Hyperbilirubinemia impact on newborn hearing: a literature review

Teixeira, Marcela Hammes; Borges, Viviann Magalhães Silva; Riesgo, Rudimar dos Santos; Sleifer, Pricila

doi:10.1590/1806-9282.66.7.1002

Cited by 8 publications

(3 citation statements)

References 12 publications

(13 reference statements)

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“…However, one study reported no statistically significant difference between UB and TSB as predictors of hearing loss. 24 In a systematic review, Teixeira et al 25 reported a statistically significant correlation between audiological (ABR) changes and bilirubin levels, although TSB, UCB, or CB was used in the studies reviewed. According to that review, where no such correlation can be found, the reasons were differences in the bilirubin levels defined as critical to the start of treatment as well as the type of bilirubin used in the studies.…”

Section: Discussionmentioning

confidence: 99%

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Oyinwola

Mukhtar-Yola

Olusesi

et al. 2023

Journal of Neonatology

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Objective To determine the total serum bilirubin (TSB) cut-off value predictive of hearing impairment among newborns with hyperbilirubinemia at the National Hospital Abuja. Setting This was a cross-sectional study conducted in the Special Care Baby Unit (SCBU) and Neonatal Intensive Care Unit (NICU) of National Hospital Abuja between August 2020 and February 2021. Methods A universal sampling of eligible participants was done, and consent was obtained from the parent. Using the TSB and results of hearing screening carried out with the Otoport advance from Otodynamics®, the proportion of automated auditory brainstem response (AABR) screening failure was determined, and the receiver’s operating characteristics (ROC) curve coordinates were used to find the threshold bilirubin level for the risk of hearing loss. The Spearman-Rho correlation assessed the relationship between TSB level and AABR findings. Results 160 newborns below 28 days of age, delivered at 34 weeks gestation and above, who had clinical jaundice were recruited. The prevalence of screening AABR failure in at least one ear was 26.2%. The correlation between TSB and AABR was weakly positive (rs = .189, p = .093) and the TSB cut-off for AABR failure was 16.3 mg/dl (sensitivity 45.5%, specificity 81%, Youden’s-J statistic = 0.265). Conclusion The TSB threshold for AABR screening failure was 16.3 mg/dl, but TSB did not correlate well with screening AABR. Serum bilirubin above 15 mg/dl in late preterm and term neonates should be actively treated with phototherapy and/or exchange blood transfusions where feasible, particularly in resource-poor settings.

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Section: Discussionmentioning

confidence: 99%

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Oyinwola

Mukhtar-Yola

Olusesi

et al. 2023

Journal of Neonatology

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“…The pathophysiology of hyperbilirubinemia includes an auditory pathway problem with normal peripheral function of the ear such as non-affected hair cells ( Belal, 1975 ; Shaia, Shapiro, & Spencer, 2005 ). Studies have showed increase in ABR (Auditory Brainstem Response) latencies and interpeak intervals in hyperbilirubinemia animal models ( Shapiro & Hecox, 1989 ; Teixeira, Borges, Riesgo, & Sleifer, 2020 ). This phenomenon can be explained by the degenerative appearance of the spiral ganglion, where the neurons demonstrate decreased size and a lack of myelinated axons ( Shaia et al, 2005 ).…”

Section: Environmental Causes Of Congenital Hearing Lossmentioning

confidence: 99%

Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

Renauld

Basch

2021

Current Protocols

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Congenital hearing loss is the most common birth defect, estimated to affect 2‐3 in every 1000 births. Currently there is no cure for hearing loss. Treatment options are limited to hearing aids for mild and moderate cases, and cochlear implants for severe and profound hearing loss. Here we provide a literature overview of the environmental and genetic causes of congenital hearing loss, common animal models and methods used for hearing research, as well as recent advances towards developing therapies to treat congenital deafness. © 2021 The Authors.

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“…Auditory brainstem response is also a well-known way of diagnosing ABE, but the relationship of serum bilirubin levels and auditory alterations is still not well defined. Thus the thresholds of blood bilirubin considered critical to the auditory impairment are not determined (11).…”

Section: Introductionmentioning

confidence: 99%

Amplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy

Chang¹,

Zheng²,

Ju³

et al. 2021

Transl Pediatr

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Background: To establish a clinical prediction model of acute bilirubin encephalopathy (ABE) using amplitude-integrated electroencephalography (aEEG). Methods: A total of 114 neonatal hyperbilirubinemia patients in the Beijing Chaoyang hospital from August 2015 to October 2018 were enrolled in this study. There were 62 (54.38%) males, and the age of patients undergoing aEEG examination was 2-23 days, with an average of 7.61±4.08 days. Participant clinical information, peak bilirubin value, albumin value, hyperbilirubinemia, and the graphic indicators of aEEG were extracted from medical records, and ABE was diagnosed according to a bilirubin-induced neurological dysfunction (BIND) score >0. Multivariable logistic regression was used to establish a clinical prediction model of ABE. Furthermore, decision curve analysis (DCA) was performed to evaluate the model's predictive value. Results: According to the BIND score, there were a total of 23 (20.18%) ABE cases. The multivariable logistic regression analysis showed that the value of bilirubin/albumin (B/A), presence of hyperbilirubinemia risk factors, number of sleep-wake cycling (SWC) within 3 hours, widest bandwidth, duration of SWC, and type of SWC were significantly associated with ABE. A clinical prediction model was developed as: p=ex/ (1+ex), X=0.278+0.713*B/A+2.602*with risk factors (with risk factors equals 1) − 1.500*SWC number within 3 hours + 0.219*the widest bandwidth-0.065*the duration of one SWC + 1.491* SWC (mature SWC equals 0, immature SWC equals 1). The area under the curve (AUC) was 0.85 [95% confidence interval (CI): 0.75-0.94], which was significantly higher than the AUC only based on conventional clinical information of B/A (AUC: 0.58, 95% CI: 0.45-0.72). The DCA also showed good predictive ability compared to B/A. Conclusions: A clinical prediction model can be established based on the patients' B/A, presence of risk factors for hyperbilirubinemia, number of SWC within 3 hours, widest bandwidth, duration of 1 SWC, and the type of SWC. It has good predictive ability and may improve the diagnostic accuracy of ABE.

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Hyperbilirubinemia impact on newborn hearing: a literature review

Cited by 8 publications

References 12 publications

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

Amplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy

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