Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome

Mansıroğlu, Aslı Kurtar; Sıncer, İsa; Güneş, Yılmaz

doi:10.1590/1806-9282.66.7.954

Cited by 6 publications

(4 citation statements)

References 24 publications

(7 reference statements)

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“… 22 Interestingly, an elevated NLR, reflecting the balance between the innate and the adaptive immune responses, has been associated not only with the presence of CVD but also with short-term adverse outcomes, including mortality, in patients with CVD. 23 In accordance with previous reports, 24 , 25 we found higher levels of neutrophils and NLR in STEMI patients at admission compared with patients with stable angina. However, herein we showed that there was a significant decrease in neutrophil counts and NLR, mainly driven by a reduction in neutrophil counts, during hospitalisation in the tocilizumab arm compared with placebo.…”

Section: Discussionsupporting

confidence: 92%

Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial

et al. 2022

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Section: Discussionsupporting

confidence: 92%

Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial

et al. 2022

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“…In agreement with our study, Mansiroglu et al (16) conducted a single-centered study of 426 patients who were admitted to Bolu Abant Izzet university hospital, to assess the relation between NLR and ACS. They realized that neutrophil and NLR were higher in NSTEMI patients that in unstable angina patients, also El Shafey et al (17) concord with our study that higher NLR counts for NSTEMI patients unlike lower NLR for unstable angina.…”

Section: Discussionsupporting

confidence: 87%

Role of Neutrophil to Lymphocyte Ratio as a Predictor in Risk Stratifying Patients With Nste-Acs

Abdul-Wahab,

El Abd,

El Hinnawy

et al. 2023

Ain Shams Medical Journal

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Background: Acute myocardial infarction is known to be accompanied by elevated leukocyte count. The differentiation of leukocyte types gives an added benefit of judging the severity of A.C.S. & predicting its clinical outcomes. Collecting peripheral blood samples is an easy & inexpensive test.Aim: To test the significance of Neutrophil to Lymphocyte ratio in risk stratifying patients with acute coronary syndromes and its early outcomes.Methods: One hundred patients with UA and NSTEMI were prospectively evaluated at Ain Shams University Hospital (63% UA and 37% NSTEMI). The patients were followed-up for clinical outcomes for 48 hours in-hospital & for one month after discharge. Results:The median (IQR) NLR was 8.4 (5.3 to 9.7) in NSTEMI group versus 1.8 (1.2 to 2.8) in unstable angina group, NLR > 3.9 had a sensitivity of 100%, & specificity of 92% as a diagnostic value. The patients were categorized into three groups: low risk, intermediate risk, & high risk, according to TIMI score. In unstable angina patients, the quartiles of NLR in "low risk", "intermediate risk" and "high risk" groups were 3 (2.0, 4.3), 3.4 (2.4, 5.1) and 5.5 (3.4, 9.65). In NSTEMI patients, the quartiles of NLR in "low risk", "intermediate risk", and "high risk" groups were 5. 1 (3.1, 8.1), 5.2 (3.0, 9.0) and 6.5 (3.9, 11.7). Meaning that there is positive correlation, as NLR values were found to be significantly elevated in high-risk groups. Conclusion: NLR on presentation, is a powerful & independent predictor of cardiovascular outcomes in patients with NSTE-ACS. It represents a good marker for stratifying patients with NSTE-ACS. It appears to have the chance of revitalization as a practical biomarkerwith high clinical predictability and prognostication. The easiness and swiftness of doing this test make it simple, cheap, and flawless early predictor for risk stratification in patients with NSTE-ACS.

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“…In this inflammatory process neutrophils play a central and enhance inflammatory process by many mechanisms like arachdonic acid pathway, by generating oxygen free radicals and with the help of hydrolytic enzymes 13,14 . Lymphocytes have the ability to suppress inflammation and decreased lymphocyte count is associated with poor cardiac outcome 15 Stress during myocardial infarction lead to lymphopenia because of catecholamine induced apoptosis and suppression of maturation of lymphocytes 16,17,18 . So white blood cell count, neutrophil count and neutrophil lymphocyte ratio are simple inexpensive, readily available measure that can be used to stratify high risk patients 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Total White blood count, absolute neutrophil count and neutrophil lymphocyte ratio and heart failure in patients with STEMI

Khan¹,

Akhter²,

Sarfraz³

et al. 2022

PJMHS

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Background: In Pakistan risk factors for coronary Artery disease are highly prevalent. The cause of 30-40% death in Pakistan is coronary artery disease. Inflammatory markers have a significant role in cardiovascular events: These markers are C - reactive protein, interlukin-6 and high erythrocyte sedimentation rate. Few parameters are proposed to pedicel the outcome in coronary artery disease that includes WBC count neutrophil count and neutrophil/lymphocyte ratio. Methodology: It was a prospective descriptive study conducted in the Cardiac unit, Ibn-e-Siena Hospital, Multan. Data of 159 patients who met the inclusion criteria was collected. Patient’s demographic details were noted. All patients having any of these, cardiogenic shock, pump failure (ejection ≤30%) and acute pulmonary edema were taken as having heart failure. Results: In this study main population was from age group 61-70 and 51-60 years age group. White blood count, absolute neutrophil count and neutrophil lymphocyte ratio was compared in patients with heart failure and without heart failure and significant difference was noted among groups. Conclusion: So white blood cell count, absolute neutrophil count and neutrophil lymphocyte ratio are good predictor of heart failure in patients with STEMI. So these parameters can be used to stratify high risk patients and can help in early identification and management of high risk patients Keywords: heart failure, neutrophil lymphocyte ratio, white cell count, ST segment elevation myocardial infarction.

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Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome

Cited by 6 publications

References 24 publications

Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial

Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial

Role of Neutrophil to Lymphocyte Ratio as a Predictor in Risk Stratifying Patients With Nste-Acs

Total White blood count, absolute neutrophil count and neutrophil lymphocyte ratio and heart failure in patients with STEMI

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