohort study with 44 patients, while Matos et al 23 have also evaluated 25 patients with RRP, and in a third study, Silva et al 36 performed a ten-year retrospective study with 21 patients. These three studies were carried out in Sao Paulo State.…”

Section: Discussionmentioning

confidence: 99%

Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population

Carvalho

Brito

Cunha

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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This study presents 25 cases of recurrent respiratory papillomatosis (RRP) that occurred in Sao Luis, Maranhao State, Northeast region, Brazil, between January 2007 and December 2018. Sociodemographic and clinical profile of patients as well as human papillomavirus (HPV) infection status were evaluated. Clinical and histopathological data were collected from the patients' medical records. For the HPV infection analysis, DNA was extracted and subjected to amplification by a nested polymerase chain reaction. Viral genotyping was performed by automated sequencing. The median age of patients was 12.40 ± 12.6. years, and the juvenile form of the disease (68%) was the predominant form of disease. Female participants were predominant (60%), and they were from cities located in the interior of the State (60%). The most common clinical manifestation was dysphonia; recurrence was observed in most cases (56%), and tracheostomy was necessary in seven patients (26.9%). When comparing the RRP forms, patients in the juvenile-RRP group had higher recurrence rates and need of tracheostomy than those in the adult-RRP group. The viral genotyping analysis revealed that 47.8% of patients had low-risk HPVs, whereas 13.1% had high-risk HPVs, and in 39.1% of patients the viral genotype was not obtained. HPV-6 was the most prevalent type and Juvenile-RRP was more prevalent in our population. HPV was present at a high rate, and HPV-6 was the predominant genotype. This study serves as the basis for further studies to be conducted in the Brazilian population. Our findings aid the better understanding of RRP, possibly suggesting some prognostic factors associated with the disease aggressiveness.

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Section: Discussionmentioning

confidence: 99%

Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population

Carvalho

Brito

Cunha

et al. 2021

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…Humano o VPH, ésta es la lesión benigna más frecuente causada por este virus, sobre todo por los tipos 6 y 11 hasta en 50 a 100% de casos, también pueden deberse a otros subtipos como el 16 y 18 de mayor riesgo oncológico (2,5).…”

Section: Es Causada Por Un Virus Adn De La Familia Papillomaviridae L...unclassified

“…La Papilomatosis Respiratoria Recurrente (PRR) se define como el crecimiento benigno recurrente de lesiones papilomatosas en el tracto aerodigestivo superior que puede comprometer la vocalización, la respiración y la deglución.1 No es una enfermedad muy frecuente pero aun así implica un gran impacto económico y en la calidad de vida de los pacientes, las estimaciones de la prevalencia e incidencia de la PRR son imprecisas, en nuestra región en el estudio del 2020 en los cinco mayores centros regionales de Salud del interior de São Paulo Brasil se encontró una incidencia y prevalencia de 1,87-11,46 y 6,86-22,92 por 1.000.000 de habitantes respectivamente (1,2).…”

Section: Introductionunclassified